[(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(2,4-difluorophenyl)tetrahydro-2H-pyran-4-yl]methanol | 1425947-62-1

分子结构分类

有机化合物 - 苯类化合物 - 苯和取代衍生物

中文名称

——

中文别名

——

英文名称

[(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(2,4-difluorophenyl)tetrahydro-2H-pyran-4-yl]methanol

英文别名

[(2R,4R,5S)-5-amino-5-(2,4-difluorophenyl)-2-(phenylmethoxymethyl)oxan-4-yl]methanol

[(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(2,4-difluorophenyl)tetrahydro-2H-pyran-4-yl]methanol化学式

CAS

1425947-62-1

化学式

C₂₀H₂₃F₂NO₃

mdl

——

分子量

363.404

InChiKey

SDFLUNRFKYHXHG-VPWXQRGCSA-N

BEILSTEIN

——

EINECS

——

计算性质

辛醇/水分配系数(LogP)：

2.4
重原子数：

26
可旋转键数：

6
环数：

3.0
sp3杂化的碳原子比例：

0.4
拓扑面积：

64.7
氢给体数：

2
氢受体数：

6

上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
——	(3aR,5R,7aS)-5-[(benzyloxy)methyl]-7a-(2,4-difluorophenyl)hexahydro-1H-pyrano[3,4-c][1,2]oxazole	1425947-61-0	C₂₀H₂₁F₂NO₃	361.388

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	(1S)-1-[(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(2,4-difluorophenyl)tetrahydro-2H-pyran-4-yl]ethanol	——	C₂₁H₂₅F₂NO₃	377.431
——	(±)-[(2S,4R,5S)-5-amino-2-(cyclopropylmethyl)-5-(2,4-difluorophenyl)tetrahydro-2-pyran-4-yl]methanol	——	C₁₆H₂₁F₂NO₂	297.345
——	(±)-[(2R,4R,5S)-5-amino-2-cyclopropyl-5-(2,4-difluorophenyl)tetrahydro-2H-pyran-4-yl]methanol	——	C₁₅H₁₉F₂NO₂	283.318
——	(±)-[(2R,4R,5S)-5-amino-5-(2,4-difluorophenyl)-2-(1-methylcyclopropyl)tetrahydro-2-pyran-4-yl]methanol	——	C₁₆H₂₁F₂NO₂	297.345
——	rel-(1R)-1-[(2R,4R,5S)-5-amino-2-cyclopropyl-5-(2,4-difluorophenyl)tetrahydro-2H-pyran-4-yl]-2-fluoroethanol	——	C₁₆H₂₀F₃NO₂	315.33
——	N-{[(3S,4R,6R)-6-[(benzyloxy)methyl]-3-(2,4-difluorophenyl)-4-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]carbamothioyl}benzamide	——	C₂₈H₂₈F₂N₂O₄S	526.604
——	{[(3S,4R,6R)-6-[(benzyloxy)methyl]-3-(2,4-difluorophenyl)-4-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]carbamothioyl}carbamate	1425947-63-2	C₃₆H₃₄F₂N₂O₅S	644.739
——	N-[(4aR,6R,8aS)-6-[(benzyloxy)methyl]-8a-(2,4-difluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]benzamide	——	C₂₈H₂₆F₂N₂O₃S	508.589
——	methyl (4aR,6R,8aS)-2-(benzoylamino)-8a-(2,4-difluorophenyl)-4,4-a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazine-6-carboxylate	——	C₂₂H₂₀F₂N₂O₄S	446.475
——	N-[(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(1-hydroxy-4-methylpent-4-en-1-yl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-c][1,3]thiazin-2-yl]benzamide	1616505-52-2	C₂₆H₂₈F₂N₂O₃S	486.583
——	3-oxobutan-2-yl (4aR,6R,8aS)-2-(benzoylamino)-8a-(2,4-difluorophenyl)-4,4-a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazine-6-carboxylate	——	C₂₅H₂₄F₂N₂O₅S	502.539
——	(4aR,6R,8aS)-2-(benzoylamino)-8a-(2,4-difluorophenyl)-4,4-a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazine-6-carboxylic acid	——	C₂₁H₁₈F₂N₂O₄S	432.448
——	N-[(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(1-hydroxyprop-2-yn-1-yl)-4,4-a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]benzamide	——	C₂₃H₂₀F₂N₂O₃S	442.486
——	N-[(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(1-hydroxyprop-2-yn-1-yl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]benzamide	1480185-07-6	C₂₃H₂₀F₂N₂O₃S	442.486
——	(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(4-fluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine	1622327-94-9	C₁₉H₁₇F₃N₂OS	378.418
——	N-[(4aR,6R,8aS)-6-cyano-8a-(2,4-difluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]benzamide	1621585-65-6	C₂₁H₁₇F₂N₃O₂S	413.448
——	N-[(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-formyl-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]benzamide	——	C₂₁H₁₈F₂N₂O₃S	416.448
——	4-[(4aR,6R,8aS)-2-amino-8a-(2,4-difluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-6-yl]benzonitrile	1622328-24-8	C₂₀H₁₇F₂N₃OS	385.437
——	N-[(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(1,1,3,3-tetramethoxypropan-2-yl)-4,4-a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]benzamide	——	C₂₇H₃₂F₂N₂O₆S	550.624
——	(4aR,6R,8aS)-2-(benzoylamino)-8a-(2,4-difluorophenyl)-4,4-a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazine-6-carboxamide	——	C₂₁H₁₉F₂N₃O₃S	431.463
——	N-[(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(prop-2-ynoyl)-4,4-a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]benzamide	——	C₂₃H₁₈F₂N₂O₃S	440.47
——	(4aR,6R,8aS)-2-(benzoylamino)-8a-(2,4-difluorophenyl)-N-(2,2-dimethoxyethyl)-4,4-a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazine-6-carboxamide	——	C₂₅H₂₇F₂N₃O₅S	519.569
——	N-[(4aR,6R,8aS)-6-(bromoacetyl)-8a-(2,4-difluorophenyl)-4,4-a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]benzamide	——	C₂₂H₁₉BrF₂N₂O₃S	509.371
——	(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(5-fluoropyridin-3-yl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine	1621585-38-3	C₁₈H₁₆F₃N₃OS	379.406
——	(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(1-methyl-1H-pyrazol-4-yl)-4,4-a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine	——	C₁₇H₁₈F₂N₄OS	364.419
——	(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(2-methoxypyridin-4-yl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine	1621585-34-9	C₁₉H₁₉F₂N₃O₂S	391.442
——	(4aR,6R,8aS)-2-(benzoylamino)-8a-(2,4-difluorophenyl)-N-(4-hydroxypyridin-3-yl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazine-6-carboxamide	1621585-77-0	C₂₆H₂₂F₂N₄O₄S	524.548
——	N-[(4aR,6R,8aS)-6-(4-cyanophenyl)-8a-(2,4-difluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]benzamide	1669434-23-4	C₂₇H₂₁F₂N₃O₂S	489.545
——	5-[(4aR,6R,8aS)-2-amino-8a-(2,4-difluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-6-yl]-1-methylpyridin-2(1H)-one	1621585-11-2	C₁₉H₁₉F₂N₃O₂S	391.442
——	(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(5-fluoropyridin-2-yl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine	1621585-10-1	C₁₈H₁₆F₃N₃OS	379.406
——	N-[(4aR,8aS)-8a-(2,4-difluorophenyl)-6-oxo-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]benzamide	——	C₂₀H₁₆F₂N₂O₃S	402.421
——	(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(5-fluoro-1-methyl-1H-pyrazol-3-yl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine	1621585-09-8	C₁₇H₁₇F₃N₄OS	382.409
——	N-[(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(5-fluoropyridin-2-yl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]benzamide	1621585-60-1	C₂₅H₂₀F₃N₃O₂S	483.514
——	N-[(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(6-methoxypyridin-3-yl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]benzamide	1621585-62-3</