2,2,3,3,5,5-Hexamethylhexan-4-on | 5340-46-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2,3,3,5,5-Hexamethylhexan-4-on
• 英文别名: tert.-Butyl-triptyl-keton；2,2,4,4,5,5-hexamethyl-hexan-3-one；2,2,4,4,5,5-Hexamethyl-hexan-3-on；2,2,4,4,5,5-Hexamethylhexan-3-one
• CAS: 5340-46-5
• 化学式: C₁₂H₂₄O
• 分子量: 184.322
• InChiKey: KOFIQPLLXPZPBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,2,3,3,5,5-Hexamethylhexan-4-on 在 硫酸 、 溶剂黄146 作用下， 以 乙醚 为溶剂， 生成 2-tert-butyl-3,3,4,4-tetramethyl-pent-1-ene
  参考文献：
  名称：

  Thermal decomposition and dehydration of tri-tert-butylcarbinol. Competing free radical and carbonium ion reactions

  摘要：

  DOI：

  10.1021/jo00925a046
• 作为产物：
  描述：

  異丙基三級丁基酮 在 四氯化钛 、 potassium hydride 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 生成 2,2,3,3,5,5-Hexamethylhexan-4-on
  参考文献：
  名称：

  Lion, Claude; Dubois, Jacques-Emile, Bulletin de la Societe Chimique de France, 1982, vol. 2, # 11-12, p. 375 - 379

  摘要：

  DOI：

文献信息

• CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION
  申请人：Fresenius Kabi Deutschland GmbH

  公开号：US20150297738A1

  公开（公告）日：2015-10-22

  The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS′(-L-M) n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS′ is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.

  本发明涉及一种羟烷基淀粉共轭物及其制备方法，所述羟烷基淀粉共轭物包括羟烷基淀粉衍生物和细胞毒性药剂，所述细胞毒性药剂包括至少一个次级羟基，其中羟烷基淀粉通过所述次级羟基与细胞毒性药剂连接。根据本发明的共轭物具有以下公式HAS'(-L-M)n的结构，其中M是细胞毒性药剂的残基，L是连接基团，HAS'是羟烷基淀粉衍生物的残基，n大于或等于1，且羟烷基淀粉衍生物的平均分子量（MW）高于肾脏阈值。
• KINASE INHIBITORS
  申请人：MALTAIS FRANCOIS

  公开号：US20090124602A1

  公开（公告）日：2009-05-14

  The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

  本发明涉及用作蛋白激酶抑制剂的化合物。该发明还提供了含有所述化合物的药学上可接受的组合物以及使用这些组合物治疗各种疾病、状况或障碍的方法。该发明还提供了制备本发明化合物的方法。
• TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
  申请人：Babu Srinivasan

  公开号：US20110201593A1

  公开（公告）日：2011-08-18

  The invention provides novel compounds of formula I having the general formula: wherein R 1 , R 2 , R 3 , X and Y are as described herein. Accordingly, the compounds may be provided in pharmaceutically acceptable compositions and used for the treatment of immunological or hyperproliferative disorders.

  本发明提供了具有以下一般式的新化合物I： 其中R1、R2、R3、X和Y如本文所述。因此，这些化合物可以在药学上可接受的组合物中提供，并用于治疗免疫或过度增生性疾病。
• An Indolinone Derivative As Tyrosine Kinase Inhibitor
  申请人：KBP BIOSCIENCES CO., LTD.

  公开号：US20150306095A1

  公开（公告）日：2015-10-29

  The present invention relates to a compound represented by general formula (I), a method for preparing said compound, a pharmaceutical formulation containing said compound, and the use of said compound in manufacture of a medicament for treating or preventing the fibrous degeneration disease and treating the excessive proliferation disease: wherein ring A, X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , a, b and n are defined as those in the description.

  本发明涉及一种由通式(I)表示的化合物，制备该化合物的方法，含有该化合物的制药配方以及将该化合物用于制造治疗或预防纤维变性疾病和治疗过度增殖疾病的药物中的用途。其中，环A、X、R1、R2、R3、R4、R5、R6、R7、R8、R9、a、b和n的定义如描述中所述。
• Highly Branched Molecules. IV.¹ Solvolysis of the p-Nitrobenzoate of Tri-t-butylcarbinol and Some of its Homologs
  作者：Paul D. Bartlett、Martin Stiles

  DOI：10.1021/ja01615a041

  日期：1955.5