1,2,3-Trimethyl-1,4-dihydroquinoline | 89317-59-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1,2,3-Trimethyl-1,4-dihydroquinoline
• 英文别名: 1,2,3-trimethyl-4H-quinoline
• CAS: 89317-59-9
• 化学式: C₁₂H₁₅N
• 分子量: 173.25
• InChiKey: BSAUVWPKEQLQOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Novel 1-2-Dihydroquinoline Derivative Having Glucocorticoid Receptor Binding Activity
  申请人：Matsuda Mamoru

  公开号：US20090326009A1

  公开（公告）日：2009-12-31

  An object of the present invention is to study synthesis of a novel 1,2-dihydroquinoline derivative and to find a pharmacological action of the derivative. A compound represented by the general formula (1) or a salt thereof is effective in the treatment of a glucocorticoid receptor-related disease. In the formula, the ring X represents a benzene ring or a pyridine ring; R 1 represents a halogen atom, an alkyl group, a hydroxy group, an alkoxy group, an amino group or the like; p represents an integer of 0 to 5; R 2 represents a halogen atom, an alkyl group, a hydroxy group or the like; q represents an integer of 0 to 2; R 3 represents a hydrogen atom, an alkyl group, an alkenyl group or the like; R 4 and R 5 represent a hydrogen atom or the like; R 6 represents a hydrogen atom or the like; A represents an alkylene group or the like; and R 7 represents OR 8 , NR 8 R 9 , SR 8 , S(O)R 8 or S(O) 2 R 8 , wherein R 8 represents an aryl group, a heterocyclic group or the like and R 9 represents a hydrogen atom or the like.

  本发明的目的是研究合成一种新型1,2-二氢喹啉衍生物，并发现该衍生物的药理作用。通式（1）表示的化合物或其盐在治疗糖皮质激素受体相关疾病方面具有有效性。在该式中，环X表示苯环或吡啶环；R1表示卤素原子、烷基、羟基、烷氧基、氨基或类似物；p表示0至5的整数；R2表示卤素原子、烷基、羟基或类似物；q表示0至2的整数；R3表示氢原子、烷基、烯基或类似物；R4和R5表示氢原子或类似物；R6表示氢原子或类似物；A表示烷基链或类似物；R7表示OR8、NR8R9、SR8、S（O）R8或S（O）2R8，其中R8表示芳基、杂环基或类似物，R9表示氢原子或类似物。
• Laminate and self-adhesive tape
  申请人：IDEMITSU PETROCHEMICAL CO. LTD.

  公开号：EP0494619A2

  公开（公告）日：1992-07-15

  There are disclosed a laminate comprising (a) a biaxially oriented film of a styrenic polymer having a high degree of syndiotactic configuration of 10 to 100 µm in thickness and (b) a rubber-based self-adhesive layer of 5 to 80 m in thickness and a self-adhesive tape comprising the above-mentioned laminate. The above laminate and self-adhesive tape are excellent in transparency, heat resistance, water resistance, moisture resistance, dispenser and hand cuttability, insulating properties and mechanical properties such as elasticity and nerve and can find a wide range of effective application.

  本发明公开了一种层压板，包括(a)厚度为 10 至 100 微米的具有高度对偶构造的苯乙烯聚合物双向拉伸薄膜和(b)厚度为 5 至 80 米的橡胶基自粘层，以及包括上述层压板的自粘胶带。上述层压板和自粘胶带在透明度、耐热性、耐水性、防潮性、可分配性和手剪性、绝缘性以及弹性和神经等机械性能方面都非常出色，可以找到广泛的有效应用。
• DETERGENT COMPOSITION
  申请人：The Procter & Gamble Company

  公开号：EP3816271A1

  公开（公告）日：2021-05-05

  The need for a hand-dishwashing composition which provides good sudsing and a good suds profile even in the presence of greasy stains comprising higher chain-length saturated and/or unsaturated fatty acid chains, as well as improved removal of such stains, is met by formulating the composition with a P450 fatty acid decarboxylase and a surfactant system.

  我们需要一种洗手液组合物，即使在含有更高链长的饱和和/或不饱和脂肪酸链的油脂污渍存在时，也能提供良好的起泡性和起泡特性，并能更好地去除这些污渍，这种组合物的配方中加入了 P450 脂肪酸脱羧酶和表面活性剂系统。
• NOVEL 1-2-DIHYDROQUINOLINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY
  申请人：SANTEN PHARMACEUTICAL CO., LTD.

  公开号：EP1944290B1

  公开（公告）日：2013-12-04
• THERMAL STABILIZED RESIN COMPOSITIONS
  申请人：KOLON INDUSTRIES, INC.

  公开号：EP0737231B1

  公开（公告）日：2000-03-08