7-((2-(3,5-Dibromo-4-hydroxyphenyl)ethyl)amino)-5,8-quinolinedione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-((2-(3,5-Dibromo-4-hydroxyphenyl)ethyl)amino)-5,8-quinolinedione
• 英文别名: 7-[2-(3,5-dibromo-4-hydroxyphenyl)ethylamino]quinoline-5,8-dione
• 化学式: C₁₇H₁₂Br₂N₂O₃
• 分子量: 452.1
• InChiKey: OHPHDPYJEHZGDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  79.3
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• RESIN COMPOSITION FOR FOAM, FOAM, AND WALLPAPER
  申请人：Toppan Printing Co., Ltd.

  公开号：EP2832783A1

  公开（公告）日：2015-02-04

  A resin foam composition comprises, at least, a resin emulsion and cellulose nanofibers.

  树脂泡沫组合物至少包括树脂乳液和纤维素纳米纤维。
• Resin foam composition and foam, and wallpaper
  申请人：Toppan Printing Co., Ltd.

  公开号：US11161953B2

  公开（公告）日：2021-11-02

  A resin foam composition comprises, at least, a resin emulsion and cellulose nanofibers.

  树脂泡沫组合物至少包括树脂乳液和纤维素纳米纤维。
• T5 exonuclease-based method to identify DNA topoisomerase inhibitors
  申请人：Leng Fenfei

  公开号：US11268129B1

  公开（公告）日：2022-03-08

  The present invention provides assays and methods for studying DNA topology and topoisomerases. The assays and methods utilize a circular plasmid DNA comprising one or more hairpin structures and the ability of T5 exonuclease (T5E) to digest the circular plasmid DNA in a specific configuration. The assays and methods can be used as a high throughput screening for inhibitors of, for example, DNA gyrases and DNA topoisomerases I for anticancer drug and antibiotics discovery.

  本发明提供了研究DNA拓扑结构和拓扑异构酶的检测方法。这些检测方法利用包含一个或多个发夹结构的环状质粒 DNA 以及 T5 外切酶（T5E）以特定构型消化环状质粒 DNA 的能力。这些检测方法可用于高通量筛选 DNA 回旋酶和 DNA 拓扑异构酶 I 等的抑制剂，以发现抗癌药物和抗生素。
• Protein tyrosine phosphatase-prl-1 a a marker and therapeutic target for pancreatic cancer
  申请人：Farnsworth L Amanda

  公开号：US20070026398A1

  公开（公告）日：2007-02-01

  Using gene expression profiling, the present Invention identifies Protein tyrosine phosphatase IVA member 1 (PRL-1) as a diagnostic marker and therapeutic target for pancreatic cancer. The Invention therefore provides methods for prediction and detection of PRL-1 associated cancers, and evaluation of inhibitors of PRL-1. The Invention also provides a method of treating or preventing pancreatic cancer in a subject.
• METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS
  申请人：Reed John C.

  公开号：US20090118135A1

  公开（公告）日：2009-05-07

  An assay for determining compounds that inhibit activity of a BCl-2 protein, or affect conversion of Bcl-2 from an antiapoptotic to a proapoptotic form are described. In addition, compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and related Bcl-2 family members are identified.