O-ethyl (2'-oxospiro[1,3-dioxolane-2,3'-indole]-1'-yl)methylsulfanylmethanethioate | 1167424-33-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: O-ethyl (2'-oxospiro[1,3-dioxolane-2,3'-indole]-1'-yl)methylsulfanylmethanethioate
• CAS: 1167424-33-0
• 化学式: C₁₄H₁₅NO₄S₂
• 分子量: 325.409
• InChiKey: RWWRTOPFJYXDJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  105
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  O-ethyl (2'-oxospiro[1,3-dioxolane-2,3'-indole]-1'-yl)methylsulfanylmethanethioate 、 烯丙基腈 在 过氧化双月桂酰 作用下， 以 乙酸乙酯 为溶剂， 以65%的产率得到O-ethyl [1-cyano-4-(2'-oxospiro[1,3-dioxolane-2,3'-indole]-1'-yl)butan-2-yl]sulfanylmethanethioate
  参考文献：
  名称：

  Radical Arylaminomethylation of Unactivated Alkenes

  摘要：

  Xanthates derived from open chain or cyclic N-chloromethylanilides are capable of adding to various unactivated alkenes to give adducts which, in suitable cases, can be made to undergo ring closure onto the aromatic ring. This flexible arylaminomethylation of alkenes allows the rapid synthesis of open chain or polycyclic aniline derivatives.

  DOI：

  10.1021/ol901055j
• 作为产物：
  描述：

  螺[1,3-二氧戊环-2,3'-[3H]吲哚]-2'(1'H)-酮 、 聚合甲醛 、 potassium ethyl xanthogenate 在 三甲基氯硅烷 作用下， 以 乙腈 、 丙酮 为溶剂， 反应 16.67h， 以98%的产率得到O-ethyl (2'-oxospiro[1,3-dioxolane-2,3'-indole]-1'-yl)methylsulfanylmethanethioate
  参考文献：
  名称：

  Radical Arylaminomethylation of Unactivated Alkenes

  摘要：

  Xanthates derived from open chain or cyclic N-chloromethylanilides are capable of adding to various unactivated alkenes to give adducts which, in suitable cases, can be made to undergo ring closure onto the aromatic ring. This flexible arylaminomethylation of alkenes allows the rapid synthesis of open chain or polycyclic aniline derivatives.

  DOI：

  10.1021/ol901055j

文献信息

• Radical Arylaminomethylation of Unactivated Alkenes
  作者：Frédéric Lebreux、Béatrice Quiclet-Sire、Samir Z. Zard

  DOI：10.1021/ol901055j

  日期：2009.7.2

  Xanthates derived from open chain or cyclic N-chloromethylanilides are capable of adding to various unactivated alkenes to give adducts which, in suitable cases, can be made to undergo ring closure onto the aromatic ring. This flexible arylaminomethylation of alkenes allows the rapid synthesis of open chain or polycyclic aniline derivatives.