2,2-difluoro-3-(18O)oxidanyl-1,3-diphenylpropan-1-one | 1247822-26-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2,2-difluoro-3-(18O)oxidanyl-1,3-diphenylpropan-1-one
• CAS: 1247822-26-9
• 化学式: C₁₅H₁₂F₂O₂
• 分子量: 264.256
• InChiKey: LMPDXTIOPFEVAU-GTFORLLLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-苄叉苯胺 、 2,2-difluoro-1-phenyl-1-trimethylsiloxyethene 在 zinc trifluoromethanesulfonate 、 重氧水 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以91%的产率得到2,2-difluoro-3-(18O)oxidanyl-1,3-diphenylpropan-1-one
  参考文献：
  名称：

  Reaction of aldimines and difluoroenoxysilane, an unexpected protocol for the synthesis of 2,2-difluoro-3-hydroxy-1-ones

  摘要：

  An unexpected reaction of aldimines and difluoroenoxysilane promoted with Zn(OTf)(2) was disclosed. The reaction gave the unexpected Mukaiyama-aldol adducts 3 in excellent yields (up to 87%) with the addition of H2O and the corresponding Mannich-type adduct 4 was not observed in this catalytic system. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.07.034

文献信息

• Reaction of aldimines and difluoroenoxysilane, an unexpected protocol for the synthesis of 2,2-difluoro-3-hydroxy-1-ones
  作者：Zhi-Liang Yuan、Yin Wei、Min Shi

  DOI：10.1016/j.tet.2010.07.034

  日期：2010.9

  An unexpected reaction of aldimines and difluoroenoxysilane promoted with Zn(OTf)(2) was disclosed. The reaction gave the unexpected Mukaiyama-aldol adducts 3 in excellent yields (up to 87%) with the addition of H2O and the corresponding Mannich-type adduct 4 was not observed in this catalytic system. (C) 2010 Elsevier Ltd. All rights reserved.