N-Butyl-N-methyl-acetamid | 10601-67-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Butyl-N-methyl-acetamid
• 英文别名: N-butyl-N-methylacetamide；N-Methyl-N-butylacetamid；N-butyl-N-methyl-acetamide
• CAS: 10601-67-9
• 化学式: C₇H₁₅NO
• mdl: MFCD20356378
• 分子量: 129.202
• InChiKey: MBRADLLFMJDSSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  三氟溴甲烷 、 N-Butyl-N-methyl-acetamid 在 三氯化硼 、 六乙基亚磷酸胺 作用下， 以25%的产率得到2-(n-butylmethylamino)-1,1,1-trifluoro-propene
  参考文献：
  名称：

  A simple one-pot synthesis of α-trifluoromethyl-substituted enamines by C-trifluoromethylation of dialkylamides with

  摘要：

  Dialkylamides of the general formula R(3)R(2)NC(O)CH(2)R(1), and Me-N-C(O)-CH2-(CH2)(n)-CH2, n=1-3, react with the reagent combination P(NEt(2))(3)/CF3Br in the presence of BCl3 to give alpha-trifluoromethyl enamines R(3)R(2)N-C(CF3)=CHR(1), R(1)=H, R(2)=R(3)=Me (I), Et(II), Pr-i(III); R(2)=(n)Bu, R(3)=Me(IV); R(1)=R(2)=R(3)=Me(Va/b); Me-N-C(CF3)=CH-(CH2)(n)-CH2, n=1 (VI), 2 (VII) and 3 (VIII) in yields of 25%-36%. Hydrolysis of VI by hydrochloric acid yielded the salt [Me-NH-C(CF3)(OH)-CH2-CH2-CH2]Cl-+(-) (IX), the deprotonation of which with NaOH gave the 2-hydroxypyrrolidine Me-N-C(CF3)(OH)-CH2-CH2-CH2 (X). The novel compounds have been characterized by elemental analyses, multinuclear NMR, IR and mass spectroscopy.

  DOI：

  10.1016/0022-1139(94)03090-m
• 作为产物：
  描述：

  甲基丁胺 在 对甲苯磺酸 、 APTS 作用下， 反应 0.41h， 生成 N-Butyl-N-methyl-acetamid
  参考文献：
  名称：

  Synthesis in dry media coupled with microwave irradiation : Application to the preparation of enaminoketones.

  摘要：

  Beta-diketones react with a variety of amines and aminoesters over clay K10 or silica under microwave irradiation in open vessels to give within a few minutes, the corresponding enaminoketones with good yields. According to the reaction conditions acylamines may also result.

  DOI：

  10.1016/s0040-4039(00)60678-0

文献信息

• [EN] PRMT5 INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE PRMT5 ET LEURS UTILISATIONS
  申请人：EPIZYME INC

  公开号：WO2014100695A1

  公开（公告）日：2014-06-26

  Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.

  本文描述了式（A）的化合物，其药学上可接受的盐以及药物组合物。本发明的化合物对抑制PRMT5活性是有用的。还描述了利用这些化合物治疗PRMT5介导的疾病的方法。
• ATPENINS
  申请人：ADELT Isabelle

  公开号：US20100168175A1

  公开（公告）日：2010-07-01

  The present invention relates to processes for preparing certain 2-pyridones and 2-pyridinols, to novel compounds of these two types and to their use as biologically active compounds, in particular for controlling harmful microorganisms in crop protection, in the medicinal field and in the protection of materials.

  本发明涉及制备特定2-吡啶酮和2-吡啶醇的过程，涉及这两种类型的新化合物以及它们作为生物活性化合物的用途，特别是用于控制农作物保护中的有害微生物，在医药领域和材料保护中。
• Microwave-assisted preparation of amides using a stable and reusable mesoporous carbonaceous solid acid
  作者：Rafael Luque、Vitaly Budarin、James H. Clark、Duncan J. Macquarrie

  DOI：10.1039/b821392p

  日期：——

  An efficient and green microwave assisted protocol to prepare amides from amines via N-acylation using acidic polysaccharide derived mesoporous materials provides quantitative yields of amides in short reaction times.

  一种高效、绿色的微波辅助合成方法：利用酸性多糖衍生介孔材料通过N-酰化反应从胺制备酰胺，能在短时间内实现酰胺的定量产率。
• Copper-Catalyzed <i>N</i>-Methylation of Amides and <i>O</i>-Methylation of Carboxylic Acids by Using Peroxides as the Methylating Reagents
  作者：Qinqin Xia、Xiaolong Liu、Yuejiao Zhang、Chao Chen、Wanzhi Chen

  DOI：10.1021/ol401362k

  日期：2013.7.5

  The copper-catalyzed N-methylation of amides and O-methylation of carboxylic acids by using peroxides as the methylating reagent are described. Various amides and carboxylic acids were methylated affording N-substituted amides and esters. Tentative mechanistic studies suggest that this reaction is likely to involve a radical process.

  描述了通过使用过氧化物作为甲基化试剂的铜催化的酰胺的N-甲基化和羧酸的O-甲基化。使各种酰胺和羧酸甲基化，得到N-取代的酰胺和酯。初步的机理研究表明，该反应可能涉及一个激进过程。
• PRODRUGS OF NH-ACIDIC COMPOUNDS: ESTER, CARBONATE, CARBAMATE AND PHOSPHONATE DERIVATIVES
  申请人：Blumberg Laura Cook

  公开号：US20110319422A1

  公开（公告）日：2011-12-29

  The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.

  该发明提供了一种持续释放内酰胺、亚酰胺、酰胺、磺胺、碳酸酯或尿素含有母药的方法，通过向患者施用该发明的一种前药化合物的有效量，在向患者施用后，从前药中释放母药是持续释放的。适用于该发明方法的前药化合物是母药的不稳定结合物，通过羰基连接的前药基团进行衍生化。该发明的前药化合物可用于治疗任何需要内酰胺、亚酰胺、酰胺、磺胺、碳酸酯或尿素含有母药作为治疗的情况。