methyl 3,3,3-trifluoro-2-hydroxy-2-methoxypropanoate | 19607-21-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 3,3,3-trifluoro-2-hydroxy-2-methoxypropanoate
• 英文别名: α-Hydroxy-α-methoxy-perfluorpropansaeure-methylester；2-Hydroxy-2-methoxy-3,3,3-trifluorpropansaeuremethylester；Methyl-α-hydroxy-α-methoxyperfluorpropionat；Methyl 2-hydroxy-2-methoxytrifluoropropionate
• CAS: 19607-21-7
• 化学式: C₅H₇F₃O₄
• 分子量: 188.103
• InChiKey: WHDPPGRMKVQFLX-UHFFFAOYSA-N

物化性质

• 沸点：
  132-133 °C
• 密度：
  1.394±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  甲醇 、 六氟环氧丙烷 生成 methyl 3,3,3-trifluoro-2-hydroxy-2-methoxypropanoate
  参考文献：
  名称：

  Reaction of carboxylic acid fluorides and perfluoropropylene oxide with (acyloxymethyl)dimethylethoxysilanes

  摘要：

  DOI：

  10.1007/bf00922801

文献信息

• Perfluoropropylene oxide in reactions with electrophilic reagents
  作者：I. L. Knunyants、V. V. Shokina、E. I. Mysov

  DOI：10.1007/bf00926132

  日期：1973.12
• Esters of fluorine-containing ?-keto acids in the reaction with amines
  作者：V. I. Saloutin、I. A. Piterskikh、K. I. Pashkevich

  DOI：10.1007/bf00953228

  日期：1986.3
• Some reactions of trifluoropyruvic ester with nucleophilic reagents
  作者：I. L. Knunyants、N. P. Gambaryan、V. V. Tyuleneva

  DOI：10.1007/bf00908491

  日期：1967.12
• Methyl 3,3,3-trifluoropyruvate: an improved procedure starting from hexafluoropropene-1,2-oxide; identification of byproducts
  作者：Bohumil Dolenský、Jaroslav Kvı́čala、Jiřı́ Paleček、Oldřich Paleta

  DOI：10.1016/s0022-1139(02)00007-6

  日期：2002.5

  Optimized laboratory-scale preparation of methyl 3,3,3-trifluoropyruvate (3, MTFP) has been developed starting from industrial hexafluoropropene-1,2-oxide (1, HFPO) via methyl 2,3,3,3-tetrafluoro-2-methoxypropanoate (2, MTPr), which was transformed to 3 using sulfuric acid with isolated yields up to 81%. Byproducts formed in the transformation of 2 to 3, viz. methyl trifluoroacetate (4, MTAc), methyl 3,3,3-trifluoropyruvate hydrate (5), methyl hemiacetal of trifluoropyruvate (6), a dimer of methyl 3,3,3-trifluoropyruvate hydrate (7, DimMTP), and methyl fluorosulfate (8, Sulf) were identified and their amounts determined under various experimental conditions. Potential reaction pathways leading to the formation of the byproducts are discussed. (C) 2002 Elsevier Science B.V. All rights reserved.
• SALOUTIN, V. I.;PITERSKIX, I. A.;PASHKEVICH, K. I., IZV. AN CCCP. CEP. XIM., 1986, N 3, 625-634
  作者：SALOUTIN, V. I.、PITERSKIX, I. A.、PASHKEVICH, K. I.

  DOI：——

  日期：——