ethoxy-hydroxy-phosphanyloxyl | 48014-95-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ethoxy-hydroxy-phosphanyloxyl
• 英文别名: ethyl H-phosphonate；phosphonic acid monoethyl ester; deprotonated form；phosphorous acid monoethyl ester; deprotonated form
• CAS: 48014-95-5
• 化学式: C₂H₆O₃P
• 分子量: 109.042
• InChiKey: VUERQRKTYBIULR-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.23
• 重原子数：
  6.0
• 可旋转键数：
  2.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.36
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  三甲基氯硅烷 、 ethoxy-hydroxy-phosphanyloxyl 在 三乙胺 作用下， 以 吡啶 为溶剂， 生成 ethyl bis(trimethylsilyl) phosphite
  参考文献：
  名称：

  Nucleoside H-Phosphonates. 18. Synthesis of Unprotected Nucleoside 5‘-H-Phosphonates and Nucleoside 5‘-H-Phosphonothioates and Their Conversion into the 5‘-Phosphorothioate and 5‘-Phosphorodithioate Monoesters

  摘要：

  A simple and efficient protocol for the preparation of unprotected nucleoside 5'-H-phosphonates and nucleoside 5'-H-phosphonothioates via a one-step deprotection of suitable precursors with methylamine has been developed. The synthetic utility of the unprotected nucleotide derivatives was demonstrated by converting them under mild conditions to the corresponding nucleoside 5'-phosphorothioate and nucleoside 5'-phosphorodithioate monoesters. Factors affecting oxidation of H-phosphonate, H-phosphonothioate, and phosphite derivatives with elemental sulfur are also discussed.

  DOI：

  10.1021/jo980491u
• 作为产物：
  描述：

  2-cyanoethyl ethyl phosphonate 在 正丁胺 作用下， 生成 ethoxy-hydroxy-phosphanyloxyl
  参考文献：
  名称：

  核苷H-膦酸酯与双功能试剂的反应研究。第三部分 核苷H-膦酸酯二酯与氨基醇酯交换的进一步研究

  摘要：

  摘要描述了5'-O-（4,4'-二甲氧基三苯甲基）胸苷-3'-基2-氰基乙基膦酸酯与吡啶中的醇，胺和氨基醇的反应：酯交换反应比2-的β-消除反应更快氰乙基

  DOI：

  10.1080/15257779508012484

文献信息

• Process for the preparation of 1-aminomethyl-1-cyclohexaneacetic acid
  申请人：Godecke Aktiengesellschaft

  公开号：US05091567A1

  公开（公告）日：1992-02-25

  The instant invention concerns a novel process for the preparation of 1-aminomethyl-1-cyclohexaneacetic acid (gabapentin), a known compound useful for treating certain cerebral diseases such as epilepsy and dizziness.

  本发明涉及一种新的制备1-氨甲基-1-环己基乙酸（加巴喷丁）的方法，该化合物已知可用于治疗某些脑部疾病，如癫痫和头晕。
• Phosphonate Compounds for Treatment of Complement Mediated Disorders
  申请人：Achillion Pharmaceuticals, Inc.

  公开号：US20150239921A1

  公开（公告）日：2015-08-27

  Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R 12 or R 13 on the A group is a phosphonate (R 32 ) are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor D's ability to modulate the classical and lectin complement pathways. The inhibitors of factor D described herein are capable of reducing the excessive activation of complement, which has been linked to certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer.

  提供了包括式子I或其药学上可接受的盐或组合物的补体因子D抑制剂的化合物、使用方法和制备方法，其中在A基团上的R12或R13是磷酸酯（R32）。本文所述的抑制剂靶向因子D，在替代性补体途径的早期和关键点抑制或调节补体级联反应，并减少因子D调节经典和凝集素补体途径的能力。本文所述的因子D抑制剂能够减少过度激活补体，这与某些自身免疫性、炎症性和神经退行性疾病，以及缺血再灌注损伤和癌症有关。
• Stawinski, Jacek; Thelin, Mats, Journal of the Chemical Society. Perkin transactions II, 1990, # 6, p. 849 - 853
  作者：Stawinski, Jacek、Thelin, Mats

  DOI：——

  日期：——
• Nucleoside <i>H</i>-Phosphonates. 18. Synthesis of Unprotected Nucleoside 5‘-<i>H</i>-Phosphonates and Nucleoside 5‘-<i>H</i>-Phosphonothioates and Their Conversion into the 5‘-Phosphorothioate and 5‘-Phosphorodithioate Monoesters
  作者：Jadwiga Jankowska、Anna Sobkowska、Jacek Cieślak、Michał Sobkowski、Adam Kraszewski、Jacek Stawiński、David Shugar

  DOI：10.1021/jo980491u

  日期：1998.11.1

  A simple and efficient protocol for the preparation of unprotected nucleoside 5'-H-phosphonates and nucleoside 5'-H-phosphonothioates via a one-step deprotection of suitable precursors with methylamine has been developed. The synthetic utility of the unprotected nucleotide derivatives was demonstrated by converting them under mild conditions to the corresponding nucleoside 5'-phosphorothioate and nucleoside 5'-phosphorodithioate monoesters. Factors affecting oxidation of H-phosphonate, H-phosphonothioate, and phosphite derivatives with elemental sulfur are also discussed.
• Studies on Reactions of Nucleoside H-Phosphonates with Bifunctional Reagents. Part III. Further Studies on Transesterification of Nucleoside H-Phosphonate Diesters with Amino Alcohols
  作者：Michal Sobkowski、Jacek Stawinki、Anna Sobkowska、Adam Kraszewski

  DOI：10.1080/15257779508012484

  日期：1995.5.1

  Abstract Reactions of 5′-O-(4,4′-dimethoxytrityl)thymidin-3′-yl 2-cyanoethyl phosphonate with alcohols, amines and amino alcohols in pyridine are described Transesterification was found to be faster than β-elimination of 2-cyanoethyl group

  摘要描述了5'-O-（4,4'-二甲氧基三苯甲基）胸苷-3'-基2-氰基乙基膦酸酯与吡啶中的醇，胺和氨基醇的反应：酯交换反应比2-的β-消除反应更快氰乙基