4-nitro-2-(phenylthio)benzonitrile | 836611-13-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-nitro-2-(phenylthio)benzonitrile
• 英文别名: 4-Nitro-2-phenylsulfanylbenzonitrile
• CAS: 836611-13-3
• 化学式: C₁₃H₈N₂O₂S
• 分子量: 256.285
• InChiKey: OVCGLCVHIAHAQV-UHFFFAOYSA-N

物化性质

• 熔点：
  139-142 °C(Solv: acetone (67-64-1); isopropanol (67-63-0))
• 沸点：
  428.0±40.0 °C(Predicted)
• 密度：
  1.37±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  94.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-nitro-2-(phenylthio)benzonitrile 在 盐酸 、 sodium hydroxide 、 硫酸 、 双氧水 、 溶剂黄146 作用下， 生成 3-nitrothioxanthen-9-one-10,10-dioxide
  参考文献：
  名称：

  Selective Inhibitors of Monoamine Oxidase. 2. Arylamide SAR

  摘要：

  Monoamine oxidase (MAO) exists in two forms distinguishable by substrate specificity. Inhibition of MAO A is believed to be responsible for the antidepressant activity of MAO inhibitors. A group of N-arylacetamides are highly specific inhibitors of MAO A, some with IC50 values in the 10-100 nM range. The requirements for high activity and specificity include a nearly linear tricyclic aromatic portion but a larger and a smaller central ring component. The amide group, which is best acetamido, is optimally placed para to the smaller central group. The size and shape of the aromatic moiety appear to be the major influence on activity and specificity for MAO A.

  DOI：

  10.1021/jm00039a021
• 作为产物：
  描述：

  对硝基苯甲腈 在 dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer 、 copper(II) acetate monohydrate 、 乙酰氯 、 双三氟甲烷磺酰亚胺银盐 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 12.0h， 生成 4-nitro-2-(phenylthio)benzonitrile
  参考文献：
  名称：

  连续的 C-H 活化能够方便地传递多功能芳烃

  摘要：

  从丰富的原料中模块化构建多功能芳烃是合成化学的不懈追求，加速了药物和材料的发现。在此，使用多功能亚胺酸酯的多重 C-H 活化策略，实现了密集功能化的含硫芳烃分子库的便捷传递，从而能够简明地构建生物活性分子，如双苯萘酚。

  DOI：

  10.1039/d1cc03243g

文献信息

• Unusual oxidative dehydration of vic-[alkyl(aryl)thio]-substituted aromatic (heteroaromatic) carboxamides
  作者：P. G. Kislitsyn、F. A. Kucherov、L. N. Chukhrov、S. G. Zlotin、Z. A. Starikova、F. M. Dolgushin

  DOI：10.1023/b:rucb.0000037864.52793.92

  日期：2004.4

  A new procedure was developed for the synthesis of nitriles of vic-[alkyl(aryl)sulfonyl] derivatives of benzoic, anthraquinonecarboxylic, and 4-isothiazolecarboxylic acids by the reactions of the corresponding vic-[alkyl(aryl)thio]-substituted aromatic (heteroaromatic) carboxamides with chlorine in organic solvents containing 20—65% of water. Oxidative dehydration of 1-(butylthio)anthraquinone-2-carboxamide

  通过相应的 vic-[烷基（芳基）硫代]-取代芳烃的反应，开发了一种新的方法来合成苯甲酸、蒽醌羧酸和 4-异噻唑羧酸的 vic-[烷基（芳基）磺酰基]衍生物的腈类（杂芳族）甲酰胺与氯在含有 20-65% 水的有机溶剂中。1-(丁硫基)蒽醌-2-甲酰胺氧化脱水得到1-丁基-6,11-二氢-3H-1λ4-蒽[2,1-d]异噻唑-3,6,11-三酮1-氧化物副产品。后者的结构是通过 X 射线衍射分析确定的。提出了涉及形成 S-氯锍氯化物然后水解的反应方案。
• Efficient Discovery of Potent Anti-HIV Agents Targeting the Tyr181Cys Variant of HIV Reverse Transcriptase
  作者：William L. Jorgensen、Mariela Bollini、Vinay V. Thakur、Robert A. Domaoal、Krasimir A. Spasov、Karen S. Anderson

  DOI：10.1021/ja2058583

  日期：2011.10.5

  Non-nucleoside reverse transcriptase inhibitors (NNRTIs) that interfere with the replication of human immunodeficiency virus (HIV) are being pursued with guidance from molecular modeling including free-energy perturbation (FEP) calculations for protein inhibitor binding affinities. The previously reported pyrimidinylphenylamine 1 and its chloro analogue 2 are potent anti-HIV agents; they inhibit replication of wild-type HIV-1 in infected human T-cells with EC50 values of 2 and 10 nM, respectively. However, they show no activity against viral strains containing the Tyr181Cys (Y181C) mutation in HIV-RT. Modeling indicates that the problem is likely associated with extensive interaction between the dimethylallyloxy substituent and Tyr181. As an alternative, a phenoxy group is computed to be oriented in a manner diminishing the contact with Tyr181. However, this replacement leads to a roughly 1000-fold loss of activity for 3 (2.5 mu M). The present report details the efficient, computationally driven evolution of 3 to novel NNRTIs with sub-10 nM potency toward both wild-type HIV-1 and Y181C-containing variants. The critical contributors were FEP substituent scans for the phenoxy and pyrimidine rings and recognition of potential benefits of addition of a cyanovinyl group to the phenoxy ring.
• Harfenist Morton, Joyner Charles T., Mize Patrick D., White Helen L., J. Med. Chem, 37 (1994) N 13, S 2085-2089
  作者：Harfenist Morton, Joyner Charles T., Mize Patrick D., White Helen L.

  DOI：——

  日期：——
• Sequential C–H activation enabled expedient delivery of polyfunctional arenes
  作者：Wensen Ouyang、Xiaoqing Cai、Xiaojian Chen、Jie Wang、Jianhang Rao、Yang Gao、Yanping Huo、Qian Chen、Xianwei Li

  DOI：10.1039/d1cc03243g

  日期：——

  Modular construction of polyfunctional arenes from abundant feedstocks stands as an unremitting pursue in synthetic chemistry, accelerating the discovery of drugs and materials. Herein, using the multiple C–H activation strategy with versatile imidate esters, the expedient delivery of molecular libraries of densely functionalized sulfur-containing arenes was achieved, which enabled the concise construction

  从丰富的原料中模块化构建多功能芳烃是合成化学的不懈追求，加速了药物和材料的发现。在此，使用多功能亚胺酸酯的多重 C-H 活化策略，实现了密集功能化的含硫芳烃分子库的便捷传递，从而能够简明地构建生物活性分子，如双苯萘酚。
• Selective Inhibitors of Monoamine Oxidase. 2. Arylamide SAR
  作者：Morton Harfenist、Charles T. Joyner、Patrick D. Mize、Helen L. White

  DOI：10.1021/jm00039a021

  日期：1994.6

  Monoamine oxidase (MAO) exists in two forms distinguishable by substrate specificity. Inhibition of MAO A is believed to be responsible for the antidepressant activity of MAO inhibitors. A group of N-arylacetamides are highly specific inhibitors of MAO A, some with IC50 values in the 10-100 nM range. The requirements for high activity and specificity include a nearly linear tricyclic aromatic portion but a larger and a smaller central ring component. The amide group, which is best acetamido, is optimally placed para to the smaller central group. The size and shape of the aromatic moiety appear to be the major influence on activity and specificity for MAO A.