-L-valyl>-L-proline | 95500-87-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: -L-valyl>-L-proline
• 英文别名: N-alpha-N-epsilon-Bis-benzyloxycarbonyl-L-lysyl-L-valyl-L-proline；Cbz-Lys(Cbz)(Cbz)-Val-Pro-OH；(2S)-1-[(2S)-2-[[(2S)-2,6-bis(phenylmethoxycarbonylamino)hexanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carboxylic acid
• CAS: 95500-87-1
• 化学式: C₃₂H₄₂N₄O₈
• 分子量: 610.707
• InChiKey: SWDFQSFRAWWSLC-QKDODKLFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  44
• 可旋转键数：
  17
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  163
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  -L-valyl>-L-proline 在 N-甲基吗啉 、 sodium methylate 、 氯甲酸异丁酯 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 16.0h， 生成 2--L-valyl>-L-prolylamido-2-deoxy-β-D-glucose
  参考文献：
  名称：

  Synthesis and properties of d-glucosamine N-peptidyl derivatives as substrate analog inhibitors of papain and cathepsin B

  摘要：

  N-peptidyl derivatives of D-glucosamine 7c-7n were synthesized and tested as 7c-7n were synthesized and tested as reversible, substrate analog inhibitors of cysteine and serine-proteases. D-Glucosamine itself showed fair inhibiting properties against cysteine-proteases. Derivatives 7c-7i, designed to improve binding at papain active site, displayed reversible inhibition with K(i) ranging from 67-860-mu-M for papain and from 111-2400-mu-M for cathepsin B. Representative serine proteases were unaffected. No inhibitory activity against human leukocyte elastase was observed for derivatives 7m and 7n bearing very effective peptidyl recognizing units for this enzyme.

  DOI：

  10.1016/0223-5234(91)90001-4

文献信息

• Proline derivatives
  申请人：ICI AMERICAS INC.

  公开号：EP0124317A2

  公开（公告）日：1984-11-07

  Proline derivatives of the formulae: wherein R1 through R11 have defined values, and acid- and base-addition salts thereof, and equilibrium addition compounds of the aldehyde group thereof; processes for their preparation; pharmaceutical compositions; and intermediates for preparing said proline derivatives. The proline derivatives are human leukocyte elastase inhibitors which are useful, for example, in treating pulmonary emphysema.

  式中的脯氨酸衍生物： 式中 R1 至 R11 具有定义值的脯氨酸衍生物、其酸加成盐和碱加成盐、其醛基的平衡加成化合物；其制备工艺；药物组合物；以及制备上述脯氨酸衍生物的中间体。脯氨酸衍生物是人类白细胞弹性蛋白酶抑制剂，可用于治疗肺气肿等疾病。
• US4596789A
  申请人：——

  公开号：US4596789A

  公开（公告）日：1986-06-24
• US4691007A
  申请人：——

  公开号：US4691007A

  公开（公告）日：1987-09-01
• Synthesis and properties of d-glucosamine N-peptidyl derivatives as substrate analog inhibitors of papain and cathepsin B
  作者：C Giordano、C Gallina、V Consalvi、R Scandurra

  DOI：10.1016/0223-5234(91)90001-4

  日期：1991.11

  N-peptidyl derivatives of D-glucosamine 7c-7n were synthesized and tested as 7c-7n were synthesized and tested as reversible, substrate analog inhibitors of cysteine and serine-proteases. D-Glucosamine itself showed fair inhibiting properties against cysteine-proteases. Derivatives 7c-7i, designed to improve binding at papain active site, displayed reversible inhibition with K(i) ranging from 67-860-mu-M for papain and from 111-2400-mu-M for cathepsin B. Representative serine proteases were unaffected. No inhibitory activity against human leukocyte elastase was observed for derivatives 7m and 7n bearing very effective peptidyl recognizing units for this enzyme.