4-(4-chloro-3-fluorophenoxy)-N-methylthieno[2,3-c]pyridine-2-carboxamide | 251994-17-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(4-chloro-3-fluorophenoxy)-N-methylthieno[2,3-c]pyridine-2-carboxamide
• CAS: 251994-17-9
• 化学式: C₁₅H₁₀ClFN₂O₂S
• 分子量: 336.774
• InChiKey: JOMCAHFBIFZMLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  79.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] TETRAHYDROBENZAZEPINE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE D3 RECEPTORS (ANTIPSYCHOTIC AGENTS)<br/>[FR] DERIVES DE TETRAHYDROBENZOZEPINE UTILES COMME MODULATEURS DES RECEPTEURS DE LA LA DOPAMINE D3
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2000021951A1

  公开（公告）日：2000-04-20

  Compounds of formula (I), wherein R2 represents a hydrogen atom or a C¿1-4?alkyl group; q is 1 or 2; A represents a group of formula (a), (b), (c) or (d), wherein Ar represents an optionally substituted phenyl ring or an optionally substituted 5- or 6-membered aromatic heterocyclic ring; or an optionally substituted bicyclic ring system; Ar?1 and Ar2¿ each independently represent an optionally substituted phenyl ring or an optionally substituted 5- or 6-membered aromatic heterocyclic ring; and Y represents a bond, -NHCO-, -CONH-, -CH¿2?-, or -(CH2)mY?1(CH¿2)n-, wherein Y1 represents O, S, SO¿2?, or CO and m and n each represent zero or 1 such that the sum of m+n is zero or 1; providing that when A represents a group of formula (a), any substituent present in Ar ortho to the carboxamide moiety is necessarily a hydrogen or a methoxy group; r and s independently represent an integer from zero to 3 such that the sum of r and s is equal to an integer from 1 to 4; V represents a bond, O or S; and salts thereof. Compounds of formula (I) and their salts have affinity for dopamine receptors, in particular the D3 receptor, and thus potential in the treatment of conditions wherein modulation of the D3 receptor is beneficial, e.g. as antipsychotic agents.

  式(I)的化合物，其中R2代表氢原子或C1-4烷基；q为1或2；A代表式(a)、(b)、(c)或(d)的基团，其中Ar代表可选取代的苯环或可选取代的5-或6-成员芳香杂环环；或可选取代的双环系统；Ar1和Ar2各自独立地代表可选取代的苯环或可选取代的5-或6-成员芳香杂环环；而Y代表键，-NHCO-，-CONH-，-CH2-或-(CH2)mY1(CH2)n-，其中Y1代表O、S、SO2或CO，而m和n各自代表零或1，使得m+n的和为零或1；但是当A代表式(a)的基团时，任何位于羧酰胺基团正交的取代基必须是氢或甲氧基；r和s各自独立地代表从零到3的整数，使得r和s的和等于从1到4的整数；V代表键，O或S；以及其盐。式(I)的化合物及其盐具有亲和力，特别是对D3受体，因此在调节D3受体有益的情况下，具有潜在的治疗作用，例如作为抗精神病药物。
• Cell adhesion-inhibiting antiinflammatory compounds
  申请人：——

  公开号：US20010020030A1

  公开（公告）日：2001-09-06

  Compounds having Formula I 1 are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of inhibiting/treating inflammatory diseases in a mammal.

  具有I1式的化合物对于治疗炎症有用。本文还公开了包含I式化合物的制药组合物，以及在哺乳动物中抑制/治疗炎症性疾病的方法。
• CELL ADHESION-INHIBITING ANTINFLAMMATORY COMPOUNDS
  申请人：ABBOTT LABORATORIES

  公开号：EP1090009A2

  公开（公告）日：2001-04-11
• TETRAHYDROBENZAZEPINE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE D3 RECEPTORS (ANTIPSYCHOTIC AGENTS)
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP1119563A1

  公开（公告）日：2001-08-01
• CELL ADHESION-INHIBITING ANTIINFLAMMATORY COMPOUNDS
  申请人：ABBOTT LABORATORIES

  公开号：EP1181296A1

  公开（公告）日：2002-02-27