(3S,5S)-3,5-Dimethyl-4-heptanol | 82898-91-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3S,5S)-3,5-Dimethyl-4-heptanol
• 英文别名: (3S,5S)-3,5-dimethylheptan-4-ol
• CAS: 82898-91-7
• 化学式: C₉H₂₀O
• 分子量: 144.257
• InChiKey: ZKXITRNXHWEQJU-YUMQZZPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (S)-2-甲基丁醛 在 platinum on activated charcoal 三乙醇胺 、 氢气 作用下， 以 氘代氯仿 为溶剂， 生成 (3S,5S)-3,5-Dimethyl-4-heptanol
  参考文献：
  名称：

  Hoffmann, Reinhard W.; Zeiss, Hans-Joachim; Ladner, Wolfgang, Chemische Berichte, 1982, vol. 115, # 6, p. 2357 - 2370

  摘要：

  DOI：

文献信息

• A convergent synthesis of the C(11)–C(25) fragment of the aglycone of avermectin A2b
  作者：Eric Menager、Eric Merifield、Mark Smallridge、Eric J. Thomas

  DOI：10.1016/s0040-4020(97)00590-5

  日期：1997.7

  Oxidation of the mixture of products obtained by treatment of (S)-2-methylbutanal 8 with the E-but-2-enyldi-isopinocampheylborane prepared from (+)-pinene gave a mixture of homoallylic alcohols from which the major isomer 9 was isolated by chromatography. Oxidation with vanadylacetoacetate and tert-butyl hydroperoxide gave the epoxides 12 and 13, ratio 80 : 20. Following procedures developed in a synthesis of the model spiroacetal 19, 1,3-dithiane was alkylated, firstly using the epoxide 12, and then, after protection of the product 21 so obtained as its acetonide 23, using the epoxide 25, to give the 2,2-dialkylated 1,3-dithiane 25. Deprotection was accompanied by cyclisation to give the spiroacetal 28. Spiroacetal 29 was similarly prepared and taken through to the C(11)-C(25) fragment 38 of the aglycone of avermectin A(2b) 3. (C) 1997 Elsevier Science Ltd.
• HOFFMANN, R. W.;ZEISS, H. -J.;LADNER, W.;TABCHE, S., CHEM. BER., 1982, 115, N 6, 2357-2370
  作者：HOFFMANN, R. W.、ZEISS, H. -J.、LADNER, W.、TABCHE, S.

  DOI：——

  日期：——
• Hoffmann, Reinhard W.; Zeiss, Hans-Joachim; Ladner, Wolfgang, Chemische Berichte, 1982, vol. 115, # 6, p. 2357 - 2370
  作者：Hoffmann, Reinhard W.、Zeiss, Hans-Joachim、Ladner, Wolfgang、Tabche, Susanne

  DOI：——

  日期：——