6-Methyl-1,2,3,4-tetrahydroquinoline-1-acetamide | 864463-33-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 6-Methyl-1,2,3,4-tetrahydroquinoline-1-acetamide
• 英文别名: 2-(6-methyl-3,4-dihydro-2H-quinolin-1-yl)acetamide
• CAS: 864463-33-2
• 化学式: C₁₂H₁₆N₂O
• mdl: MFCD07073211
• 分子量: 204.272
• InChiKey: MCNPBTSTTXHPDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-Methyl-1,2,3,4-tetrahydroquinoline-1-acetamide 在 甲烷磺酸 、 potassium tert-butylate 、 三氟乙酸 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 9-methyl-6,7,11,15b-tetrahydro-5H-indolo[2',3':4,5]pyrrolo[3',4':6,7]azepino[3,2,1-ij]quinoline-1,3(2H,10bH)-dione
  参考文献：
  名称：

  Synthesis of 4-substituted 3-(indol-3-yl)maleimides and azepines with annelated indole and maleimide nuclei

  摘要：

  A series of 4-substituted 3-(indole-3-yl)maleimides has been synthesized. Upon the action of CH3SO3H in TFA, the 3-(indole-3-yl)-4-(arylalkylamino)-maleimides undergo cyclization to give 12b,13-dihydro-4bH-indolo[3,2-d]pyrrolo[3,4-b][1]benzazepine-5,7(6H, 8H)-dione derivatives. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.06.027
• 作为产物：
  描述：

  6-甲基-1,2,3,4-四氢喹啉 、 氯乙酰胺 在 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以80%的产率得到6-Methyl-1,2,3,4-tetrahydroquinoline-1-acetamide
  参考文献：
  名称：

  Synthesis of 4-substituted 3-(indol-3-yl)maleimides and azepines with annelated indole and maleimide nuclei

  摘要：

  A series of 4-substituted 3-(indole-3-yl)maleimides has been synthesized. Upon the action of CH3SO3H in TFA, the 3-(indole-3-yl)-4-(arylalkylamino)-maleimides undergo cyclization to give 12b,13-dihydro-4bH-indolo[3,2-d]pyrrolo[3,4-b][1]benzazepine-5,7(6H, 8H)-dione derivatives. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.06.027

文献信息

• Heterocyclic derivatives as modulators of ion channels
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：EP2316829A1

  公开（公告）日：2011-05-04

  The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

  本发明涉及可用作离子通道抑制剂的杂环衍生物。本发明还提供了包含本发明化合物的药学上可接受的组合物，以及使用该组合物治疗各种疾病的方法。
• [EN] HETEROCYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS<br/>[FR] DERIVES HETEROCYCLIQUES UTILISES COMME MODULATEURS DE CANAUX IONIQUES
  申请人：VERTEX PHARMA

  公开号：WO2007075895A2

  公开（公告）日：2007-07-05

  [EN] The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
  [FR] La présente invention concerne des dérivés hétérocycliques servant d'inhibiteurs de canaux ioniques. Cette invention concerne aussi des compositions pharmaceutiquement acceptables qui contiennent les composés de la présente invention ainsi que des méthodes d'utilisation de ces compositions pour le traitement de plusieurs troubles.
• Synthesis of 4-substituted 3-(indol-3-yl)maleimides and azepines with annelated indole and maleimide nuclei
  作者：Sergey A. Lakatosh、Yuri N. Luzikov、Maria N. Preobrazhenskaya

  DOI：10.1016/j.tet.2005.06.027

  日期：2005.8

  A series of 4-substituted 3-(indole-3-yl)maleimides has been synthesized. Upon the action of CH3SO3H in TFA, the 3-(indole-3-yl)-4-(arylalkylamino)-maleimides undergo cyclization to give 12b,13-dihydro-4bH-indolo[3,2-d]pyrrolo[3,4-b][1]benzazepine-5,7(6H, 8H)-dione derivatives. (c) 2005 Elsevier Ltd. All rights reserved.