triacetonamine | 63206-89-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: triacetonamine
• 英文别名: 1-[Bis(2-oxopropyl)amino]propan-2-one
• CAS: 63206-89-3
• 化学式: C₉H₁₅NO₃
• 分子量: 185.223
• InChiKey: CMPVWWOUALPDDA-UHFFFAOYSA-N

物化性质

• 沸点：
  277.7±35.0 °C(Predicted)
• 密度：
  1.054±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  54.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  triacetonamine 在 盐酸羟胺 、 sodium acetate 作用下， 以 水 为溶剂， 反应 0.5h， 以95%的产率得到2,2,6,6-四甲基-4-哌啶酮肟
  参考文献：
  名称：

  Electron Paramagnetic Resonance (EPR) Study of Spin-Labeled Camptothecin Derivatives: A Different Look of the Ternary Complex

  摘要：

  Camptothecin (CPT) derivatives are clinically effective poisons of DNA topoisomerase I (Top 1) able to form a ternary complex with the Top1 DNA complex. The aim of this investigation was to examine the dynamic aspects of the ternary complex formation by means of site-directed spin labeling electron paramagnetic resonance (SDSL-EPR). Two semisynthetic CPT derivatives bearing the paramagnetic moiety were synthesized, and their biological activity was tested. A 22-mer DNA oligonucleotide sequence with high affinity cleavage site for Top1 was also synthesized. EPR experiments were carried out on modified CPT in the presence of DNA, of Top1, or of both. In the last case, a slow motion component in the EPR signal appeared, indicating the formation of the ternary complex. Deconvolution of the EPR spectrum allowed to obtain the relative drug amounts in the complex. It was also possible to demonstrate that the residence time of CPT "trapped" in the ternary complex is longer than hundreds of microseconds.

  DOI：

  10.1021/jm101232t
• 作为产物：
  描述：

  4-甲基-3戊烯-2-酮 以 丙酮 为溶剂， 生成 triacetonamine
  参考文献：
  名称：

  Process for preparing 2,2,6,6-tetraalkyl-4-oxopiperidines

  摘要：

  一种生产式(I)的哌啶的方法##STR1##其中R.sub.1是氢或C.sub.1-C.sub.4-烷基，从式(II)的酮中获得R.sub.1--CH.sub.2--C(O)--CH.sub.3，其中R.sub.1具有上述给定的含义，并使用氨作为催化剂，在该过程中使用具有中等或大孔径尺寸或具有大孔隙的强酸离子交换剂。

  公开号：

  US04275211A1

文献信息

• [EN] BICYCLIC PEPTIDE LIGAND STING CONJUGATES AND USES THEREOF<br/>[FR] CONJUGUÉS LIGANDS PEPTIDIQUES BICYCLIQUES ET LEURS UTILISATIONS
  申请人：BICYCLERD LTD

  公开号：WO2019034866A1

  公开（公告）日：2019-02-21

  The present invention provides compounds, compositions thereof, and methods of using the same.

  本发明提供了化合物、其组合物以及使用方法。
• [EN] BICYCLIC PEPTIDE LIGAND STING CONJUGATES AND USES THEREOF<br/>[FR] CONJUGUÉS PEPTIDE-LIGAND BICYCLIQUE ET LEURS UTILISATIONS
  申请人：BICYCLETX LTD

  公开号：WO2020165600A1

  公开（公告）日：2020-08-20

  The present invention provides compounds, compositions thereof, and methods of using the same.

  本发明提供了化合物、其组合物以及使用方法。
• GLUCOSE-RESPONSIVE INSULIN CONJUGATES
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20150105317A1

  公开（公告）日：2015-04-16

  Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.

  本发明涉及胰岛素共轭物，包括将胰岛素分子共价连接至至少一个双齿配体的连接物中，每个配体独立连接到包含一种含糖和其中至少一个连接物的配体的糖类，其中连接物的至少一个配体的糖类为岩藻糖。这些胰岛素共轭物展示出对系统浓度的糖类（如葡萄糖或α-甲基甘露糖）具有响应的药代动力学（PK）和/或药效动力学（PD）特性，即使在给予需要的受试者时，也不需要外源多价糖类结合分子（如Con A）。
• Imidazolidinone nitroxides as electrode materials for energy storage devices
  申请人：Nesvadba Peter

  公开号：US20090274947A1

  公开（公告）日：2009-11-05

  The invention relates to a an electrical energy storage device, such as a capacitor or a secondary battery, utilizing as active element the oxidation and reduction cycle of a sterically hindered imidazolidinone nitroxide radical. Further aspects of the invention are a method for providing such an energy storage device, the use of the respective compounds as active elements in energy storage devices and selected novel imidazolidinone nitroxide compounds.

  该发明涉及一种电能储存装置，例如电容器或二次电池，利用立体位阻咪唑啉酮亚硝基自由基的氧化还原循环作为活性元素。该发明的进一步方面包括提供这种能量储存装置的方法，将相应化合物用作能量储存装置中的活性元素以及选定的新型咪唑啉酮亚硝基化合物。
• SYNTHESIS OF TRIACETONEDIAMINE COMPOUNDS BY REDUCTIVE AMINATION PROCEEDING FROM TRIACETONEDIAMINE AND DERIVATIVES THEREOF
  申请人：Evonik Degussa GmbH

  公开号：US20180009734A1

  公开（公告）日：2018-01-11

  An N-substituted triacetonediamine compound is produced by reacting 4-amino-2,2,6,6-tetramethylpiperidine or a derivative thereof with a carbonyl compound in a reductive amination.

  通过在还原胺化反应中将4-氨基-2,2,6,6-四甲基哌啶或其衍生物与羰基化合物反应，可以制备N-取代的三乙酮二胺化合物。