4-(5-methyl-benzooxazol-2-yl)-phenol | 59428-13-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(5-methyl-benzooxazol-2-yl)-phenol
• 英文别名: 4-(5-Methyl-1,3-benzoxazol-2-yl)phenol
• CAS: 59428-13-6
• 化学式: C₁₄H₁₁NO₂
• 分子量: 225.247
• InChiKey: AJGLTOHCHWCJRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(5-methyl-benzooxazol-2-yl)-phenol 在 potassium carbonate 、 potassium iodide 作用下， 以 丙酮 、 乙腈 为溶剂， 生成 3-(1-(3-(4-(5-methylbenzo[d]oxazol-2-yl)phenoxy)propyl)piperidin-4-yl)-6-fluoro-benzo[d]isoxazole
  参考文献：
  名称：

  Synthesis and pharmacological evaluation of piperidine (piperazine)-substituted benzoxazole derivatives as multi-target antipsychotics

  摘要：

  The present study describes the optimization of a series of novel benzoxazole-piperidine (piperazine) derivatives combining high dopamine D-2 and serotonin 5-HT1A, 5-HT2A receptor affinities. Of these derivatives, the pharmacological features of compound 29 exhibited high affinities for the DA D-2, 5-HT1A and 5-HT2A receptors, but low affinities for the 5-HT2C and histamine H-1 receptors and human ether-a-go-go-related gene (hERG) channels. Furthermore, compound 29 reduced apomorphine-induced climbing and 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced head twitching without observable catalepsy, even at the highest dose tested. Thus, compound 29 is a promising candidate as a multi-target antipsychotic treatment. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.09.045
• 作为产物：
  描述：

  5-甲基苯并唑 、 对羟基苯甲醛 在 乙二醇 、 zinc(II) chloride 作用下， 以 neat (no solvent) 为溶剂， 反应 6.5h， 以70%的产率得到4-(5-methyl-benzooxazol-2-yl)-phenol
  参考文献：
  名称：

  苯并恶唑与芳香醛的深度共晶溶剂催化芳基化†

  摘要：

  开发了一种由深共熔溶剂催化苯并恶唑与芳香醛芳基化的新型有效方法。该反应在各种底物上顺利进行，在很短的反应时间内以高产率得到所需的产物。低共熔溶剂很容易回收和重复使用，而不会显着损失催化活性。

  DOI：

  10.1039/c8ra01094c

文献信息

• Phosphonium acidic ionic liquid: an efficient and recyclable homogeneous catalyst for the synthesis of 2-arylbenzoxazoles, 2-arylbenzimidazoles, and 2-arylbenzothiazoles
  作者：Quang The Nguyen、Anh-Hung Thi Hang、Thuy-Linh Ho Nguyen、Duy-Khiem Nguyen Chau、Phuong Hoang Tran

  DOI：10.1039/c8ra01709c

  日期：——

  A highly efficient and green strategy for the synthesis of 2-arylbenzoxazoles, 2-arylbenzimidazoles, and 2-arylbenzothiazoles catalyzed by phosphonium acidic ionic liquid has been developed via the condensation of o-aminophenol, o-phenylenediamines, and o-aminothiophenol, respectively, with aldehydes. The reaction has a good yield, the broad substrate scope, and mild condition. Triphenyl(butyl-3-s

  分别通过邻氨基苯酚、邻苯二胺和邻氨基苯硫酚的缩合，开发了一种由鏻酸性离子液体催化合成 2-芳基苯并恶唑、2-芳基苯并咪唑和 2-芳基苯并噻唑的高效绿色策略，与醛。该反应收率好，底物范围广，条件温和。三苯基(丁基-3-磺酰基)鏻甲苯磺酸盐催化剂通过一锅法合成很容易从廉价且可用的起始材料中获得。其结构经1 H NMR、13 C NMR、31P NMR和FT-IR技术。热稳定性和酸度等其他性质采用TGA和Hammett酸度函数法测定。有趣的是，催化剂在第四次复苏之前仍能保持其持续的出色表现。
• Chromophore Coated Metal Oxide Particles
  申请人：Schehlmann Volker

  公开号：US20090291107A1

  公开（公告）日：2009-11-26

  The invention provides coated metal oxide particles, wherein metal oxide particles are coated with at least one type of crosslinkable chromophore with UV-A and/or UV-B and/or UV-C filter and/or broadband activity and optionally at least one type of crosslinkable monomer which does not have UV-A and/or UV-B and/or UV-C and/or broadband filter activity and process to obtain coated metal oxide particles and their use especially in cosmetic or dermatological formulations for the protection against harmful effects of sunlight.

  该发明提供了一种涂覆金属氧化物颗粒的方法，其中金属氧化物颗粒被至少一种具有UV-A和/或UV-B和/或UV-C和/或宽带活性的可交联色团涂覆，并且可选择涂覆至少一种不具有UV-A和/或UV-B和/或UV-C和/或宽带过滤活性的可交联单体，以及获得涂覆金属氧化物颗粒的过程和它们在化妆品或皮肤科配方中的使用，以保护皮肤免受阳光的有害影响。
• Microcapsules with uv filter activity and process for producing them
  申请人：Berg-Schultz Katja

  公开号：US20070190325A1

  公开（公告）日：2007-08-16

  The invention provides a process for producing microcapsules with UV filter activity, wherein at least one type of crosslinkable chromophore with UV-A and/or UV-B and/or UV-C filter activity and optionally at least one type of crosslinkable monomer which does not have UV-A and/or UV-B and/or UV-C filter activity are subjected to a crosslinking reaction in the absence of non-crosslinkable chromophores with UV-A and/or UV-B and/or UV-C filter activity and microcapsules obtainable by this process.

  本发明提供一种制备具有UV过滤活性的微胶囊的方法，其中至少一种具有UV-A和/或UV-B和/或UV-C过滤活性的可交联色团和可选地至少一种不具有UV-A和/或UV-B和/或UV-C过滤活性的可交联单体在无不可交联的具有UV-A和/或UV-B和/或UV-C过滤活性的色团的情况下进行交联反应，并获得由此过程获得的微胶囊。
• MICROCAPSULES WITH UV FILTER ACTIVITY AND PROCESS FOR PRODUCING THEM
  申请人：BERG-SCHULTZ Katja

  公开号：US20120022265A1

  公开（公告）日：2012-01-26

  The invention provides a process for producing microcapsules with UV filter activity, wherein at least one type of crosslinkable chromophore with UV-A and/or UV-B and/or UV-C filter activity and optionally at least one type of crosslinkable monomer which does not have UV-A and/or UV-B and/or UV-C filter activity are subjected to a crosslinking reaction in the absence of non-crosslinkable chromophores with UV-A and/or UV-B and/or UV-C filter activity and microcapsules obtainable by this process.

  本发明提供了一种用于生产具有UV过滤活性的微胶囊的方法，其中至少一种具有UV-A和/或UV-B和/或UV-C过滤活性的可交联色团和可选地至少一种不具有UV-A和/或UV-B和/或UV-C过滤活性的可交联单体在不存在不可交联的具有UV-A和/或UV-B和/或UV-C过滤活性的色团的情况下进行交联反应，以及通过该方法获得的微胶囊。
• US4046771A
  申请人：——

  公开号：US4046771A

  公开（公告）日：1977-09-06