6-deoxy-L-idose | 73-34-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-deoxy-L-idose
• 英文别名: L-Rhamnose；(3R,4S,5S,6S)-6-methyloxane-2,3,4,5-tetrol
• CAS: 73-34-7；87-96-7；488-79-9；551-63-3；609-01-8；643-17-4；643-18-5；4164-09-4；6014-42-2；6155-36-8；6189-71-5；6696-41-9；6736-43-2；13224-93-6；22611-09-2；28161-49-1；28161-50-4；28161-52-6；45864-36-6；63814-64-2；71116-59-1；71116-61-5；72598-05-1；87936-88-7；87936-89-8；97466-79-0；116908-82-8；120442-60-6；123484-22-0；133576-32-6
• 化学式: C₆H₁₂O₅
• 分子量: 164.158
• InChiKey: SHZGCJCMOBCMKK-ZNVMLXAYSA-N

物化性质

• 熔点：
  144.5-145 °C
• 沸点：
  323.9±42.0 °C(Predicted)
• 密度：
  1.556±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  90.2
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-deoxy-L-idose 在 sodium tetrahydroborate 作用下， 以 水 为溶剂， 反应 15.0h， 生成 1-deoxy-D-iditol
  参考文献：
  名称：

  Characterization of 6-deoxy-d-altritol in the cell-wall polysaccharide of Nocardia asteroides R 399

  摘要：

  A polyol, found in the cell-wall of Nocardia asteroides R 399 as a component of a neutral polysaccharide mainly composed of D-arabinose and D-galactose, was identified by mass spectrometry, paper chromatography, thin-layer chromatography, and gas chromatography as 6-deoxy-D-altritol.

  DOI：

  10.1016/s0008-6215(00)90459-2
• 作为产物：
  描述：

  1-[(2R,3R,4R)-3,4,5-triacetyloxyoxolan-2-yl]ethyl benzoate 生成 6-deoxy-L-idose
  参考文献：
  名称：

  LERNER, L. M.;SHOID, B.;GAETJENS, E., J. MED. CHEM., 30,(1987) N 8, 1521-1525

  摘要：

  DOI：

文献信息

• Synthesis of 6-deoxy-l-idose and l-acovenose from 1,2:5,6-di-O-isopropylidene-α-d-glucofuranose
  作者：Shang-Cheng Hung、Shankar R. Thopate、Ramachandra Puranik

  DOI：10.1016/s0008-6215(01)00058-1

  日期：2001.4

  -idose and l -acovenose from 1,2:5,6-di- O -isopropylidene-α- d -glucofuranose is described. Key steps include the stereoselective hydrogenation of 6-deoxy-1,2:3,5-di- O -isopropylidene-α- d - xylo -hex-5-enofuranose, regioselective protection of 6-deoxy-1,2- O -isopropylidene-β- l -idofuranose at O-5, and epimerisation of 6-deoxy-5- O - tert -butyldimethylsilyl-1,2- O -isopropylidene-β- l -idofuranose

  摘要描述了一种由1,2：5,6-二-O-异亚丙基-α-d-葡糖呋喃糖合成6-脱氧-1-糖和1-椰油糖的实用途径。关键步骤包括6-脱氧-1,2：3,5-二-O-异亚丙基-α-d-二甲苯基-hex-5-异呋喃糖的立体选择性加氢，6-脱氧-1,2-O-的区域选择性保护。 O-5处的异亚丙基-β-1-呋喃糖，C-3处6-脱氧-5-O-叔丁基二甲基甲硅烷基-1，2-O-异亚丙基-β-1-呋喃糖的差向异构化。
• METHOD FOR THE TREATMENT OF KERATIN MATERIALS USING ACID, ESTER OR AMIDE C-GLYCOSIDE DERIVATIVES, AND COSMETIC COMPOSITION CONTAINING SAME
  申请人：L'OREAL

  公开号：US20190263770A1

  公开（公告）日：2019-08-29

  The present invention relates to a method for the cosmetic treatment of keratin materials, in particular the skin, comprising the application of a composition to the keratin materials, such as the skin, said composition comprising a compound (I), wherein R is as defined in the description and S* is a mono or polysaccharide. In particular, the invention relates to the non-therapeutic cosmetic use of at least one compound of formula (I) as an agent for whitening, lightening and/or depigmenting keratin materials, such as the skin.

  本发明涉及一种用于角蛋白材料的化妆处理的方法，特别是皮肤，包括将一种组合物应用于角蛋白材料，如皮肤，所述组合物包括一种化合物(I)，其中R如描述中定义，S*是单糖或多糖。具体而言，该发明涉及至少一种具有式(I)的化合物的非治疗性化妆用途，作为美白、淡化和/或脱色角蛋白材料，如皮肤的剂。
• Preparation and antileukemic screening of some new 6'-deoxyhexopyranosyladenine nucleosides
  作者：Leon M. Lerner、Bertrum Sheid、Eric Gaetjens

  DOI：10.1021/jm00391a044

  日期：1987.8

  for activity. The new nucleosides were 9-(6-deoxy-beta-D-glucopyranosyl)adenine (2), 9-(6-deoxy-beta-D-allopyranosyl)adenine (3), 9-(6-deoxy-alpha-L-talopyranosyl)adenine (4), 9-alpha-D-rhamnopyranosyladenine (5), and 9-(6-deoxy-alpha-L-idopyranosyl)adenine (6). In addition, 9-(6-deoxy-alpha-L-sorbofuranosyl)adenine (7) was isolated from the same preparation as 6. None of the new nucleosides 2-7 had

  9-β-D-富勒索糖基腺嘌呤（1）对培养物中生长的L1210细胞的抗白血病活性较弱。通过标准程序合成了几种新的6'-脱氧己吡喃糖基腺嘌呤核苷，并对其活性进行了测定。新的核苷是9-（6-脱氧-β-D-吡喃葡萄糖基）腺嘌呤（2），9-（6-脱氧-β-D-戊吡喃糖基）腺嘌呤（3），9-（6-脱氧-α-L -talopyranosyl）腺嘌呤（4），9-α-D-鼠李糖吡喃糖基腺嘌呤（5）和9-（6-脱氧-α-L-idopyranosyl）腺嘌呤（6）。另外，从与6相同的制剂中分离出9-（6-脱氧-α-L-山梨糖醛酸基）腺嘌呤（7）。新的核苷2-7都没有抗培养中的L1210细胞的活性。还测试了许多与结构相关的其他已知核苷的活性。其中一种9-α-L-阿拉伯吡喃型腺嘌呤腺苷具有活性，但明显弱于1。
• Synthesis of an unusual branched-chain sugar, 5-C-methyl-l-idopyranose for SAR studies of pyranmycins: implication for the future design of aminoglycoside antibiotics
  作者：Jinhua Wang、Jie Li、Przemyslaw G. Czyryca、Huiwen Chang、Jeff Kao、Cheng-Wei Tom Chang

  DOI：10.1016/j.bmcl.2004.06.064

  日期：2004.9

  The syntheses of a challenging branched-chain sugar and several L-sugars have been accomplished. Their application in studies of the antibacterial activity of pyranmycins is reported, which could provide new strategies for the future design of aminoglycoside antibiotics. (C) 2004 Elsevier Ltd. All rights reserved.
• KARAMANOS, N. K.;HJERPE, A.;TSEGENIDIS, T.;ENGFELDT, B.;ANTONOPOULOS, C. +, ANAL. BIOCHEM., 172,(1988) N 2, 410-419
  作者：KARAMANOS, N. K.、HJERPE, A.、TSEGENIDIS, T.、ENGFELDT, B.、ANTONOPOULOS, C. +

  DOI：——

  日期：——