3-hydroxy-2-pentyl-1H-quinolin-4-one | 521313-34-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-hydroxy-2-pentyl-1H-quinolin-4-one
• CAS: 521313-34-8；1160739-56-9
• 化学式: C₁₄H₁₇NO₂
• 分子量: 231.294
• InChiKey: KUTYGAXEBKVQDY-UHFFFAOYSA-N

物化性质

• 沸点：
  394.0±37.0 °C(Predicted)
• 密度：
  1.180±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-氯-2-庚酮 、 邻氨基苯甲酸 在 N,N-二异丙基乙胺 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 0.5h， 生成 3-hydroxy-2-pentyl-1H-quinolin-4-one
  参考文献：
  名称：

  Microwave and flow syntheses of Pseudomonasquinolone signal (PQS) and analogues

  摘要：

  报告采用微波和流动方法对假单胞菌喹啉信号（PQS）及其相关结构类似物进行的便捷合成。

  DOI：

  10.1039/c0ob00652a

文献信息

• Methods for inducing autolysis in infectious bacteria
  申请人：Haptogen Ltd

  公开号：EP2261260A2

  公开（公告）日：2010-12-15

  The present invention relates to methods for the killing of infectious bacteria by modulating the extra-cellular concentration of bacterial cell signalling molecules. This has the effect of inducing rapid cell death (autolysis) in the majority of bacterial cells, and preventing virulence or restoring a benign state in surviving cells. These receptors have applications for the treatment of individuals with susceptibility to infection, the treatment of patients with existing infections, in disease management, and in related applications where the host for infection is an animal or plant. The compositions described herein are particularly relevant to Pseudomonas aeruginosa infection, for example in the treatment of pulmonary infection in cystic fibrosis patients, and represent a unique bactericidal medication that does not directly target the bacteria.

  本发明涉及通过调节细菌细胞信号分子的细胞外浓度来杀死传染性细菌的方法。其效果是诱导大多数细菌细胞快速死亡（自溶），防止毒力增强或使存活细胞恢复良性状态。这些受体可用于治疗易受感染的个体、治疗已有感染的病人、疾病管理以及感染宿主为动物或植物的相关应用。本文所述组合物尤其适用于铜绿假单胞菌感染，例如用于治疗囊性纤维化患者的肺部感染，是一种不直接针对细菌的独特杀菌药物。
• METHODS FOR INDUCING AUTOLYSIS IN INFECTIOUS BACTERIA
  申请人：Haptogen Ltd

  公开号：EP1730197A2

  公开（公告）日：2006-12-13
• Methods For Inducing Autolysis In Infectious Bacteria
  申请人：Charlton Alan Keith

  公开号：US20070218058A1

  公开（公告）日：2007-09-20

  The present invention relates to methods for the killing of infectious bacteria by modulating the extra-cellular concentration of bacterial cell signalling molecules. This has the effect of inducing rapid cell death (autolysis) in the majority of bacter cells, and preventing virulence or restoring a benign state in surviving cells. These receptors have applications for the treatment of individuals with susceptibility to infection, the treatment of patients with existing infections, in disease management, and in related applications where the host for infection is an animal or plant. The compositions described herein are particularly relevant to Pseudomonas aeruginosa infection, for example in the treatment of pulmonary infection in cystic fibrosis patients, and represent a unique bactericidal medication that does not directly target the bacteria.
• [EN] METHODS FOR INDUCING AUTOLYSIS IN INFECTIOUS BACTERIA<br/>[FR] METHODES POUR INDUIRE UNE AUTOLYSE DANS DES BACTERIES INFECTIEUSES
  申请人：HAPTOGEN LTD

  公开号：WO2005094883A2

  公开（公告）日：2005-10-13

  The present invention relates to methods for the killing of infectious bacteria by modulating the extra-cellular concentration of bacterial cell signalling molecules. This has the effect of inducing rapid cell death (autolysis) in the majority of bacterial cells, and preventing virulence or restoring a benign state in surviving cells. These receptors have applications for the treatment of individuals with susceptibility to infection, the treatment of patients with existing infections, in disease management, and in related applications where the host for infection is an animal or plant. The compositions described herein are particularly relevant to Pseudomonas aeruginosa infection, for example in the treatment of pulmonary infection in cystic fibrosis patients, and represent a unique bactericidal medication that does not directly target the bacteria.
• Microwave and flow syntheses of Pseudomonasquinolone signal (PQS) and analogues
  作者：James T. Hodgkinson、Warren R. J. D. Galloway、Shreya Saraf、Ian R. Baxendale、Steven V. Ley、Mark Ladlow、Martin Welch、David R. Spring

  DOI：10.1039/c0ob00652a

  日期：——

  Expedient syntheses of Pseudomonas quinolone signal (PQS) and related structural analogues using microwave and flow methods are reported.

  报告采用微波和流动方法对假单胞菌喹啉信号（PQS）及其相关结构类似物进行的便捷合成。