4-methyl-4-(methylamino)pentan-2-one | 52221-51-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-methyl-4-(methylamino)pentan-2-one
• 英文别名: 4-Methyl-4-methylamino-pentan-2-on；4-Methyl-4-methylaminopentanon-2；N-Methyl-diacetonamin；Methyl-(β-methylamino-isobutyl)-keton；4-Methyl-4-methylaminopentan-2-one
• CAS: 52221-51-9
• 化学式: C₇H₁₅NO
• mdl: MFCD18815605
• 分子量: 129.202
• InChiKey: WYMGVBJKEPKVNH-UHFFFAOYSA-N

物化性质

• 沸点：
  176.5±23.0 °C(Predicted)
• 密度：
  0.860±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2922399090

反应信息

• 作为反应物：
  描述：

  4-methyl-4-(methylamino)pentan-2-one 在 sodium hydroxide 作用下， 生成 N-(3-benzoyloxyimino-1,1-dimethyl-butyl)-N-methyl-benzamide
  参考文献：
  名称：

  Hochstetter; Kohn, Monatshefte fur Chemie, 1903, vol. 24, p. 777

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲基-3戊烯-2-酮 、 甲胺 生成 4-methyl-4-(methylamino)pentan-2-one
  参考文献：
  名称：

  [EN] PROCESS FOR THE PREPARATION OF CYCLOPROPANE COMPOUNDS USING DIAZO-COM POUNDS
  [FR] PROCÉDÉ DE PRÉPARATION DE COMPOSÉS DE CYCLOPROPANE À L'AIDE DE COMPOSÉS DIAZO

  摘要：

  揭示了一种在多级流动反应器中连续生产二氮化物化合物和底物的反应产物的工艺。

  公开号：

  WO2020002338A1

文献信息

• METHOD FOR THE PREPARATION OF DIAZOALKANES
  申请人：BAKHU LIMITED

  公开号：US20150038687A1

  公开（公告）日：2015-02-05

  The present invention relates to a method of forming diazoalkanes. One aspect of the present invention provides a method for the production of a N-alkyl-N-nitroso compound from a starting material, comprising the use of a tribasic acid to acidify an amine. A second aspect of the present invention provides a method for the production of a diazoalkane, comprising reacting a N-alkyl-N-nitroso compound with a base and a phase transfer catalyst, wherein no organic solvent is used.

  本发明涉及一种形成重氮烷的方法。本发明的一个方面提供了一种从起始物质中生产N-烷基-N-亚硝基化合物的方法，包括使用三元酸使胺酸化。本发明的第二个方面提供了一种形成重氮烷的方法，包括将N-烷基-N-亚硝基化合物与碱和相转移催化剂反应，其中不使用有机溶剂。
• [EN] PROCESS FOR THE CYCLOPROPANATION OF OLEFINS USING N-METHYL-N-NITROSO COMPOUNDS<br/>[FR] PROCÉDÉ DE CYCLOPROPANATION D'OLÉFINES À L'AIDE DE COMPOSÉS N-MÉTHYL-N-NITROSO
  申请人：GIVAUDAN SA

  公开号：WO2017046122A1

  公开（公告）日：2017-03-23

  A process of converting a carbon-carbon double bond on a substrate into a cyclopropane ring, which method comprises the step of treating the substrate with a N-alkyl-N-nitroso compound, a transition metal catalyst and an aqueous base, wherein the N-alkyl-N-nitroso compound is formed by reacting an alkyl amine with an alkali metal nitrite in the presence of a mono-basic or di-basic acid, or a mixture thereof, and wherein the N-alkyl-N-nitroso compound is not distilled before it is mixed with the substrate, catalyst and base.

  将底物上的碳-碳双键转化为环丙烷环的过程，该方法包括用N-烷基-N-亚硝基化合物、过渡金属催化剂和水性碱处理底物的步骤，其中N-烷基-N-亚硝基化合物是通过在单碱性或双碱性酸或二者的混合物存在下将烷基胺与碱金属亚硝酸盐反应而形成的，且N-烷基-N-亚硝基化合物在与底物、催化剂和碱混合之前未经蒸馏。
• [EN] OXYINDOLE DERIVATIVES WITH MOTILIN RECEPTOR AGONISTIC ACTIVITY<br/>[FR] DÉRIVÉS D'OXYINDOLE AYANT UNE ACTIVITÉ AGONISTE AU RÉCEPTEUR DE LA MOTILINE
  申请人：RAQUALIA PHARMA INC

  公开号：WO2010098145A1

  公开（公告）日：2010-09-02

  The present invention relates to novel oxyindole derivatives of formula (I) or a pharmaceutically acceptable salt thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the motilin receptor (GPR38).

  本发明涉及公式（I）的新型氧吲哚衍生物或其药用盐，其制备方法，包含它们的药物组合物以及它们在治疗通过胃动素受体（GPR38）介导的各种疾病中的用途。
• OXYINDOLE DERIVATIVES WITH MOTILIN RECEPTOR AGONISTIC ACTIVITY
  申请人：Sudo Masaki

  公开号：US20110312933A1

  公开（公告）日：2011-12-22

  The present invention relates to novel oxyindole derivatives of formula (I) or a pharmaceutically acceptable salt thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the motilin receptor (GPR38).

  本发明涉及公式（I）的新型氧化吲哚衍生物或其药学上可接受的盐，其制备方法，含有它们的制药组合物以及它们在治疗通过胃动素受体（GPR38）介导的各种疾病中的使用。
• ANTITHROMBOGENIC MATERIAL AND MEDICAL DEVICE
  申请人：Terumo Kabushiki Kaisha

  公开号：EP2749302A1

  公开（公告）日：2014-07-02

  Provided is an antithrombotic material that has an excellent anticoagulant activity and can form a stable coating layer on a base material through a simple and mild coating process. Provided is an antithrombotic material of that includes a copolymer configured to have 75% by mole to 25% by mole of a repeating unit (A) derived from diacetone (meth)acrylamide represented by the following formula (1) (wherein R1 is a hydrogen atom or a methyl group) and 25% by mole to 75% by mole of a repeating unit (B) derived from a monomer having at least one sulfonate group selected from a group consisting of 2-(meth)acrylamide-2-methyl-propane sulfonic acid, vinyl sulfate, allyl sulfate, styrenesulfonic acid, sulfoethyl (meth)acrylate, and sulfopropyl (meth)acrylate in a molecule, or a salt of the monomer (the total amount of the repeating unit (A) and the repeating unit (B) is 100% by mole). [Chem. 1]

  本发明提供了一种抗血栓材料，它具有优异的抗凝血活性，并能通过简单温和的涂覆工艺在基底材料上形成稳定的涂覆层。硫酸乙烯酯、硫酸烯丙基酯、苯乙烯磺酸、(甲基)丙烯酸磺酰乙酯和(甲基)丙烯酸磺丙酯或单体盐（重复单元(A)和重复单元(B)的总量为 100%摩尔）。 [化学 1］