1-[4-bromo-2-(2-triethoxysilyl)ethylphenyl]ethanone | 1233131-19-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[4-bromo-2-(2-triethoxysilyl)ethylphenyl]ethanone
• 英文别名: 1-[4-Bromo-2-(2-triethoxysilylethyl)phenyl]ethanone
• CAS: 1233131-19-5
• 化学式: C₁₆H₂₅BrO₄Si
• 分子量: 389.362
• InChiKey: HZERNARMAJDSNU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.24
• 重原子数：
  22
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  乙烯基三乙氧基硅烷 、 4-溴苯乙酮 在 rhodium(III) chloride hydrate 、 sodium formate 、 三(4-三氟甲苯基)膦 作用下， 以 1,4-二氧六环 为溶剂， 反应 20.0h， 以207 mg的产率得到1-[4-bromo-2-(2-triethoxysilyl)ethylphenyl]ethanone
  参考文献：
  名称：

  Ruthenium Chloride as an Efficient Catalytic Precursor for Hydroarylation Reactions via C−H bond Activation

  摘要：

  A very simple and efficient catalytic system for the hydroarylation of olefins by aromatic ketones and Michael acceptors using simple and inexpensive ruthenium trichloride as a ruthenium source is described. These very mild conditions (dioxane at 80 C) appeared to be highly compatible, tolerant, and selective toward various functional groups, and the ease of the protocol is highly convenient for synthetic purposes.

  DOI：

  10.1021/ol101038c

文献信息

• Ruthenium Chloride as an Efficient Catalytic Precursor for Hydroarylation Reactions via C−H bond Activation
  作者：Marc-Olivier Simon、Jean-Pierre Genet、Sylvain Darses

  DOI：10.1021/ol101038c

  日期：2010.7.2

  A very simple and efficient catalytic system for the hydroarylation of olefins by aromatic ketones and Michael acceptors using simple and inexpensive ruthenium trichloride as a ruthenium source is described. These very mild conditions (dioxane at 80 C) appeared to be highly compatible, tolerant, and selective toward various functional groups, and the ease of the protocol is highly convenient for synthetic purposes.