(1R,2R)-1,2-cyclopentanediyldimethanol | 75658-83-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1R,2R)-1,2-cyclopentanediyldimethanol
• 英文别名: [2-(hydroxymethyl)cyclopentyl]methanol
• CAS: 75658-83-2；35583-24-5
• 化学式: C₇H₁₄O₂
• 分子量: 130.187
• InChiKey: NXKFMUFJMLNJOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (1R,2R)-1,2-cyclopentanediyldimethanol 在 盐酸 、 盐酸肼 作用下， 以 水 为溶剂， 140.0 ℃ 、567.46 kPa 条件下， 反应 5.0h， 生成 N-氨基-3-氮杂双环[3.3.0]辛烷盐酸盐
  参考文献：
  名称：

  N-氨基-3-氮杂双环[3，3，0]辛烷盐酸盐的制备方法

  摘要：

  本发明涉及一种新的N‑氨基‑3‑氮杂双环[3，3，0]辛烷盐酸盐的制备方法。它需要解决的技术问题是，使制备方法工艺简化，污染减少以及避免使用致癌性物质。本发明制备方法，1)以式(II)物质为原料，加水，与卤酸肼在80～200℃温度下充分反应得反应液；2)反应结束后，浓缩反应液，加入水溶性醇使其溶解，并使过量的卤酸肼析出；3)滤去沉淀；处理母液，得到N‑氨基‑3‑氮杂双环[3，3，0]辛烷盐酸盐。

  公开号：

  CN108530340A
• 作为产物：
  描述：

  trans-DL-cyclopentane-1 ,2-dicarboxylic acid 在 三氟化硼乙醚 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 生成 (1R,2R)-1,2-cyclopentanediyldimethanol
  参考文献：
  名称：

  WO2007/30761

  摘要：

  公开号：

文献信息

• Photoresist monomers and preparation thereof
  申请人：Hyundai Electronics Industries Co., Ltd.

  公开号：US06359153B1

  公开（公告）日：2002-03-19

  The present invention relates to monomers for preparing photoresist polymer resins which can be used in a photolithography process employing a deep ultraviolet light source, and the preparation of the same. Preferred monomers are represented by following Chemical Formula 1: wherein, X represents CH2, CH2CH2, or oxygen; R1 represents hydrogen, C1-C5 alkyl, or R′OH; R2 represents hydrogen; —OH, C1-C5 alkoxy, or —OR′—OH; R′ represents:  and, m is an integer from 1-5, n is 1 or 2 and p is 0 or 1.

  本发明涉及用于制备可用于采用深紫外光源的光刻工艺中的光刻聚合物树脂的单体，以及其制备方法。优选单体由以下化学式1表示： <化学式1> 其中，X代表CH2、CH2CH2或氧； R1代表氢、C1-C5烷基或R′OH； R2代表氢、—OH、C1-C5烷氧基或—OR′—OH； R′代表：  并且， m为1-5的整数，n为1或2，p为0或1。
• [EN] PHOSPHONATE NUCLEOSIDES USEFUL IN THE TREATMENT OF VIRAL DISEASES<br/>[FR] NUCLÉOSIDES PHOSPHONATES UTILES DANS LE TRAITEMENT DE MALADIES VIRALES
  申请人：UNIV CORK

  公开号：WO2015177351A1

  公开（公告）日：2015-11-26

  The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or prodrug thereof, and their use in medicine particular as anti-viral agents; wherein: Base is a natural or non-natural nucleobase, and the other substituents are as defined in the claims.

  本发明涉及一种式(I)的化合物，或其在药学上可接受的盐或前药，以及它们在医学上特别作为抗病毒剂的用途；其中：基团是天然或非天然的核碱基，其他取代基如权利要求中所定义。
• Method for the production of n-alkenyl amides
  申请人：——

  公开号：US20030036659A1

  公开（公告）日：2003-02-20

  A process for preparing N-alkenyl-amides by reacting the corresponding NH-amides with acetylenes in the liquid phase in the presence of basic alkali metal compounds and of a cocatalyst comprises using as the cocatalyst diols of the general formula (I) 1 where X is branched or unbranched alkylene selected from the group consisting of 2 where R 1 to R 6 are independently hydrogen or C 1 - to C 4 -alkyl; or branched or unbranched cyclic alkylene of 3 to 14 carbon atoms including 3 to 12 ring carbon atoms, their monoalkenyl ethers, their dialkenyl ethers or mixtures thereof.

  一种制备N-烯基酰胺的方法，包括在液相中在碱性金属化合物和辅催化剂的存在下，将相应的NH-酰胺与乙炔反应，其中所述辅催化剂为通式（I）1的二醇，其中X是从2中选择的支链或直链烷基，所述2选自以下组：其中R1至R6独立地为氢或C1至C4烷基；或者3至14个碳原子的支链或直链环烷基，包括3至12个环碳原子，它们的单烯基醚，双烯基醚或其混合物。
• SUBSTITUTED CYCLOALKENE DERIVATIVE
  申请人：Kimura Tomio

  公开号：US20090233952A1

  公开（公告）日：2009-09-17

  [Object] To provide a substituted cycloalkene derivative having an action to suppress intracellular signal transduction or cell activation induced by endotoxin and to suppress cell responses due to the intracellular signal transduction and cell activation such as an excess generation of inflammatory mediators such as TNF-α, pharmacologically acceptable salts therefor, a medicament containing them as an active ingredient, a preparation method therefor, and a medicament containing the aforementioned substituted cycloalkene derivative as an active ingredient which is superior in prophylaxis and/or treatment of diseases such as sepsis (septic shock, disseminated intravascular coagulation, multiple organ failure and the like), that are associated with intracellular signal transduction or cell activation induced by endotoxin and to cell responses to the intracellular signal transduction and cell activation. [Solution] A compound represented by the general formula (I): wherein X and Y represent a group in which X and Y together with a carbon atom to which they are bound form ring A (the ring is 3- to 7-membered heterocyclyl ring or 3- to 7-membered cycloalkyl ring), each represents a hydrogen atom, or X and Y together represent a substituent of ring B. l and m, independently from each other, represent an integer of 0 to 3, and l+m is 1 to 3. R 1 is an aliphatic hydrocarbon group and the like which may be substituted with a group selected from Substituent group β and Substituent group γ. n represents an integer of 0 to 3. R 2 is a C 1 -C 6 alkyl group and the like which may be substituted with a group selected from a hydrogen atom and Substituent group β. R 3 is a phenyl group, 5- to 6-membered heteroaryl group and the like which may be substituted with a group selected from Substituent group ε. R 5 is a C 1 -C 6 alkyl group and the like which may be substituted with a group selected from a hydrogen atom and Substituent group β. Provided that in the case where R 3 is a phenyl group which may be substituted with a group selected from Substituent group ε, X and Y represent a group in which X and Y together with a carbon atom to which they are bound form ring A, or X and Y together represent a substituent of ring B.

  [目的] 提供一种替代环烯烃衍生物，具有抑制内毒素诱导的细胞内信号传导或细胞活化并抑制细胞对细胞内信号传导和细胞活化的反应，例如过量生成TNF-α等炎症介质，其药理学上可接受的盐，包含其作为活性成分的药物，其制备方法以及含有上述替代环烯烃衍生物作为活性成分的药物，其在预防和/或治疗与内毒素诱导的细胞内信号传导或细胞活化以及对细胞内信号传导和细胞活化的反应有关的疾病，例如败血症（败血性休克，弥漫性血管内凝血，多器官衰竭等）方面具有优越性。 [解决方案] 一种由通式（I）表示的化合物：其中，X和Y表示与它们结合的碳原子形成环A（环为3-至7成员的杂环或3-至7成员的环烷基环）的基团，每个表示氢原子，或X和Y一起表示环B的取代基。l和m，独立地，表示0至3的整数，且l+m为1至3。R1是脂肪烃基等，可以被从取代基组β和取代基组γ中选择的基团取代。n表示0至3的整数。R2是C1-C6烷基等，可以被从氢原子和取代基组β中选择的基团取代。R3是苯基，5-至6成员的杂环基等，可以被从取代基组ε中选择的基团取代。R5是C1-C6烷基等，可以被从氢原子和取代基组β中选择的基团取代。但在R3是苯基且可以被从取代基组ε中选择的基团取代的情况下，X和Y表示与它们结合的碳原子形成环A的基团，或X和Y一起表示环B的取代基。
• Synthesis and Insecticidal Activity Study of Azidopyridryl Containing Dichlorolpropene Ether Derivatives
  作者：Shao-meng Zhou、Zhen-yu Wang、Xiao-hui Zhu、Qiong-you Wu、Guang-Fu Yang

  DOI：10.1021/acs.jafc.3c02251

  日期：2023.11.29

  Pyridalyl, as a novel insecticide with an unknown mode of action, has shown excellent control efficacy against lepidopterous larvae and thrips. Previous modifications of this compound have mostly focused on the pyridine moiety, with limited information available about modifications to other parts of pyridalyl. In this paper, we report the synthesis and insecticidal activity of a series of azidopyridryl-containing

  Pyridalyl作为一种作用方式未知的新型杀虫剂，对鳞翅目幼虫和蓟马表现出优异的防治效果。以前对该化合物的修饰主要集中在吡啶部分，有关吡啶基其他部分修饰的信息有限。在本文中，我们报道了一系列基于吡啶基中间烷基链修饰的含叠氮吡啶基的二氯丙烯醚衍生物的合成和杀虫活性。杀虫活性筛选结果表明，我们合成的化合物在测试浓度下对小菜蛾表现出中等到高活性。特别是，化合物III-10的LC 50值为0.831 mg L –1，而吡啶啶的LC 50值为2.021 mg L –1。此外，化合物III-10还对鳞翅目害虫M. separata、二化螟、O. nubilalis和C. medinalis表现出相对广泛的杀虫谱。最后，在田间试验中，与吡啶啶相比，III-10对二化螟具有更好的防治效果。总的来说，我们的研究结果表明，吡啶基中间烷基链的修饰可能是开发具有更高功效的杀虫剂的有前途的方法。