1,2,3,4,5,6,7,8,9,10,11,14-Dodecahydrophenanthridin | 16726-22-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1,2,3,4,5,6,7,8,9,10,11,14-Dodecahydrophenanthridin
• 英文别名: tetradecahydro-phenanthridine；Perhydrophenanthri-dine；1,2,3,4,4a,5,6,6a,7,8,9,10,10a,10b-tetradecahydrophenanthridine
• CAS: 16726-22-0；16726-23-1；16726-24-2；55176-79-9
• 化学式: C₁₃H₂₃N
• mdl: MFCD20547670
• 分子量: 193.332
• InChiKey: GVFDNYSRFCNIRM-UHFFFAOYSA-N

物化性质

• 沸点：
  284.4±8.0 °C(Predicted)
• 密度：
  0.936±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• TERTIARY AMINE COMPOUND OR IMINE COMPOUND-POLYMER CONJUGATE AND PRODUCTION METHOD THEREFOR
  申请人：Seikagaku Corporation

  公开号：US20200138964A1

  公开（公告）日：2020-05-07

  Provided is a compound obtained by conjugating a tertiary amine compound or imine compound, which is useful as a drug, with a polymer, in which a structure D + having a quaternary ammonium salt or iminium salt formed from a tertiary amine compound or imine compound D and a polymer residue Poly having a carboxy group are bonded to each other via a structure —C(R 1 )(R 2 )OC(O)ANHC(═O)—.

  提供的是一种化合物，通过将一种三级胺化合物或亚胺化合物与聚合物共轭，用作药物，其中具有由三级胺化合物或亚胺化合物D形成的季铵盐或亚胺盐的结构D + 和具有羧基的聚合物残基Poly通过结构—C(R 1 )(R 2 )OC(O)ANHC(═O)—相互键合。
• PRIMARY AMINE COMPOUND OR SECONDARY AMINE COMPOUND-ACIDIC POLYSACCHARIDE CONJUGATE AND PRODUCTION METHOD THEREFOR
  申请人：Seikagaku Corporation

  公开号：US20220040318A1

  公开（公告）日：2022-02-10

  Provided is a novel conjugate of a primary or secondary amine compound with an acidic polysaccharide, which is a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof, where in Formula (I), D, R 1 , R 2 , A, and Poly are as defined in the specification.

  提供的是一种主要或次要胺化合物与酸性多糖结合的新型共轭物，该化合物由式（I）表示或其药用盐，其中在式（I）中，D、R1、R2、A 和 Poly 如规范中定义。
• Preparation of (polycyclic secondary-amino) dialkoxysilane
  申请人：Ube Industries, Ltd.

  公开号：US20010051723A1

  公开（公告）日：2001-12-13

  A (polycyclic secondary-amino)dialkoxysilane favorably employable as a catalyst for polymerization of &agr;-olefin can be prepared by reacting tetrachlorosilane or a mono (C 1 -C 8 ) alkyltrichlorosilane with a polycyclic secondary-amine in a non-hydrous, non-alcoholic organic solvent in the presence of a hydrogen chloride-trapping reagent, to produce a (polycyclic secondary-amino) chlorosilane and reacting the (polycyclic secondary-amino) chlorosilane with an alkali metal alkoxide or an alkaline earth metal alkoxide in the presence of a lower alcohol.

  一种（多环二级胺）二烷氧基硅烷，可优选作为α-烯烃聚合催化剂，可通过将四氯硅烷或单（C1-C8）烷基三氯硅烷与一种多环二级胺在无水、非醇类有机溶剂中，在氯化氢捕集试剂存在下反应，生成（多环二级胺）氯硅烷，然后将（多环二级胺）氯硅烷与碱金属烷氧化物或碱土金属烷氧化物在较低醇的存在下反应制备。
• Catalysts for polymerization or copolymerization of alpha-olefins, catalyst components thereof, and processes for polymerization of alpha-olefins with the catalysts
  申请人：Yoshikiyo Motozo

  公开号：US20050202958A1

  公开（公告）日：2005-09-15

  The invention has an object to provide a catalyst for polymerizing or copolymerizing an α-olefin, catalyst constituent thereof, and method of polymerizing α-olefins with the catalyst, for production of α-olefin polymers or copolymers with high hydrogen response, high polymarization reaction rate, high stereoregularity and excellent melt fluidity. The invention discloses a catalyst constituent of the catalyst for polymerizing or copolymerizing an α-olefin, represented by Formula 37 or 38: Si(OR 1 ) 3 (NR 2 R 3 )  Formula 37 (where in Formula 37, R 1 is a hydrocarbon group with 1 to 6 carbon atoms; R 2 is a hydrocarbon group with 1 to 12 carbon atoms or hydrogen; and R 3 is a hydrocarbon group with 1 to 12 carbon atoms) RNSi(OR 1 ) 3 Formula 38 (where in Formula 38, R 1 is a hydrocarbon group with 1 to 6 carbon atoms; and RN is a cyclicl amino group).

  本发明旨在提供一种用于聚合或共聚α-烯烃的催化剂、其催化剂成分和α-烯烃聚合的方法，用于生产具有高氢响应、高聚合反应速率、高立体规整度和优异熔融流动性的α-烯烃聚合物或共聚物。该发明公开了用于聚合或共聚α-烯烃的催化剂成分，由式37或38表示：Si（OR1）3（NR2R3）  式37（其中，在式37中，R1是具有1至6个碳原子的烃基；R2是具有1至12个碳原子或氢原子的烃基；R3是具有1至12个碳原子的烃基）RNSi（OR1）3  式38（其中，在式38中，R1是具有1至6个碳原子的烃基；RN是环状氨基基团）。
• NITROGENOUS HETEROCYCLIC COMPOUND AND MEDICINAL USE THEREOF
  申请人：Ochiai Hiroshi

  公开号：US20090233908A1

  公开（公告）日：2009-09-17

  A compound represented by formula (I): (wherein the symbols are the same as defined in the description), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof, and medicinal use thereof. The compound represented by formula (I) has CXCR4 antagonistic activity. It is hence useful as, e.g., a preventive and/or therapeutic agent for CXCR4-mediated diseases such as inflammatory/immunologic diseases (e.g., rheumatoid arthritis, arthritis, retinopathy, pulmonary fibrosis, and rejection reactions of transplanted organs), allergic diseases, infections diseases (e.g., human immunodeficiency virus infection and acquired immunologic deficiency syndrome), psychoneurotic diseases, cerebral diseases, cardiac/vascular disease, metabolic diseases, cancer diseases (e.g., cancer, cancer metastasis) or as an agent for regeneration therapy.

  化合物的化学式为（I）：（其中符号的定义与说明书中相同），其盐，N-氧化物，溶剂化合物或前药，以及其药用。化合物（I）具有CXCR4拮抗活性。因此，它可用作预防和/或治疗CXCR4介导疾病的药物，例如炎症/免疫疾病（例如类风湿性关节炎，关节炎，视网膜病变，肺纤维化和移植器官的排斥反应），过敏性疾病，感染性疾病（例如人类免疫缺陷病毒感染和获得性免疫缺陷综合症），心理神经疾病，脑部疾病，心血管疾病，代谢性疾病，癌症（例如癌症，癌症转移）或再生治疗剂。