Methyl-3-t-butylcyclobutyl-keton

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Methyl-3-t-butylcyclobutyl-keton
• 英文别名: 1-Acetyl-3-tert.-butyl-cyclobutan；1-(3-Tert-butylcyclobutyl)ethanone
• 化学式: C₁₀H₁₈O
• 分子量: 154.252
• InChiKey: RCXSRYHOYXAFAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Methyl-3-t-butylcyclobutyl-keton 在 过氧化氢苯甲酰 作用下， 生成 3-t-Butylcyclobutyl-acetat
  参考文献：
  名称：

  Enthalpy, entropy, and free-energy changes in the equilibration of cis- and trans-ethyl 3-t-butylcyclobutanecarboxylate and 3-t-butyl-cyclobutanol

  摘要：

  DOI：

  10.1021/jo00832a065
• 作为产物：
  描述：

  3-tert-Butyl-cyclobutanecarbonyl chloride 、 高纯二甲基镉 生成 Methyl-3-t-butylcyclobutyl-keton
  参考文献：
  名称：

  Enthalpy, entropy, and free-energy changes in the equilibration of cis- and trans-ethyl 3-t-butylcyclobutanecarboxylate and 3-t-butyl-cyclobutanol

  摘要：

  DOI：

  10.1021/jo00832a065

文献信息

• ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
  申请人：Smith Nicholas D.

  公开号：US20130231333A1

  公开（公告）日：2013-09-05

  Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

  本文描述了一些雌激素受体调节剂化合物。还描述了包括所述化合物的制药组合物和药物，以及使用这些雌激素受体调节剂，单独或与其他化合物结合，治疗与雌激素受体介导或依赖的疾病或症状的方法。
• AZA-benzothiophenyl compounds and methods of use
  申请人：Savy Pierre Pascal

  公开号：US20080081821A1

  公开（公告）日：2008-04-03

  The invention relates to azabenzothiophenyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzothiophenyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

  本发明涉及一种具有抗癌和/或抗炎活性的Formula I的氮杂苯并噻吩化合物，更具体地，涉及一种抑制MEK激酶活性的氮杂苯并噻吩化合物。本发明提供了用于抑制异常细胞生长或治疗哺乳动物的增殖性疾病或治疗炎症性疾病的组合物和方法。本发明还涉及使用该化合物进行哺乳动物细胞的体外、原位和体内诊断或治疗，或相关病理条件的方法。
• Aza-benzofuranyl compounds and methods of use
  申请人：Savy Pierre Pascal

  公开号：US20080085886A1

  公开（公告）日：2008-04-10

  The invention relates to azabenzofuranyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzofuranyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

  本发明涉及具有抗癌和/或抗炎活性的Formula I的氮杂苯并呋喃化合物，更具体地涉及抑制MEK激酶活性的氮杂苯并呋喃化合物。本发明提供了用于抑制异常细胞生长或治疗哺乳动物的增生性疾病或治疗炎症性疾病的组合物和方法。本发明还涉及使用该化合物进行哺乳动物细胞的体外、原位和体内诊断或治疗，或相关病理条件的方法。
• AZA-INDOLYL COMPOUNDS AND METHODS OF USE
  申请人：Goodacre Simon Charles

  公开号：US20080242655A1

  公开（公告）日：2008-10-02

  The invention relates to azaindolyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to azaindolyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

  本发明涉及具有抗癌和/或抗炎活性的Formula I的吡唑吲哚类化合物，更具体地涉及抑制MEK激酶活性的吡唑吲哚类化合物。本发明提供了用于抑制异常细胞生长或治疗哺乳动物的增生性疾病或治疗炎症性疾病的组合物和方法。本发明还涉及使用该化合物进行哺乳动物细胞的体外、原位和体内诊断或治疗，或相关病理条件的方法。
• PYRIMIDINE PYRAZOLYL DERIVATIVES
  申请人：Ares Trading S.A.

  公开号：US20150141396A1

  公开（公告）日：2015-05-21

  The present invention provides compounds of Formula (I) for the treatment of cancer, rheumatoid arthritis and other diseases.

  本发明提供了式（I）的化合物，用于治疗癌症、类风湿性关节炎和其他疾病。