1-O-phosphoryl-2,3-O-isopropylidene-D,L-glycerol | 65359-82-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-O-phosphoryl-2,3-O-isopropylidene-D,L-glycerol
• 英文别名: 2,3-O-isopropylideneglyceryl phosphate；1,2-O-Isopropylidenglycerin-3-phosphat；(+/-)-phosphoric acid mono-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester)；(+/-)-Phosphorsaeure-mono-(2,2-dimethyl-[1,3]dioxolan-4-ylmethylester)；(2,2-Dimethyl-1,3-dioxolan-4-yl)methyl dihydrogen phosphate
• CAS: 65359-82-2
• 化学式: C₆H₁₃O₆P
• 分子量: 212.139
• InChiKey: JUPNVAYKUHWAKQ-UHFFFAOYSA-N

物化性质

• 沸点：
  348.0±40.0 °C(Predicted)
• 密度：
  1.361±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  85.2
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  bis[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]-oxophosphanium 在 nitric oxide 、 水 作用下， 以 四氢呋喃 、 苯 为溶剂， 反应 7.0h， 生成 1-O-phosphoryl-2,3-O-isopropylidene-D,L-glycerol
  参考文献：
  名称：

  Nifant'ev, E. E.; Predvoditelev, D. A.; Fursenko, I. V., Journal of general chemistry of the USSR, 1981, p. 2098 - 2103

  摘要：

  DOI：

文献信息

• Salts of O-mono (di)-acetyl-glycero-mono-(bis)-(di)-phosphates of L-acetyl-carnitine and of L-acetyl carnitine esters
  申请人：MAGIS FARMACEUTICI S.p.A.

  公开号：EP0340759A1

  公开（公告）日：1989-11-08

  Salts of O-mono(di)-acetyl glycero-mono-(bis)-(di) phosphates of L-acetyl-carnitine and of L-acetyl carnitine ester are described. These acetyl derivatives are useful agent in the treatment of slow cerebral metabolism, senile and pre-senile psychomotor involution, depressive states, senile and pre-senile dementia and reduced cerebral blood flow caused by primitive cerebral ictus or cardiac affections.

  描述了O-单(二)-乙酰基甘油单-(双)-(二)磷酸盐的L-乙酰基肉碱和L-乙酰基肉碱酯。这些乙酰衍生物是治疗缓慢的脑代谢、老年和早老期心理运动退化、抑郁状态、老年和早老期痴呆症以及由原发性脑卒中或心脏疾病引起的脑血流减少的有效药剂。
• Cardiopathy-reducing phosphodiester lipids
  申请人：Signpath Pharma, Inc.

  公开号：US10975111B2

  公开（公告）日：2021-04-13

  The present invention includes compound having the following structural formula:

  本发明包括具有以下结构式的化合物：
• Autocleavage of<i>O</i>-Isopropylidene Protected<i>O</i>-Phosphono- and<i>O</i>- Thionophosphono Esters of Sugars
  作者：Denis Postel、Gino Ronco、Pierre Villa

  DOI：10.1080/07328300008544073

  日期：2000.1

  Phosphorylation of D-glucose, D-galactose, D-fructose, glycerol and xylitol acetals with diethoxy- or diphenoxy(thiono)phosphoryl chloride gave the corresponding esters. A novel method of partially and fully deprotecting these compounds, which we have called "autocatalytic cleavage", was effected by simply refluxing in water. Antifungal and insecticidal properties of these compounds are presented.
• Baddiley et al., Journal of the Chemical Society, 1958, p. 3107,3109
  作者：Baddiley et al.

  DOI：——

  日期：——
• NIFANTEV, EH. E.;PREDVODITELEV, D. A.;FURSENKO, I. V., ZH. OBSHCH. XIMII, 1981, 51, N 11, 2435-2441
  作者：NIFANTEV, EH. E.、PREDVODITELEV, D. A.、FURSENKO, I. V.

  DOI：——

  日期：——