7-Quinolinol, 4-[[4-[ethyl(2-hydroxyethyl)amino]-1-methylbutyl]amino]- | 319913-01-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-Quinolinol, 4-[[4-[ethyl(2-hydroxyethyl)amino]-1-methylbutyl]amino]-
• 英文别名: 4-[5-[ethyl(2-hydroxyethyl)amino]pentan-2-ylamino]quinolin-7-ol
• CAS: 319913-01-4
• 化学式: C₁₈H₂₇N₃O₂
• 分子量: 317.4
• InChiKey: GHANPUNFPRITEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  68.6
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF<br/>[FR] COMPOSITIONS D'ACIDE NUCLÉIQUE-POLYPEPTIDE ET UTILISATIONS DE CELLES-CI
  申请人：AVIDITY BIOSCIENCES INC

  公开号：WO2020247782A1

  公开（公告）日：2020-12-10

  Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a modified polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.

  本文披露了包括与修饰的多核苷酸分子和聚合物结合的结合基团的组合物和药物配方。本文还描述了利用包括结合基团与多核苷酸分子和聚合物结合的组合物或药物配方治疗癌症的方法。
• [EN] UNA AMIDITES AND USES THEREOF<br/>[FR] AMIDITES D'UNA ET LEURS UTILISATIONS
  申请人：AVIDITY BIOSCIENCES INC

  公开号：WO2020247818A1

  公开（公告）日：2020-12-10

  Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a modified polynucleic acid molecule and a polymer. Also described herein include methods for treating a disease which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.

  本文披露了包含结合基团与修饰的多核苷酸分子和聚合物结合的组合物和药物配方。本文还描述了利用包含结合基团与多核苷酸分子和聚合物结合的组合物或药物配方进行治疗疾病的方法。
• Optimized in vivo delivery system with endosomolytic agents for nucleic acid conjugates
  申请人：ONXEO

  公开号：US10363317B2

  公开（公告）日：2019-07-30

  The present invention relates to an optimized in vivo delivery system with endosomolytic agents for nucleic acid of therapeutic interest conjugated to molecules facilitating endocytosis, in particular for use in the treatment of cancer.

  本发明涉及一种优化的体内递送系统，该系统含有内溶解剂，用于将具有治疗意义的核酸与促进内吞作用的分子连接在一起，特别是用于治疗癌症。
• Nucleic acid-polypeptide compositions and uses thereof
  申请人：Avidity Biosciences, Inc.

  公开号：US10550188B2

  公开（公告）日：2020-02-04

  Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.

  本文公开了包含与多核酸分子和聚合物共轭的结合分子的组合物和药物制剂。本文还描述了利用组合物或药物制剂治疗癌症的方法，组合物或药物制剂包含与多核酸分子和聚合物共轭的结合分子。
• Compositions and methods of treating muscle atrophy and myotonic dystrophy
  申请人：AVIDITY BIOSCIENCES, INC.

  公开号：US10881743B2

  公开（公告）日：2021-01-05

  Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle atrophy or myotonic dystrophy.

  本文公开了用于治疗肌肉萎缩或肌营养不良症的多核苷酸分子、药物组合物和方法。