1-(2,2-dimethoxy-2-phenylethyl)-piperidine-2,6-dione | 1246754-35-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2,2-dimethoxy-2-phenylethyl)-piperidine-2,6-dione
• 英文别名: 1-(2,2-Dimethoxy-2-phenylethyl)piperidine-2,6-dione
• CAS: 1246754-35-7
• 化学式: C₁₅H₁₉NO₄
• 分子量: 277.32
• InChiKey: KNUUOCIFZCKNCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-氯-1,2-丙二醇 、 1-(2,2-dimethoxy-2-phenylethyl)-piperidine-2,6-dione 在 三甲基氯硅烷 、 cobalt(II) chloride 作用下， 以 乙腈 为溶剂， 反应 21.0h， 生成 trans-1-(4-chloromethyl-2-phenyl-[1,3]dioxolan-2-ylmethyl)piperidine-2,6-dione 、 cis-1-(4-chloromethyl-2-phenyl-[1,3]dioxolan-2-ylmethyl)piperidine-2,6-dione
  参考文献：
  名称：

  1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: Structure–affinity/activity relationship at α1-adrenoceptor subtypes and at 5-HT1A receptors

  摘要：

  A series of 1,3-dioxolane-based compounds incorporating a lactam (2-4) or imide (5-7) moiety was synthesized and the pharmacological profile at alpha(1)-adrenoceptor subtypes and 5-HT1A receptor was assessed through binding and functional experiments. Starting from the 2,2-diphenyl-1,3-dioxolane derivative 1, previously shown to be a selective alpha(1a(A))/alpha(1d(D))-adrenoceptor subtype antagonist, over alpha(1b(B)) subtype and 5-HT1A receptor, and replacing one phenyl ring with lactam or imide moiety a reduction of alpha(1)/5-H-1A selectivity is observed, mainly due to the increase in 5-H-1A affinity. In functional experiments lactam derivatives seems to favour 5-HT1A receptor antagonism (pKb = 7.20-7.80) and alpha(1B)-adrenoceptor antagonist selectivity (alpha(1B)/alpha(1A) and alpha(1B)/alpha(1D) of about 10-fold). The most interesting of the various imide derivatives is compound 7t, which is a selective alpha(1D)-adrenoceptor antagonist (pKb = 8.1 and alpha(1D)/alpha(1A) and alpha(1D)/alpha(1B) selectivity ratios of 16 and 11 respectively) whereas at 5-HT1A receptor it is a potent partial agonist (pD2 = 7.98, E-max = 60%).]. Given that as and trans diastereomer pairs for 2-7 are possible, a computational strategy based on molecular docking studies was used to elucidate the atomic details of the 5-HT1A/agonist and 5-HT1A/antagonist interaction. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.05.023
• 作为产物：
  描述：

  1-(2-oxo-2-phenylethyl)-piperidine-2,6-dione 、 原甲酸三甲酯 在 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 反应 23.0h， 生成 1-(2,2-dimethoxy-2-phenylethyl)-piperidine-2,6-dione
  参考文献：
  名称：

  1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: Structure–affinity/activity relationship at α1-adrenoceptor subtypes and at 5-HT1A receptors

  摘要：

  A series of 1,3-dioxolane-based compounds incorporating a lactam (2-4) or imide (5-7) moiety was synthesized and the pharmacological profile at alpha(1)-adrenoceptor subtypes and 5-HT1A receptor was assessed through binding and functional experiments. Starting from the 2,2-diphenyl-1,3-dioxolane derivative 1, previously shown to be a selective alpha(1a(A))/alpha(1d(D))-adrenoceptor subtype antagonist, over alpha(1b(B)) subtype and 5-HT1A receptor, and replacing one phenyl ring with lactam or imide moiety a reduction of alpha(1)/5-H-1A selectivity is observed, mainly due to the increase in 5-H-1A affinity. In functional experiments lactam derivatives seems to favour 5-HT1A receptor antagonism (pKb = 7.20-7.80) and alpha(1B)-adrenoceptor antagonist selectivity (alpha(1B)/alpha(1A) and alpha(1B)/alpha(1D) of about 10-fold). The most interesting of the various imide derivatives is compound 7t, which is a selective alpha(1D)-adrenoceptor antagonist (pKb = 8.1 and alpha(1D)/alpha(1A) and alpha(1D)/alpha(1B) selectivity ratios of 16 and 11 respectively) whereas at 5-HT1A receptor it is a potent partial agonist (pD2 = 7.98, E-max = 60%).]. Given that as and trans diastereomer pairs for 2-7 are possible, a computational strategy based on molecular docking studies was used to elucidate the atomic details of the 5-HT1A/agonist and 5-HT1A/antagonist interaction. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.05.023

文献信息

• 1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: Structure–affinity/activity relationship at α1-adrenoceptor subtypes and at 5-HT1A receptors
  作者：Silvia Franchini、Adolfo Prandi、Annamaria Baraldi、Claudia Sorbi、Annalisa Tait、Michela Buccioni、Gabriella Marucci、Antonio Cilia、Lorenza Pirona、Paola Fossa

  DOI：10.1016/j.ejmech.2010.05.023

  日期：2010.9

  A series of 1,3-dioxolane-based compounds incorporating a lactam (2-4) or imide (5-7) moiety was synthesized and the pharmacological profile at alpha(1)-adrenoceptor subtypes and 5-HT1A receptor was assessed through binding and functional experiments. Starting from the 2,2-diphenyl-1,3-dioxolane derivative 1, previously shown to be a selective alpha(1a(A))/alpha(1d(D))-adrenoceptor subtype antagonist, over alpha(1b(B)) subtype and 5-HT1A receptor, and replacing one phenyl ring with lactam or imide moiety a reduction of alpha(1)/5-H-1A selectivity is observed, mainly due to the increase in 5-H-1A affinity. In functional experiments lactam derivatives seems to favour 5-HT1A receptor antagonism (pKb = 7.20-7.80) and alpha(1B)-adrenoceptor antagonist selectivity (alpha(1B)/alpha(1A) and alpha(1B)/alpha(1D) of about 10-fold). The most interesting of the various imide derivatives is compound 7t, which is a selective alpha(1D)-adrenoceptor antagonist (pKb = 8.1 and alpha(1D)/alpha(1A) and alpha(1D)/alpha(1B) selectivity ratios of 16 and 11 respectively) whereas at 5-HT1A receptor it is a potent partial agonist (pD2 = 7.98, E-max = 60%).]. Given that as and trans diastereomer pairs for 2-7 are possible, a computational strategy based on molecular docking studies was used to elucidate the atomic details of the 5-HT1A/agonist and 5-HT1A/antagonist interaction. (C) 2010 Elsevier Masson SAS. All rights reserved.