N-(4-methoxyphenyl)-5-methoxyisatin | 186801-75-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-(4-methoxyphenyl)-5-methoxyisatin
• 英文别名: 5-methoxy-1-(4-methoxyphenyl)indole-2,3-dione
• CAS: 186801-75-2
• 化学式: C₁₆H₁₃NO₄
• 分子量: 283.284
• InChiKey: RBLSEGFCHVOJJU-UHFFFAOYSA-N

物化性质

• 沸点：
  485.2±55.0 °C(Predicted)
• 密度：
  1.318±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(4-methoxyphenyl)-5-methoxyisatin 在 氯化亚砜 、 potassium hydroxide 作用下， 生成 2,7-Dimethoxyacridine-9-carbonyl chloride
  参考文献：
  名称：

  甲氧羰基苯基-10-甲基10λ的化学发光4 -2,7-二取代的吖啶-9-羧酸酯衍生物

  摘要：

  甲氧羰基苯基-10-甲基10λ 4 -2,7-二取代的吖啶-9-羧酸酯衍生物的合成，并在pH 7-10既其化学发光的强度和它们的化学稳定性得到了澄清。评价了化学发光反应的产物和产生效率。4-（甲氧羰基）苯基-10-甲基10λ 4 -2,7- dimethylacridine -9-羧酸酯在pH 7-10，得到比较强的化学发光的强度和施加到过氧化氢的测量。

  DOI：

  10.1016/j.jphotochem.2020.112851
• 作为产物：
  描述：

  甲氧苯胺 在 AlCl₃ 盐酸 、 CuI 、 potassium carbonate 作用下， 以 二氯甲烷 、 二甲基亚砜 为溶剂， 生成 N-(4-methoxyphenyl)-5-methoxyisatin
  参考文献：
  名称：

  CHEMILUMINESCENT PROBES FOR MULTIPLEX MOLECULAR QUANTIFICATION AND USES THEREOF

  摘要：

  本文揭示了一种新的方法，用于同时检测和定量两个或更多核酸靶标，无需扩增。该方法依赖于独立杂交诱导化学发光信号（HICS）探针发出的化学发光的光谱-时间分辨率。通过在灵敏和同时独立定量多个细菌和真菌靶序列的均相分析中使用可分辨的N-连接丙二酰胺和2,7-二甲氧基丙二酰胺酯标记的探针，证明了该方法的实用性。还公开了用于实施本发明方法的组合物和试剂盒。

  公开号：

  US20120231459A1

文献信息

• Light-driven ion-pumping membrane systems
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US11318424B2

  公开（公告）日：2022-05-03

  Dye-sensitized ion-pumping membranes and methods of preparing said membranes are described herein. A regenerative and reversible photoactive dye is covalently-bonded to membrane or separator for ion-pumping. The photoactive dye-functionalized membranes can be arranged with other ion-exchange membranes, which serve as selective contacts to afford photovoltaic action and therefore form a power-producing membrane that pumps ions for use in driving an ion-exchange or ion-transport process, such as desalination and electrodialysis.

  本文描述了染料敏化离子泵膜和制备所述膜的方法。可再生和可逆的光敏染料与膜或分离器共价键合，用于离子泵。光敏染料功能化膜可与其他离子交换膜排列在一起，作为选择性接触以提供光生伏打作用，从而形成一种泵送离子的发电膜，用于驱动离子交换或离子传输过程，如海水淡化和电渗析。
• Simultaneous Quantification of Multiple Nucleic Acid Targets Using Chemiluminescent Probes
  作者：Kenneth A. Browne、Dimitri D. Deheyn、Gamal A. El-Hiti、Keith Smith、Ian Weeks

  DOI：10.1021/ja202221h

  日期：2011.9.21

  A novel method is described for simultaneous detection and quantification of attomoles or a few femtomoles of two (or potentially more) nucleic acid targets, without need for amplification. The technique depends on spectral-temporal resolution of chemiluminescence emitted from independent hybridization-induced chemiluminescent signal probes. The probes are internally quenched except in the presence of their specific targets, thereby allowing detection limits up to 10 000 times lower than with fluorescent probes. This is sufficient to obviate the need for amplification in many cases. The utility of the technique has been demonstrated by use of resolvable N-linked acridinium and 2,7-dimethoxy-acridinium ester labeled probes in a homogeneous assay for sensitive and simultaneous independent quantification of pan-bacterial and pan-fungal target sequences in seawater.
• Chemiluminescence of methoxycarbonylphenyl 10-methyl-10λ4 -2,7-disubstituted acridine-9-carboxylate derivatives
  作者：Manabu Nakazono、Shinkoh Nanbu、Takeyuki Akita、Kenji Hamase

  DOI：10.1016/j.jphotochem.2020.112851

  日期：2020.12

  7-disubstituted acridine-9-carboxylate derivatives were synthesized, and both their chemiluminescence intensities at pH 7−10 and their chemical stabilities were clarified. The products and generation efficiency of the chemiluminescence reactions were evaluated. 4-(Methoxycarbonyl)phenyl 10-methyl-10λ4-2,7-dimethylacridine-9-carboxylate gave relatively strong chemiluminescence intensities at pH 7−10 and was

  甲氧羰基苯基-10-甲基10λ 4 -2,7-二取代的吖啶-9-羧酸酯衍生物的合成，并在pH 7-10既其化学发光的强度和它们的化学稳定性得到了澄清。评价了化学发光反应的产物和产生效率。4-（甲氧羰基）苯基-10-甲基10λ 4 -2,7- dimethylacridine -9-羧酸酯在pH 7-10，得到比较强的化学发光的强度和施加到过氧化氢的测量。
• CHEMILUMINESCENT PROBES FOR MULTIPLEX MOLECULAR QUANTIFICATION AND USES THEREOF
  申请人：BROWNE Kenneth A.

  公开号：US20120231459A1

  公开（公告）日：2012-09-13

  A novel method is disclosed for simultaneous detection and quantification of two or more nucleic acid targets, without need for amplification. The method depends on spectral-temporal resolution of chemiluminescence emitted from independent hybridization-induced chemiluminescent signal (HICS) probes. The utility of this method has been demonstrated by use of resolvable N-linked acridinium and 2,7-dimethoxyacridinium ester labeled probes in a homogeneous assay for sensitive and simultaneous independent quantification of several bacterial and fungal target sequences. Compositions and kits for practicing the method of the present invention are also disclosed.

  本文揭示了一种新的方法，用于同时检测和定量两个或更多核酸靶标，无需扩增。该方法依赖于独立杂交诱导化学发光信号（HICS）探针发出的化学发光的光谱-时间分辨率。通过在灵敏和同时独立定量多个细菌和真菌靶序列的均相分析中使用可分辨的N-连接丙二酰胺和2,7-二甲氧基丙二酰胺酯标记的探针，证明了该方法的实用性。还公开了用于实施本发明方法的组合物和试剂盒。