Azido-6-(ethanoyloxymethyl)tetrahydro-2H-pyran-3,4,5-triyl triethanoate | 1191420-76-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Azido-6-(ethanoyloxymethyl)tetrahydro-2H-pyran-3,4,5-triyl triethanoate
• 英文别名: (3,4,5-triacetyloxy-6-azidooxan-2-yl)methyl acetate
• CAS: 1191420-76-4
• 化学式: C₁₄H₁₉N₃O₉
• 分子量: 373.32
• InChiKey: NHNYHKRWHCWHAJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  26
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  129
• 氢给体数：
  0
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  Azido-6-(ethanoyloxymethyl)tetrahydro-2H-pyran-3,4,5-triyl triethanoate 、 二聚氰胺 在 zinc dibromide 作用下， 以 水 为溶剂， 反应 1.0h， 以90%的产率得到
  参考文献：
  名称：

  微波辐射下水中环保合成胍基四唑化合物和5-取代的1 H-四唑

  摘要：

  我们已经开发出了一种简单，短时，经济高效的产品，可以通过非色谱方法和环境友好的方案纯化产物，用于通过腈和[2,3]环加成反应合成胍基四唑和5-取代的1 H-四唑衍生物。微波辐射下水中的叠氮化物衍生物。筛选所有合成产物的体外抗菌活性。合成的化合物产率极高（85-98％）。

  DOI：

  10.1016/j.tet.2013.11.069
• 作为产物：
  描述：

  glucose pentaacetate 在 iron(III) chloride 、 叠氮基三甲基硅烷 作用下， 以 二氯甲烷 、 溶剂黄146 为溶剂， 反应 0.33h， 生成 Azido-6-(ethanoyloxymethyl)tetrahydro-2H-pyran-3,4,5-triyl triethanoate
  参考文献：
  名称：

  Ultrasound-assisted one-pot synthesis of anti-CML nucleosides featuring 1,2,3-triazole nucleobase under iron-copper catalysis

  摘要：

  A simple and efficient synthesis of modified 1,2,3-triazole nucleosides was developed. The strategy involved sequential one-pot acetylation-azidation-cycloaddition procedure and was found to be highly effective under a cooperative effect of ultrasound activation and iron/copper catalysis. The reactions were carried out under both conventional and ultrasonic irradiation conditions. In general, improvement in rates and yields were observed when reactions were carried out under sonication compared with conventional conditions. This one-pot procedure provides several advantages such as operational simplicity, high yield, safety and environment friendly protocol. The resulting substituted nucleosides were evaluated for their anticancer activity against K562 chronic myelogenous leukemia (CML) cell line Crown Copyright (C) 2012 Published by Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ultsonch.2012.04.007

文献信息

• COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
  申请人：Washington University

  公开号：US20150197538A1

  公开（公告）日：2015-07-16

  The present invention encompasses compounds and methods for treating urinary tract infections.

  本发明涵盖了用于治疗尿路感染的化合物和方法。
• Biosensors
  申请人：Deshong R. Philip

  公开号：US20070249063A1

  公开（公告）日：2007-10-25

  Methods for detecting a biological interaction comprising administering a substrate comprising a ligand attached to the substrate wherein the ligand binds to a receptor and wherein a signal is produced. Also disclosed is a biosensor comprising a substrate and a ligand wherein the ligand is attached to the surface of the substrate and wherein the ligand preferentially binds to a receptor.
• DENDRITIC STARCH-BASED DEXTRIN ADHESIVES
  申请人：EMPIRE TECHNOLOGY DEVELOPMENT LLC

  公开号：US20130116422A1

  公开（公告）日：2013-05-09

  Starch-based dextrin adhesive additives and methods of preparation are described. Adhesives containing the additive exhibit antimicrobial properties and increased water solubility. The additive contains at least one sugar unit, at least one polyphenol side chain, and at least one Frechet-type poly(aryl ether)dendron.
• US7312194B2
  申请人：——

  公开号：US7312194B2

  公开（公告）日：2007-12-25
• US8518891B2
  申请人：——

  公开号：US8518891B2

  公开（公告）日：2013-08-27