4-<4-Acetyl-phenyl>-thiosemicarbazid | 93114-15-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-<4-Acetyl-phenyl>-thiosemicarbazid
• 英文别名: N-(4-acetylphenyl)hydrazinecarbothioamide；1-(4-acetylphenyl)-3-aminothiourea
• CAS: 93114-15-9
• 化学式: C₉H₁₁N₃OS
• 分子量: 209.272
• InChiKey: MQEVWQQRCKUCPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  68.5
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-<4-Acetyl-phenyl>-thiosemicarbazid 、 对硝基苯甲醛 以85%的产率得到
  参考文献：
  名称：

  BAYOUMY, BASHER EL-SAYED, J. SERB. CHEM. SOC., 55,(1990) N, C. 205-211

  摘要：

  DOI：

文献信息

• F-18 peptides for pre targeted positron emission tomography imaging
  申请人：McBride J. William

  公开号：US20070048217A1

  公开（公告）日：2007-03-01

  F-18 radiolabeled peptides are prepared by reacting a peptide comprising a hydroxylamine, a thiosemicarbazide, a hydrazine or a free amine group with 4-[ 18 F]Fluorobenzaledyde. Specific, non-limiting examples of F-18 radiolabeled peptides are described herein. The labeled peptides are useful, for example, in clinical positron emission tomography.

  F-18放射性标记的肽类是通过将含有羟胺、硫脲、肼或自由胺基团的肽与4-[18F]氟苯甲醛反应制备而成。本文介绍了F-18放射性标记肽的具体非限制性例子。标记的肽类在临床正电子发射断层扫描等方面具有实用价值。
• Methods and Compositions for F-18 Labeling of Proteins, Peptides and Other Molecules
  申请人：McBride William J.

  公开号：US20090155166A1

  公开（公告）日：2009-06-18

  The present application discloses compositions and methods of synthesis and use of F-18 labeled molecules of use, for example, in PET imaging techniques. The labeled molecules may be peptides or proteins, although other types of molecules may be labeled by the described methods. Preferably, the F-18 may be conjugated to a targeting molecule by formation of a metal complex and binding of the F-18-metal complex to a chelating moiety. Alternatively, the metal may first be conjugated to the chelating group and subsequently the F-18 bound to the metal. In other embodiments, the F-18 labeled moiety may comprise a targetable construct used in combination with a bispecific or multi specific antibody to target F-18 to a disease-associated antigen, such as a tumor-associated antigen. The F-18 labeled targetable construct peptides are stable in serum at 37° C. for a sufficient time to perform PET imaging analysis.
• US7842279B2
  申请人：——

  公开号：US7842279B2

  公开（公告）日：2010-11-30
• US7993626B2
  申请人：——

  公开号：US7993626B2

  公开（公告）日：2011-08-09