2-ethoxy-1-hexene | 54844-02-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-ethoxy-1-hexene
• 英文别名: 2-ethoxy-hex-1-ene；ethyl-(1-butyl-vinyl)-ether；Aethyl-(1-butyl-vinyl)-aether；2-Aethoxy-hexen-(1)；1-Hexene, 2-ethoxy-；2-ethoxyhex-1-ene
• CAS: 54844-02-9
• 化学式: C₈H₁₆O
• 分子量: 128.214
• InChiKey: FWIPMQKCXHTVBB-UHFFFAOYSA-N

物化性质

• 沸点：
  132-133 °C
• 密度：
  0.797 g/cm3(Temp: 23 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-ethoxy-1-hexene 在 mercury(II) diacetate 、 mercury(II) oxide 作用下， 生成 1,1'-mercurio-bis-hexan-2-one
  参考文献：
  名称：

  Luzenko; Chomutow, Doklady Akademii Nauk SSSR, 1955, vol. 102, p. 97

  摘要：

  DOI：
• 作为产物：
  描述：

  1-溴-2-乙氧基己烷 在 吡啶 、 对苯二酚 作用下， 以 N-甲基乙酰胺 、 水 、 异丙醇 、 mineral oil 为溶剂， 生成 2-ethoxy-1-hexene
  参考文献：
  名称：

  15-Deoxy-16-hydroxy-16-(1'fluorovinyl) prostaglandins and derivatives

  摘要：

  已制备出15-去氧-16-(卤代乙烯基)-16-羟基前列腺素。

  公开号：

  US04404393A1

文献信息

• 1-Substituted-1-oxo-prostane-derivatives of the E, A and F series
  申请人：American Cyanamid Company

  公开号：US04297516A1

  公开（公告）日：1981-10-27

  The invention disclosed herein relates to pharmacologically active prostaglandin derivatives of the E, F, or A series having on the terminal methylene carbon of the alpha chain, a substituent selected from the group consisting of: ##STR1## wherein R is C.sub.1 to C.sub.6 alkyl, and phenyl or phenyl substituted with one or more substituents selected from the group consisting of C.sub.1 -C.sub.4 alkyl, OR.sub.16, SR.sub.16, F, or Cl, and R.sub.16 is C.sub.1 to C.sub.6 alkyl.

  本发明公开的药物活性前列腺素衍生物属于E、F或A系列，在α链的末端亚甲基碳上有一个取代基，该取代基从以下组中选择：##STR1## 其中R是C.sub.1至C.sub.6烷基，和苯基或苯基，苯基上带有1个或多个取代基，该取代基从以下组中选择：C.sub.1-C.sub.4烷基，OR.sub.16，SR.sub.16，F或Cl，R.sub.16是C.sub.1至C.sub.6烷基。
• 1-Hydroxymethyl-1-oxo-prostane-derivatives of the E, A and F-series
  申请人：American Cyanamid Company

  公开号：US04254036A1

  公开（公告）日：1981-03-03

  The invention disclosed herein relates to pharmacologically active prostaglandin derivatives of the E, F, or A series having on the terminal methylene carbon of the alpha chain a substituent selected from the group consisting of: ##STR1## wherein R is an alkyl group and R.sub.15 is C.sub.1 -C.sub.4 alkyl, di-C.sub.1 -C.sub.4 -alkylamino, C.sub.1 -C.sub.4 alkoxy, and phenyl or phenyl substituted with one or more substituents from the group consisting of C.sub.1 -C.sub.4, OR, SR, F, or Cl wherein R is as previously defined.

  本发明涉及具有在α链的末端亚甲基碳上选择自以下组成的取代基的E、F或A系列药理活性前列腺素衍生物：##STR1##其中R是烷基基团，R.sub.15是C.sub.1 -C.sub.4烷基，二C.sub.1 -C.sub.4-烷基氨基，C.sub.1 -C.sub.4烷氧基，苯基或苯基，其上取代基来自C.sub.1 -C.sub.4，OR，SR，F或Cl的组成，其中R如前所定义。
• 1-Hydroxymethyl-1-oxo-prostane derivatives of the E, A and F series
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0015056A1

  公开（公告）日：1980-09-03

  The invention disclosed relates to pharmacologically active prostaglandin derivates of the E, F, or A series having on the terminal methylene carbon of the alpha chain a substituent selected from the group consisting of: wherein R is an alkyl group and R13 is C1-C4 alkyl, di-C,-C. -alkylamino, C1-C4 alkoxy, and phenyl or phenyl substituted with one or more substituents from the group consisting of C1-C4, OR, SR, F, or Cl wherein R is as previously defined.

  本发明涉及具有药理活性的 E、F 或 A 系列前列腺素衍生物，其 α 链的末端亚甲基碳上具有选自以下组别的取代基： 其中 R 是烷基，R13 是 C1-C4 烷基、二-C,-C.-烷基氨基、C1-C4 烷氧基和苯基或被一个或多个取代基取代的苯基，取代基可从 C1-C4、OR、SR、F 或 Cl 组成的组中选出，其中 R 如前定义。
• Eglinton et al., Journal of the Chemical Society, 1952, p. 2873,2880
  作者：Eglinton et al.

  DOI：——

  日期：——
• Enol ethers and acetals: acylation with dichloroacetyl, acetyl and benzoyl chloride in ionic liquid medium
  作者：Emerson A. Guarda、Mara R.B. Marzari、Clarissa P. Frizzo、Patrícia M. Guarda、Nilo Zanatta、Helio G. Bonacorso、Marcos A.P. Martins

  DOI：10.1016/j.tetlet.2011.10.163

  日期：2012.1

  Synthesis of 4-alkoxy-1,1-dichloro-3-alken-2-ones [CHCl2C(O)C(R-2=C(R-1)-OR, where R, R-1, R-2 = Et, H, H; Me, Me, H; Et, H, Me; Me, -(CH2)(2)-; Me, -(CH2)(3)-; Et, Et, H; Et, Bu, H; Et, i-Pr, H; Et, i-Bu, H; Me, Ph, H; Me, thien-2-yl, H] from acylation of enol ethers and acetals with dichloroacetyl chloride, in ionic liquid ([BMIM]BF4] or [BMIM][PF6]) is reported. The synthesis of alkenones [R-3-C(O)C(R-2=C(R1)-OR], where R/R-1/R-2/R-3 = Et/H/H/Ph, t-Bu/H/H/Ph, Me/-(CH2)(4)/Ph. Me/-(CH2)(4)/Me] from the reaction of enol ethers with benzoyl chloride or acetyl chloride, in ionic liquid [BMIM][BF4], is also reported. Last products are described for the first time. (C) 2011 Elsevier Ltd. All rights reserved.