3-(hydroxymethylene)-1,3-dihydro-2H-indol-2-one | 265107-68-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(hydroxymethylene)-1,3-dihydro-2H-indol-2-one
• 英文别名: 3-(Hydroxymethylene)indol-2-one；3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one；(3Z)-3-(hydroxymethylene)-1,3-dihydro-2H-indol-2-one；Z 3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one；3-Hydroxymethylene-1,3-dihydro-indol-2-one；3-hydroxymethylene-1,3-dihydroindol-2-one；(3Z)-3-(hydroxymethylidene)-1H-indol-2-one
• CAS: 265107-68-4
• 化学式: C₉H₇NO₂
• 分子量: 161.16
• InChiKey: ZRKPUQFDPAIVPD-ALCCZGGFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.54
• 重原子数：
  12.0
• 可旋转键数：
  0.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.33
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  3-(hydroxymethylene)-1,3-dihydro-2H-indol-2-one 在 氯化亚砜 作用下， 以92%的产率得到(Z)-3-chloromethylene-indolin-2-one
  参考文献：
  名称：

  Wasalexins A和B，来自芥末的新植物抗毒素：分离，合成和抗真菌活性。

  摘要：

  芥蓝（Wasabia japonica，同种Eutrema wasabi）中两种植物抗毒素的化学结构测定，芥蓝对黑腿真菌[Leptosphaeria maculans（Desm。）Ces。等人，无性阶段Phoma lingam（Tode ex Fr.）Desm。]，以及它们的合成和对P. lingam和山葵假单胞菌的分离物的抗真菌活性已有报道。

  DOI：

  10.1016/s0960-894x(99)00523-5
• 作为产物：
  描述：

  trans-3-(dimethylaminomethylene)oxindole 以51%的产率得到
  参考文献：
  名称：

  Isakowitsch I. P., Asimow W. A., Rjabowa S. Ju., Alekseewa L. M., Parshin+, Khim.-farmach. zh, 29 (1995) N 2, S 22-26, 64

  摘要：

  DOI：

文献信息

• Substituted oxindole derivatives as tyrosine kinase inhibitors
  申请人：——

  公开号：US20030195234A1

  公开（公告）日：2003-10-16

  The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis, In particular, the present invention relates to a series of substituted oxindole compounds, which exhihit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.

  本发明涉及结构（I）的氧吲哚衍生物，含有该衍生物的组合物，以及使用和制造该衍生物的方法。这类化合物通常在通过改变通常是通过改变丝裂原活化信号通路而缓解的疾病状态中具有药理学作用，特别是在抑制或拮抗蛋白激酶，这些病理上涉及异常细胞增殖的情况中。这些疾病状态包括肿瘤生长、再狭窄、动脉粥样硬化、疼痛和血栓形成。特别是，本发明涉及一系列取代氧吲哚化合物，这些化合物表现出Trk家族蛋白酪氨酸激酶抑制作用，并在癌症治疗和慢性疼痛指示中有用。
• Kinase Inhibitors
  申请人：Wurster A. Julie

  公开号：US20070032478A1

  公开（公告）日：2007-02-08

  The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

  本发明涉及有机分子，能够调节酪氨酸激酶信号传导，以调节、调控和/或抑制异常细胞增殖。
• Substituted oxidole derivatives as protein tyrosine and as protein serine/threonine kinase inhibitors
  申请人：SmithKline Beecham Corporation

  公开号：US06369086B1

  公开（公告）日：2002-04-09

  The present invention relates generally to novel substituted oxindole compounds and compositions. Such compounds and compositions have utility as pharmacological agents in treating diseases or conditions alleviated by the inhibition or antagonism of protein kinase activated signalling pathways. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit protein tyrosine kinase and protein serine/threonine kinase inhibition, and which are useful in inhibiting tumor growth via inhibition of such kinases as well as protecting a patient undergoing chemotherapy from chemotherapy induced alopecia.

  本发明总体上涉及新颖的取代吲哚化合物和组合物。这类化合物和组合物作为治疗药物，在治疗通过抑制或拮抗蛋白激酶激活的信号通路而缓解的疾病或状况方面具有效用。特别是，本发明涉及一系列取代吲哚化合物，这些化合物表现出蛋白酪氨酸激酶和蛋白丝氨酸/苏氨酸激酶的抑制作用，并且可用于通过抑制这些激酶来抑制肿瘤生长，以及保护接受化疗的患者免受化疗引起的脱发。
• Kinase inhibitors for the treatment of disease
  申请人：Allergan, Inc.

  公开号：US06699863B1

  公开（公告）日：2004-03-02

  The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

  本发明涉及有机分子，能够调节酪氨酸激酶信号传导，以调控、调节和/或抑制异常细胞增殖。
• KINASE INHIBITORS FOR THE TREATMENT OF DISEASE
  申请人：Allergan, Inc.

  公开号：US20040102509A1

  公开（公告）日：2004-05-27

  The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

  本发明涉及有机分子，能够调节酪氨酸激酶信号传导，以调控、调节和/或抑制异常细胞增殖。