2,2,8,8-tetramethyl-5-nonanone | 5709-95-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2,8,8-tetramethyl-5-nonanone
• 英文别名: 2,2,8,8-tetramethyl-nonan-5-one；2,2,8,8-Tetramethyl-nonan-5-on；2,2,8,8-Tetramethylnonane-5-one；2,2,8,8-tetramethylnonan-5-one
• CAS: 5709-95-5
• 化学式: C₁₃H₂₆O
• 分子量: 198.349
• InChiKey: IGJHCSFIFSZTTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  甲醇 、 3,3-二甲基-1-丁烯 在 2-氨基-4-甲基吡啶 、 Wilkinson's catalyst 、 苯甲酸 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以76%的产率得到2,2,8,8-tetramethyl-5-nonanone
  参考文献：
  名称：

  Rhodium(i)-catalyzed one-pot synthesis of dialkyl ketones from methanol and alkenes through directed sp3 C–H bond activation of N-methylamine

  摘要：

  甲醇与烯类的水合酰化反应是利用由Rh(I)、2-氨基-4-吡啶和苯甲酸组成的催化体系开发的；该反应推测首先通过甲醇对2-氨基-4-吡啶进行N-甲基化，随后对产生的N-甲基胺进行脱氢反应，然后通过双配体辅助的烯类与亚胺的水合亚胺反应，最终在水解后生成二烷基酮。

  DOI：

  10.1039/b814166e

文献信息

• SULFAMIDE DERIVATIVE HAVING AN ADAMANTYL GROUP AND ITS PHARMACEUTICALLY ACCEPTABLE SALT
  申请人：Kim Ki Young

  公开号：US20140024636A1

  公开（公告）日：2014-01-23

  Provided is a sulfamide derivative having an adamantyl group represented by the following Formula 1, or a pharmaceutically acceptable salt thereof. The sulfamide derivative suppresses the activity of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), and is useful in the treatment of various diseases that are mediated by 11β-HSD1.

  提供一个具有金刚烷基团的磺酰胺衍生物，其由以下公式1表示，或其药物可接受的盐。该磺酰胺衍生物抑制11β-羟基类固醇脱氢酶1（11β-HSD1）的活性，并且在治疗由11β-HSD1介导的各种疾病中是有用的。
• Chelation-Assisted C–H and C–C Bond Activation of Allylic Alcohols by a Rh(I) Catalyst under Microwave Irradiation
  作者：Chul-Ho Jun、Chang-Hee Lee

  DOI：10.1055/s-0036-1591697

  日期：2018.4

  Chelation-assisted Rh(I)-catalyzed ketone synthesis from allylic alcohols and alkenes through C–H and C–C bond activations under microwave irradiation was developed. Aldimine is formed via olefin isomerization of allyl alcohol under Rh(I) catalysis and condensation with 2-amino-3-picoline, followed by continuous C–H and C–C bond activations to produce a dialkyl ketone. The addition of piperidine accelerates

  开发了螯合辅助的 Rh(I) 催化的酮，通过微波辐射下的 C-H 和 C-C 键活化，由烯丙醇和烯烃合成。醛亚胺是通过烯丙醇在 Rh(I) 催化下的烯烃异构化和与 2-amino-3-picoline 缩合形成的，然后连续的 C-H 和 C-C 键活化产生二烷基酮。哌啶的加入通过在微波条件下促进醛亚胺的形成来加速反应速率。
• Process for producing alcohols and ketones
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0531715A1

  公开（公告）日：1993-03-17

  The present invention provides a process for the oxidation of straight-chain, branched-chain or cyclic alkanes of 1-20 carbon atoms and benzene derivatives represented by the following formulas (1) - (2). The alcohols and ketones obtained by the oxidation of the alkanes mentioned above and those by the oxidation of the benzene derivatives mentioned above represented by the following formulas (3) - (6) are important as basic starting materials in producing various chemical products including resins, such as nylon and polyester, pharmaceuticals, agricultural chemicals, perfumes, dyes, etc.

  本发明提供了一种氧化 1-20 个碳原子的直链、支链或环状烷烃以及由下列式子 (1) - (2) 表示的苯衍生物的工艺。由上述烷烃氧化得到的醇和酮以及由下列式子（3）-（6）表示的上述苯衍生物氧化得到的醇和酮是生产各种化学产品的重要基本起始原料，包括树脂（如尼龙和聚酯）、药品、农药、香水、染料等。
• Chemically amplified positive photoresist composition and pattern forming method using same
  申请人：Ridgefield Acquisition

  公开号：US11029599B2

  公开（公告）日：2021-06-08

  The present invention relates to a photosensitive resin composition suitable for forming a thick film, which comprises (A) an alkali-soluble resin, (B) at least one plasticizer selected from a group consisting of an alkali-soluble vinyl resin and an acid-dissociable group containing vinyl resin, (C) an acid generator, and (D) an organic solvent.

  本发明涉及一种适用于形成厚膜的感光树脂组合物，该组合物包括：(A) 碱溶性树脂；(B) 至少一种增塑剂，该增塑剂选自碱溶性乙烯基树脂和含酸解离基团的乙烯基树脂组成的组；(C) 酸发生剂；(D) 有机溶剂。
• C−H and C−C Bond Activation of Primary Amines through Dehydrogenation and Transimination
  作者：Chul-Ho Jun、Kwan-Yong Chung、Jun-Bae Hong

  DOI：10.1021/ol015563+

  日期：2001.3.1

  [GRAPHICS]Dehydrogenation and subsequent transimination of primary amines offer a new pathway for C-H bond activation, ortho-alkylation, and C-C bond activation to afford a variety of ketones in the reaction of l-alkene by a cocatalyt system of Rh(I) and 2-amino-3-picoline.