N-dodecyl N-(dimethoxy-2,2) ethyl amine | 72816-70-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-dodecyl N-(dimethoxy-2,2) ethyl amine
• 英文别名: N-(2,2-dimethoxyethyl)dodecylamine；Dodecylaminocetaldehyd-dimethylacetal；N-(2,2-dimethoxyethyl)dodecan-1-amine
• CAS: 72816-70-7
• 化学式: C₁₆H₃₅NO₂
• 分子量: 273.459
• InChiKey: VBIMGJRKPAXZAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  19
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-dodecyl N-(dimethoxy-2,2) ethyl amine 、 硫氰酸 以20%的产率得到
  参考文献：
  名称：

  BAEUERLEIN E.; TRASCH H., LIEBIGS ANN. CHEM., 1979, NO 11, 1818-1827

  摘要：

  DOI：
• 作为产物：
  描述：

  十二烷基伯胺 、 2-氯乙醛缩二甲醇 生成 N-dodecyl N-(dimethoxy-2,2) ethyl amine
  参考文献：
  名称：

  Baeuerlein,E.; Trasch,H., Liebigs Annalen der Chemie, 1979, p. 1818 - 1827

  摘要：

  DOI：

文献信息

• Novel cyclic ureas as dermal penetration enhancers
  申请人：Merck & Co., Inc.

  公开号：EP0222664A2

  公开（公告）日：1987-05-20

  Certain novel cyclic ureas are disclosed herein as dermal penetration enhancers of drug absorption. Also disclosed herein are compositions, methods of treatment and processes for preparing said cyclic urea compounds.

  本文公开了某些新型环状脲类化合物，它们是促进药物吸收的皮肤渗透剂。 本文还公开了所述环状脲类化合物的组合物、治疗方法和制备工艺。
• Topical pharmaceutical composition to treat hyperpigmentation of the skin
  申请人：——

  公开号：US20030072724A1

  公开（公告）日：2003-04-17

  Provided is a topical pharmaceutical composition for skin lightening, which is particularly useful in treating skin hyperpigmentation, together with methods for its use. The composition and methods involve the topical use of an active agent effective in the treatment of skin hyperpigmentation plus a permeation-enhancing base that, in one embodiment, gives the composition a pH of about 8.0 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5.

  本发明提供了一种用于美白皮肤的外用药物组合物，该组合物尤其适用于治疗皮肤色素沉着，同时还提供了其使用方法。该组合物和方法涉及局部使用一种有效治疗皮肤色素沉着的活性剂和一种渗透增强基剂，在一个实施方案中，该基剂使组合物的 pH 值约为 8.0 至约 13.0，优选约为 8.0 至 11.5，最优选约为 8.5 至 10.5。
• Method and topical formulation for treating skin conditions associated with aging
  申请人：——

  公开号：US20030059450A1

  公开（公告）日：2003-03-27

  A composition and method are provided for alleviating the dermatological signs of intrinsic and extrinsic aging. A topical formulation containing a cosmeceutically active base, wherein the formulation has a pH in the range of about 7.5 to 13.0, is applied to the skin in order to prevent or treat aging-related skin conditions such as wrinkles, dry skin, age spots, sun damage (particularly UV radiation-induced oxidative stress), blemishes, hyperpigmented skin, age spots, increased skin thickness, loss of skin elasticity and collagen content, dry skin, lentigines and melasmas. The cosmeceutically active base is either a hydroxide-releasing agent, such as an inorganic hydroxide, an inorganic oxide, or a metal salt of a weak acid, or is an organic base, particularly a nitrogenous base.

  本发明提供了一种组合物和方法，用于减轻内在和外在衰老的皮肤病症状。将含有药用活性基的外用制剂（其中制剂的 pH 值在 7.5 至 13.0 之间）涂抹在皮肤上，以预防或治疗与衰老有关的皮肤病，如皱纹、皮肤干燥、老年斑、日光损伤（特别是紫外线辐射引起的氧化应激）、斑点、皮肤色素沉着、老年斑、皮肤厚度增加、皮肤弹性和胶原蛋白含量下降、皮肤干燥、色斑和黑斑。化妆品活性碱可以是氢氧化物释放剂，如无机氢氧化物、无机氧化物或弱酸的金属盐，也可以是有机碱，特别是含氮碱。
• Topical pharmaceutical composition for the treatment of warts
  申请人：——

  公开号：US20030072814A1

  公开（公告）日：2003-04-17

  Provided is a topical pharmaceutical composition for the treatment of warts, together with methods for its use. The composition and methods involve the topical use of an active agent effective in the treatment of warts plus a permeation-enhancing base that, in one embodiment, gives the composition a pH of about 8.0 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5. This composition can be used to treat human papilloma virus infections, particularly cutaneous warts.

  本发明提供了一种治疗尖锐湿疣的外用药物组合物及其使用方法。该组合物和方法涉及局部使用一种有效治疗尖锐湿疣的活性剂和一种渗透增强基质，在一个实施方案中，该基质使组合物的 pH 值约为 8.0 至约 13.0，优选约为 8.0 至 11.5，最优选约为 8.5 至 10.5。这种组合物可用于治疗人类乳头瘤病毒感染，特别是皮肤疣。
• Topical pharmaceutical composition for the treatment of inflammatory dermatoses
  申请人：——

  公开号：US20030077301A1

  公开（公告）日：2003-04-24

  Provided is a topical pharmaceutical composition for the treatment of inflammatory dermatoses, including acne vulgaris, together with methods for its use. The composition and methods involve the topical use of an active agent effective in the treatment of inflammatory dermatoses plus a permeation-enhancing base that, in one embodiment, gives the composition a pH of about 8.0 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5.

  本文提供了一种用于治疗炎症性皮肤病（包括寻常痤疮）的外用药物组合物及其使用方法。该组合物和方法涉及局部使用一种有效治疗炎症性皮肤病的活性剂和一种渗透增强基质，在一个实施方案中，该基质使组合物的 pH 值为约 8.0 至约 13.0，优选约 8.0 至 11.5，最优选约 8.5 至 10.5。