9-Chlorobenzo[c]quinolizin-11-ium-6-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-Chlorobenzo[c]quinolizin-11-ium-6-amine
• 化学式: C13H10ClN2+
• 分子量: 229.68
• InChiKey: PMELBOKYEHBOID-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] CFTR CHANNEL ACTIVATOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME<br/>[FR] COMPOSES ACTIVATEURS DU CANAL CFTR, ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

  公开号：WO1998005642A1

  公开（公告）日：1998-02-12

  (EN) CFTR channel activator compounds from the benzo[c]quinolizinium family or families of compounds derived therefrom, as well as pharmaceutical compositions containing said compounds, and the uses thereof, particularly for treating cystic fibrosis, are disclosed.(FR) La présente invention a pour objet des composés activateurs du canal CFTR, appartenant à la famille des benzo[c]quinoliziniums, ou à des familles de composés dérivées de cette dernière, ainsi que les compositions pharmaceutiques contenant ces composés, et leurs utilisations, notamment dans le cadre du traitement de la mucoviscidose.

  (中)本发明涉及来自苯并[c]喹啉族或其衍生物族的CFTR通道激活剂化合物，以及含有该化合物的药物组合物和其用途，特别是用于治疗囊性纤维化。
• COMPOSES ACTIVATEURS DU CANAL CFTR, ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

  公开号：EP0937044B1

  公开（公告）日：2002-01-30
• Use of Glucosidase Inhibitors for Therapy of Mucovisidosis
  申请人：Becq Frèdèric

  公开号：US20070213357A1

  公开（公告）日：2007-09-13

  The invention relates to the use of glycosidase inhibitors selected from compounds of general formula (1), wherein R 1 represents a CH 3 group, or CH 2 OH, R 2 represents H or an alkyl group having 1-5 carbon atoms, or R 1 and R 2 together form a group having formula (II), with carbon in position (a) and nitrogen of formula (I) mentioned above, for the preparation of a medicament used to treat mucoviscidosis.
• USE OF GLUCOSIDASE INHIBITORS FOR THERAPY OF MUCOVISIDOSIS
  申请人：BECQ Frédéric

  公开号：US20110269795A1

  公开（公告）日：2011-11-03

  A method provides for the use of glycosidase inhibitors selected from compounds of general formula (1), wherein R 1 represents a CH 3 group, or CH 2 OH, R 2 represents H or an alkyl group having 1-5 carbon atoms, or R 1 and R 2 together form a group having formula (II), with carbon in position (a) and nitrogen of formula (I) mentioned above, for the preparation of a medicament used to treat mucovisidosis. A corresponding product is also described.
• US7897610B2
  申请人：——

  公开号：US7897610B2

  公开（公告）日：2011-03-01