4-(2-thienyl)thiazole-2-thiocarboxamide | 150280-29-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(2-thienyl)thiazole-2-thiocarboxamide
• 英文别名: 4-Thiophen-2-yl-1,3-thiazole-2-carbothioamide
• CAS: 150280-29-8
• 化学式: C₈H₆N₂S₃
• 分子量: 226.347
• InChiKey: GDLBJBNVFURRNP-UHFFFAOYSA-N

物化性质

• 沸点：
  418.4±37.0 °C(Predicted)
• 密度：
  1.474±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  128
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-phenyl-2-(p-tolylsulfonyloxy)ethanone 、 4-(2-thienyl)thiazole-2-thiocarboxamide 以 乙醇 为溶剂， 反应 4.0h， 以71%的产率得到4-Phenyl-2-[4-(thiophen-2-YL)-1,3-thiazol-2-YL]-1,3-thiazole
  参考文献：
  名称：

  A CONVENIENT SYNTHESIS OF 4-SUBSTITUTED-4′-(2-THIENYL)- 2,2′-BITHIAZOLES AS POTENTIAL PHOTOTOXIC AGENTS

  摘要：

  Alpha-tosyloxyacetylthiophene (3), obtained by the hypervalent iodine oxidation of 2-acetylthiophene (2) using [hydroxy(tosyloxy)iodo]benzene (HTIB), on treatment with rubeanic acid exclusively generates 4-(2-thienyl)thiazole-2-thiocarboxamide (4) which upon subsequent treatment with a variety of alpha-tosyloxyketones (5) affords the title compounds (G) in excellent yields.

  DOI：

  10.1081/scc-100108224
• 作为产物：
  描述：

  2-乙酰基噻吩 以 乙醇 、 乙腈 为溶剂， 反应 8.0h， 生成 4-(2-thienyl)thiazole-2-thiocarboxamide
  参考文献：
  名称：

  A CONVENIENT SYNTHESIS OF 4-SUBSTITUTED-4′-(2-THIENYL)- 2,2′-BITHIAZOLES AS POTENTIAL PHOTOTOXIC AGENTS

  摘要：

  Alpha-tosyloxyacetylthiophene (3), obtained by the hypervalent iodine oxidation of 2-acetylthiophene (2) using [hydroxy(tosyloxy)iodo]benzene (HTIB), on treatment with rubeanic acid exclusively generates 4-(2-thienyl)thiazole-2-thiocarboxamide (4) which upon subsequent treatment with a variety of alpha-tosyloxyketones (5) affords the title compounds (G) in excellent yields.

  DOI：

  10.1081/scc-100108224

文献信息

• Singh, S P; Ranjana, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1992, vol. 31, # 11, p. 782 - 783
  作者：Singh, S P、Ranjana

  DOI：——

  日期：——
• A CONVENIENT SYNTHESIS OF 4-SUBSTITUTED-4′-(2-THIENYL)- 2,2′-BITHIAZOLES AS POTENTIAL PHOTOTOXIC AGENTS
  作者：Shiv P. Singh、Rajesh Naithani、Ranjana Aggarwal、Om Prakash

  DOI：10.1081/scc-100108224

  日期：2001.1.1

  Alpha-tosyloxyacetylthiophene (3), obtained by the hypervalent iodine oxidation of 2-acetylthiophene (2) using [hydroxy(tosyloxy)iodo]benzene (HTIB), on treatment with rubeanic acid exclusively generates 4-(2-thienyl)thiazole-2-thiocarboxamide (4) which upon subsequent treatment with a variety of alpha-tosyloxyketones (5) affords the title compounds (G) in excellent yields.