9-guanidino-nonanoic acid | 73427-61-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 9-guanidino-nonanoic acid
• 英文别名: 9-Guanidino-nonansaeure；9-(diaminomethylideneamino)nonanoic acid
• CAS: 73427-61-9
• 化学式: C₁₀H₂₁N₃O₂
• 分子量: 215.296
• InChiKey: BOCSYEQNOHQAAK-UHFFFAOYSA-N

物化性质

• 沸点：
  375.1±44.0 °C(Predicted)
• 密度：
  1.15±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  15
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  102
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  9-guanidino-nonanoic acid 在 硫酸 、 硝酸 、 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 三乙胺 、 [双(三氟乙酰氧基)碘]苯 作用下， 以 水 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 6.0h， 生成 3-[9-(nitroguanidino)nonanoyl]amino-3-aminopropionic acid benzyl ester
  参考文献：
  名称：

  Conformationally flexible platelet aggregation inhibitors based on the tetrapeptide Arg-Gly-Asp-Arg

  摘要：

  A series of nonpeptide fibrinogen receptor antagonists based upon the tetrapeptide Arg-Gly-Asp-Arg were prepared. These relatively simple derivatives incorporate a high degree of conformational flexibility that was anticipated to allow them to attain the requisite conformation for binding to the platelet fibrinogen receptor. Optimization of the distances between the required acidic and basic functional groups led eventually to compound 7, which is a one hundred-fold more potent inhibitor of platelet aggregation than the peptide it is based upon.

  DOI：

  10.1016/s0223-5234(99)80069-5
• 作为产物：
  描述：

  氨基壬酸 生成 9-guanidino-nonanoic acid
  参考文献：
  名称：

  Spergualin-related compounds and process for the preparation thereof

  摘要：

  本发明涉及一种新的与spergualin相关的化合物及其生产方法。这种具有高抗肿瘤活性的新化合物由一般公式##STR1##表示，其中R.sub.1代表氢原子、羟基或具有1至10个碳原子的脂肪酰氧基，R.sub.2代表氨基酸残基（除了α-羟基甘氨酸残基）由α-或ω-氨基和α-羧基中分别去除一个氢原子和羟基得到，该氨基酸残基与相邻的羰基和氨基形成酸酰胺键，m为4至6的整数。

  公开号：

  US04529549A1

文献信息

• Indolyl platelet-aggregation inhibitors
  申请人：Monsanto Co.

  公开号：US05037808A1

  公开（公告）日：1991-08-06

  Novel peptide mimetic compounds are provided which have useful activity as inhibitors of platelet aggregation. These compounds have the chemical structure ##STR1## wherein x=4 to 8, y=0 to 4, W=CH.sub.2 --CH.sub.2 or CH.dbd.CH, Z=H, COOH, CONH.sub.2, CH.sub.2 OH, CO.sub.2 R, CH.sub.2 OR or C.sub.1-6 alkyl, R=C.sub.1-6 alkyl, Ar=a nitrogen-containing heterocyclic group, and Asp=aspartic acid residue.

  提供了一种新型的肽类模拟化合物，其作为血小板聚集抑制剂具有有用的活性。这些化合物具有化学结构##STR1##其中x=4至8，y=0至4，W=CH.sub.2 --CH.sub.2或CH.dbd.CH，Z=H，COOH，CONH.sub.2，CH.sub.2 OH，CO.sub.2 R，CH.sub.2 OR或C.sub.1-6烷基，R=C.sub.1-6烷基，Ar=氮含杂环基团，Asp=天冬氨酸残基。
• Novel platelet-aggregation inhibitors
  申请人：Mosanto Company

  公开号：US04879313A1

  公开（公告）日：1989-11-07

  Novel peptide mimetic compounds are provided which have useful activity as inhibitors of platelet aggregation. These compounds have the chemical structure ##STR1## wherein x=6 to 10, y=0 to 4, Z=H, COOH, CONH.sub.2 or C.sub.1-6 alkyl, Ar=phenyl, biphenyl or napthyl, each substituted with 1 to 3 methoxy groups, or an unsubstituted phenyl, biphenyl, napthyl, pyridyl or thienyl group, and Asp=aspartic acid residue.

  提供了新型肽类模拟化合物，其作为血小板聚集抑制剂具有有用的活性。这些化合物具有化学结构##STR1##其中x = 6至10，y = 0至4，Z = H，COOH，CONH.sub.2或C.sub.1-6烷基，Ar =苯基，联苯或萘基，每个取代1至3个甲氧基或未取代的苯基，联苯，萘基，吡啶基或噻吩基，Asp =天冬氨酸残基。
• Thienyl peptide mimetic compounds which are useful in inhibiting
  申请人：Monsanto Company

  公开号：US04992463A1

  公开（公告）日：1991-02-12

  Novel peptide mimetic compounds are provided which have useful activity as inhibitors of platelet aggregation. These compounds have the chemical structure ##STR1## wherein x=6 to 10, y=0 to 4, Z=H, COOH, CONH.sub.2 or C.sub.1-6 alkyl, Ar=phenyl, biphenyl or napthyl, each substituted with 1 to 3 methoxy groups, or an unsubstituted phenyl, biphenyl, napthyl, pyridyl or thienyl group, and Asp=aspartic acid residue.

  提供了一种新型肽类拟态化合物，其作为血小板聚集抑制剂具有有用的活性。这些化合物具有以下化学结构：##STR1## 其中x=6到10，y=0到4，Z=H、COOH、CONH.sub.2或C.sub.1-6烷基，Ar=苯基、联苯基或萘基，每个取代1到3个甲氧基，或未取代的苯基、联苯基、萘基、吡啶基或噻吩基，Asp=天冬氨酸残基。
• Pyridyl peptide mimetic compounds which are useful platelet-aggregation
  申请人：Monsanto Co.

  公开号：US05091396A1

  公开（公告）日：1992-02-25

  Novel peptide mimetic compounds are provided which have useful activity as inhibitors of platelet aggregation. These compounds have the chemical structure ##STR1## wherein x=4 to 8, y=0 to 4, W=CH.sub.2 --CH.sub.2 or C.dbd.CH, Z=H, COOH, CONH.sub.2, CH.sub.2 OH, CO.sub.2 R, CH.sub.2 OR or C.sub.1-6 alkyl, R=C.sub.1-6 alkyl, Ar=a nitrogen-containing heterocyclic group, and Asp=aspartic acid residue.

  提供了一种新型的肽类模拟化合物，其具有作为血小板聚集抑制剂的有用活性。这些化合物的化学结构为##STR1##其中x=4到8，y=0到4，W=CH.sub.2—CH.sub.2或C.dbd.CH，Z=H，COOH，CONH.sub.2，CH.sub.2OH，CO.sub.2R，CH.sub.2OR或C.sub.1-6烷基，R=C.sub.1-6烷基，Ar=含氮杂环基团，Asp=天冬氨酸残基。
• Spergualin-related compounds, processes for the preparation thereof and their use as medicaments
  申请人：MICROBIAL CHEMISTRY RESEARCH FOUNDATION

  公开号：EP0105193A2

  公开（公告）日：1984-04-11

  This invention relates to novel spergualin-related compounds of the formula (I) wherein R1 represents a hydrogen atom, a hydroxyl group, or an aliphatic acyloxy group with 1 to 10 carbon atoms; R2 represents a residue of an a- or ω-amino acid remaining after removing one of the hydrogen atoms from the a- or ω-amino group and the hydroxyl group from the a-carboxyl group with the proviso that R2 does not include a residue of a-hydroxyglycine, said R2 being attached to the adjacent carbonyl group and amino group by amide bonds; and m denotes an integer of 4 to 6, and their physiologically acceptable salts, and to a process for preparing the same. The compounds according to the present invention exhibit high stability and antitumor activity.

  本发明涉及式 (I) 的新型 spergualin 相关化合物 其中 R1 代表氢原子、羟基或具有 1 至 10 个碳原子的脂肪族酰氧基；R2 代表从 a-或 ω-氨基中去除一个氢原子和从 a-羧基中去除羟基后剩余的 a-或 ω-氨基酸残基，但 R2 不包括 a-羟基甘氨酸残基，所述 R2 通过酰胺键连接到相邻的羰基和氨基上；和 m 表示 4 至 6 的整数，以及它们的生理上可接受的盐和制备它们的工艺。本发明的化合物具有高稳定性和抗肿瘤活性。