2-aminopropyl vinyl ether | 86273-20-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-aminopropyl vinyl ether
• 英文别名: 2-vinyloxypropan-1-amine；2-Vinyl-oxypropan-1-amine；2-ethenoxypropan-1-amine
• CAS: 86273-20-3
• 化学式: C₅H₁₁NO
• mdl: MFCD19203866
• 分子量: 101.148
• InChiKey: LTIMNFWNUWRUNT-UHFFFAOYSA-N

物化性质

• 沸点：
  127-128 °C
• 密度：
  0.8850 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  7
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-aminopropyl vinyl ether 以 丙酮 为溶剂， 反应 3.0h， 生成 1-[5-Hydroxy-2-methyl-1-(2-vinyloxy-propyl)-1H-indol-3-yl]-ethanone
  参考文献：
  名称：

  Synthesis of 5-hydroxy-N-(2-vinyloxyalkyl)indoles from dicarbonyl compounds and vinyloxyalkylamines

  摘要：

  N-(Vinyloxyalkyl)enaminoketones were obtained by the condensation of vinyloxyalkyl-amines with acetylacetone or ethyl acetoacetate. Their subsequent reactions with 1,4-benzoquinone produce the corresponding 5-hydroxy-2-methyl-N-(2-vinyloxyalkyl)indoles in 17-43% yields. The structures of the compounds obtained were confirmed by IR and H-1 NMR spectroscopy.

  DOI：

  10.1007/bf02495263
• 作为产物：
  描述：

  异丙醇胺 、 乙炔 在 氢氧化钾 作用下， 以 苯 为溶剂， 生成 2-aminopropyl vinyl ether
  参考文献：
  名称：

  Synthesis and transformations of vinyl ethers of ethanolamines

  摘要：

  DOI：

  10.1007/bf00844408

文献信息

• Reaction of vinyloxyalkylamines with mercaptoacetic acid
  作者：B. F. Kakharev、V. K. Stankevich、G. R. Klimenko

  DOI：10.1007/bf01435796

  日期：1996.3

  N-[2(3)-Hydroxyalkylj-4-thiazolidinones have been synthesized by the reaction of 2(3)-vinyloxyalkylamines with mercaptoacetic acid in 24–69 % yield. The structure of the compounds obtained was supported by (R and1H NMR spectroscopic data.

  N-[2(3)-羟基烷基j-4-噻唑烷酮是通过 2(3)-乙烯基氧基烷基胺与巯基乙酸反应合成的，产率 24-69%。所得化合物的结构由 (R 和 1 H NMR 光谱数据支持。
• Kukharev, B. F.; Stankevich, V. K.; Klimenko, G. R., Russian Journal of Organic Chemistry, 1995, vol. 31, # 5, p. 591 - 596
  作者：Kukharev, B. F.、Stankevich, V. K.、Klimenko, G. R.

  DOI：——

  日期：——
• Cyclization of vinyl ethers derived from amino alcohols
  作者：B. F. Kukharev、V. K. Stankevich、G. R. Klimenko、V. A. Kukhareva

  DOI：10.1134/s1070428007070044

  日期：2007.7

  Cyclization of vinyl ethers derived from linear and cyclic alpha- and beta-amino alcohols, catalyzed by mercury(II) acetate gave 2-methyloxazolidines and 2-methylperhydro-1,3-oxazines in 37-94% yield.
• ——
  作者：B. F. Kukharev、V. K. Stankevich、G. R. Klimenko

  DOI：10.1023/a:1026040708725

  日期：——

  N-Alkylidene-2(3 or 4)-vinyloxyalkylamines were synthesized in 60-93% yield by reactions of 2(3 or 4)-vinyloxyalkylamines with aliphatic aldehydes. The stability of the resulting Schiff bases and their further transformations were studied.
• Synthesis of 5-hydroxy-N-(2-vinyloxyalkyl)indoles from dicarbonyl compounds and vinyloxyalkylamines
  作者：B. F. Kukharev、V. K. Stankevich、G. R. Klimenko、N. A. Lobanova

  DOI：10.1007/bf02495263

  日期：1997.12

  N-(Vinyloxyalkyl)enaminoketones were obtained by the condensation of vinyloxyalkyl-amines with acetylacetone or ethyl acetoacetate. Their subsequent reactions with 1,4-benzoquinone produce the corresponding 5-hydroxy-2-methyl-N-(2-vinyloxyalkyl)indoles in 17-43% yields. The structures of the compounds obtained were confirmed by IR and H-1 NMR spectroscopy.