1-Phenyl-2-bromododecanone | 63424-83-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Phenyl-2-bromododecanone
• 英文别名: 2-bromo-1-phenyldodecan-1-one；2-Brom-1-phenyl-dodecan-1-on；2-Bromo-1-phenyldodecan-1-one
• CAS: 63424-83-9
• 化学式: C₁₈H₂₇BrO
• 分子量: 339.316
• InChiKey: ZURTVYXXSRAADP-UHFFFAOYSA-N

物化性质

• 熔点：
  29-30 °C
• 沸点：
  391.9±15.0 °C(Predicted)
• 密度：
  1.132±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  20
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-Phenyl-2-bromododecanone 在 乙醚 、 aluminum isopropoxide 、 异丙醇 作用下， 生成 1-phenyl-2-piperidino-dodecan-1-ol; hydrochloride
  参考文献：
  名称：

  ANTIMALARIALS. α-PHENYL-β-DIALKYLAMINO ALCOHOLS¹

  摘要：

  DOI：

  10.1021/jo01169a001
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 四氯化碳 、 溴 作用下， 生成 1-Phenyl-2-bromododecanone
  参考文献：
  名称：

  ANTIMALARIALS. α-PHENYL-β-DIALKYLAMINO ALCOHOLS¹

  摘要：

  DOI：

  10.1021/jo01169a001

文献信息

• Chiral Phosphoric Acid Catalyzed Enantioselective Synthesis of α-Tertiary Amino Ketones from Sulfonium Ylides
  作者：Wengang Guo、Yuzheng Luo、Herman H.-Y. Sung、Ian D. Williams、Pingfan Li、Jianwei Sun

  DOI：10.1021/jacs.0c07210

  日期：2020.8.19

  approach for the synthesis of chiral α-amino ketones, which is particularly useful for the less accessible acyclic α-tertiary cases. By a protonation-amination sequence, our approach represents a rare asymmetric H-heteroatom bond insertion by α-carbonyl sulfonium ylides, an attractive surrogate of diazocarbonyls. The mild intermolecular C-N bond formation was catalyzed by chiral phosphoric acids with excellent

  在此，我们公开了一种用于合成手性 α-氨基酮的新的催化不对称方法，该方法对于不太容易获得的无环 α-三级情况特别有用。通过质子化-胺化序列，我们的方法代表了 α-羰基锍叶立德（一种有吸引力的重氮羰基替代物）插入罕见的不对称 H-杂原子键。温和的分子间 CN 键形成由手性磷酸催化，具有优异的效率和对映选择性。这些产品是其他重要手性胺衍生物的前体，包括药物分子和手性配体。对映选择性由胺化步骤中的动态动力学拆分控制，而不是初始质子化。这一过程为其他相关插入反应的发展开辟了一个新平台。
• Nanosize Lipophilic Polyacrylate Particles and Their Photoinduced Flocculation in Hydrocarbon Solvents
  作者：Zhaoqing Liu、Mitchell A. Winnik、Tze-Chi Jao、Joachim Rösch

  DOI：10.1021/jp972540x

  日期：1998.7.1

  The synthesis, characterization, and proper,ies of colloidal nanostructures in hydrocarbon media are reported. These sterically stabilized structures are unusual in that the stabilizing arms are attached to the particle by photoactive groups, and the arms can be cleaved through irradiation, leading to photoinduced flocculation. In the first step of the synthesis, cross-linked poly(butyl methacrylate) (PBMA) latex particles with controlled functionality (-COOH and -OH groups) were prepared by emulsion polymerization. The purified PBMA latex was neutralized with Cs2CO3 and then transferred to an organic medium (dimethylformamide), where it was converted to lipophilic nanoparticles through chemical modification with 2-bromo derivatives of long-chain 1-phenylalkyl ketones or nitrobenzyl ether derivatives of polyisobutylene, The particles can be dispersed in hydrocarbon solvents. Irradiation leads to flocculation, except that in the presence of hydrocarbon-soluble polymers bearing amino groups, the unprotected particles can be intercepted and flocculation inhibited. These particles serve as an interesting model for precursors to sludge formation in motor oil.
• ANTIMALARIALS. α-PHENYL-β-DIALKYLAMINO ALCOHOLS¹
  作者：ROBERT E. LUTZ、RUFUS K. ALLISON、GILBERT ASHBURN、PHILIP S. BAILEY、MARION T. CLARK、JOHN F. CODINGTON、ADOLF J. DEINET、JAMES A. FREEK、ROBERT H. JORDAN、NORMAN H. LEAKE、TELLIS A. MARTIN、KENT C. NICODEMUS、RUSSELL J. ROWLETT、NEWTON H. SHEARER、J. DOYLE SMITH、JAMES W. WILSON

  DOI：10.1021/jo01169a001

  日期：1947.9