1-(4-Hydroxyphenyl)-2-[(4-methylphenyl)sulfonyl]ethanone | 896109-71-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-Hydroxyphenyl)-2-[(4-methylphenyl)sulfonyl]ethanone
• 英文别名: 1-(4-hydroxyphenyl)-2-(4-methylphenyl)sulfonylethanone
• CAS: 896109-71-0
• 化学式: C₁₅H₁₄O₄S
• 分子量: 290.34
• InChiKey: WOZVZBJZOIRWGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  79.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(4-Hydroxyphenyl)-2-[(4-methylphenyl)sulfonyl]ethanone 在 ammonium cerium (IV) nitrate 、 氧气 作用下， 以 乙腈 为溶剂， 反应 4.0h， 以90%的产率得到对羟基苯甲酸
  参考文献：
  名称：

  Oxidative cleavage of α-sulfonyl ketones to carboxylic acids with Ce(NH4)2(NO3)6

  摘要：

  Tandem oxidative cleavage of alpha-sulfonyl arylketones 2 with the combination of Ce(NH4)(2)(NO3)(6) and O-2 in MeCN afforded carboxylic acids 3 in moderate to good yields. The plausible reaction mechanism has been discussed. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.08.038
• 作为产物：
  描述：

  2-溴-4'-羟基苯乙酮 、 sodium 4-methylbenzenesulfinate 在 PEG-400 作用下， 反应 0.17h， 以93%的产率得到1-(4-Hydroxyphenyl)-2-[(4-methylphenyl)sulfonyl]ethanone
  参考文献：
  名称：

  Facile polyethylene glycol (PEG-400) promoted synthesis of β-ketosulfones

  摘要：

  An efficient and convenient synthesis of beta-ketosulfones is described. Reaction of an alpha-haloketone with sodium alkyl/aryl sulphinate yields the corresponding beta-ketosulfone promoted by polyethylene glycol (PEG-400) as an efficient reaction medium. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.03.181

文献信息

• Synthesis of α-iodo β-ketosulfones and α-iodo methylsulfones using iodine monochloride
  作者：N. Suryakiran、T. Srikanth Reddy、V. Suresh、M. Lakshman、Y. Venkateswarlu

  DOI：10.1016/j.tetlet.2006.04.123

  日期：2006.6

  The synthesis of α-iodo β-ketosulfones and α-iodo methylsulfones is described. Reaction of β-ketosulfones with iodine monochloride in acetic acid at room temperature gave the corresponding α-iodo β-ketosulfones, which, on treatment with aqueous alkali, underwent base-induced cleavage to afford α-iodo methylsulfones.

  描述了α-碘β-酮砜和α-碘甲基砜的合成。β-酮砜与一氯化碘在乙酸中于室温下反应，得到相应的α-碘β-酮砜，将其用碱水溶液处理，进行碱诱导的裂解，得到α-碘甲基甲砜。
• Oxidative cleavage of α-sulfonyl ketones to carboxylic acids with Ce(NH4)2(NO3)6
  作者：Meng-Yang Chang、Chung-Yu Tsai

  DOI：10.1016/j.tetlet.2014.08.038

  日期：2014.10

  Tandem oxidative cleavage of alpha-sulfonyl arylketones 2 with the combination of Ce(NH4)(2)(NO3)(6) and O-2 in MeCN afforded carboxylic acids 3 in moderate to good yields. The plausible reaction mechanism has been discussed. (C) 2014 Elsevier Ltd. All rights reserved.
• Facile polyethylene glycol (PEG-400) promoted synthesis of β-ketosulfones
  作者：N. Suryakiran、T. Srikanth Reddy、K. Ashalatha、M. Lakshman、Y. Venkateswarlu

  DOI：10.1016/j.tetlet.2006.03.181

  日期：2006.6

  An efficient and convenient synthesis of beta-ketosulfones is described. Reaction of an alpha-haloketone with sodium alkyl/aryl sulphinate yields the corresponding beta-ketosulfone promoted by polyethylene glycol (PEG-400) as an efficient reaction medium. (c) 2006 Elsevier Ltd. All rights reserved.