11-chloro-5H-indolo[3,2-b]quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 11-chloro-5H-indolo[3,2-b]quinoline
• 化学式: C₁₅H₉ClN₂
• 分子量: 252.7
• InChiKey: ISUJBZJCNWVRRD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Condensed quinoline system compound and process of preparation thereof
  申请人：MECT CORPORATION

  公开号：EP0376166A1

  公开（公告）日：1990-07-04

  Novel condensed quinoline system compounds such as indenoquinoline system compounds, indoloquinoline system compounds, benzothienoquinoline system compounds and benzofuranoquinoline system compounds, and a process for preparation of these compounds are provided. The present invention is also directed to salts of the above compounds. The compounds of the present invention are effective for inhibition of KB-cell growth and prolongation of life span in cancer implanted mice.

  本发明提供了新型缩合喹啉系化合物，如茚并喹啉系化合物、吲哚并喹啉系化合物、苯并噻吩并喹啉系化合物和苯并呋喃并喹啉系化合物，以及制备这些化合物的工艺。本发明还涉及上述化合物的盐类。本发明的化合物可有效抑制 KB 细胞的生长，延长癌症植入小鼠的寿命。
• QUINDOLINE COMPOUNDS AND USES THEREOF
  申请人：Arizona Board of Regents on Behalf of the University of Arizona

  公开号：US20220098210A1

  公开（公告）日：2022-03-31

  This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a quindoline (or similar) structure which function as stabilizers of G-quadruplex (G4) formation, and their use as therapeutics for the treatment of cancer (e.g., castration-resistant prostate cancer), and other conditions mediated by G4 stabilization.
• US5681958A
  申请人：——

  公开号：US5681958A

  公开（公告）日：1997-10-28
• US5741926A
  申请人：——

  公开号：US5741926A

  公开（公告）日：1998-04-21
• US5925647A
  申请人：——

  公开号：US5925647A

  公开（公告）日：1999-07-20