methyl (2E)-2-[(4-nitrophenyl)methylidene]-5-phenylpent-4-ynoate | 1072836-41-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: methyl (2E)-2-[(4-nitrophenyl)methylidene]-5-phenylpent-4-ynoate
• CAS: 1072836-41-9
• 化学式: C₁₉H₁₅NO₄
• 分子量: 321.332
• InChiKey: FVOSSPRDOJXFCY-SAPNQHFASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (碘乙炔基)苯 、 methyl 2-[acetoxy(4-nitrophenyl)methyl]acrylate 在 indium 、 indium(III) bromide 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 生成 methyl 2-methylene-3-(4-nitrophenyl)-5-phenylpent-4-ynoate 、 methyl (2E)-2-[(4-nitrophenyl)methylidene]-5-phenylpent-4-ynoate
  参考文献：
  名称：

  Indium-mediated alkynylation of Baylis–Hillman acetates: a novel route to 1,4-enynes

  摘要：

  Baylis-Hillman acetates undergo smooth alkynylation with aryl-susbstituted iodoalkynes in the presence of indium metal in refluxing dichloromethane to furnish 1,4-enynes in high yields with (E)-stereoselectivity. In the absence of Lewis acid, the reaction follows both S(N)2 and S(N)2' pathways affording 1:1 mixtures of 1,4-enynes. Upon addition of 10 mol % of InBr(3), the reaction proceeds preferably in the S(N)2' manner. In the case of adducts derived from acrylonitrile, the corresponding products are obtained in fairly good yields and with (Z)-stereoselectivity. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.08.019

文献信息

• Indium-mediated alkynylation of Baylis–Hillman acetates: a novel route to 1,4-enynes
  作者：Jhillu S. Yadav、Basi V. Subba Reddy、Nagendra Nath Yadav、Ashutosh Pratap Singh、Madavi Choudhary、Ajit C. Kunwar

  DOI：10.1016/j.tetlet.2008.08.019

  日期：2008.10

  Baylis-Hillman acetates undergo smooth alkynylation with aryl-susbstituted iodoalkynes in the presence of indium metal in refluxing dichloromethane to furnish 1,4-enynes in high yields with (E)-stereoselectivity. In the absence of Lewis acid, the reaction follows both S(N)2 and S(N)2' pathways affording 1:1 mixtures of 1,4-enynes. Upon addition of 10 mol % of InBr(3), the reaction proceeds preferably in the S(N)2' manner. In the case of adducts derived from acrylonitrile, the corresponding products are obtained in fairly good yields and with (Z)-stereoselectivity. (C) 2008 Elsevier Ltd. All rights reserved.