methyl [7-oxo-4,5,6,7-tetrahydro-benzothiazol-2-yl]-carbamidate | 883864-78-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl [7-oxo-4,5,6,7-tetrahydro-benzothiazol-2-yl]-carbamidate
• 英文别名: Methyl (7-oxo-4,5,6,7-tetrahydrobenzothiazol-2-yl)carbamate；methyl N-(7-oxo-5,6-dihydro-4H-1,3-benzothiazol-2-yl)carbamate
• CAS: 883864-78-6
• 化学式: C₉H₁₀N₂O₃S
• 分子量: 226.256
• InChiKey: QWWSJJHWYLJAGF-UHFFFAOYSA-N

物化性质

• 密度：
  1.460±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  96.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-amino-5,6-dihydro-4H-benzothiazol-7-one 、 氯甲酸甲酯 以 四氢呋喃 为溶剂， 生成 methyl [7-oxo-4,5,6,7-tetrahydro-benzothiazol-2-yl]-carbamidate
  参考文献：
  名称：

  Thiazolyl-Dihydro-Indazole

  摘要：

  本发明涵盖了一般式（1）的化合物 其中 R1至R6如权利要求书中所定义 ，适用于治疗以细胞过度或异常增殖为特征的疾病，并且用于制备具有上述特性的药物。

  公开号：

  US20080081802A1

文献信息

• [EN] THIAZOLYL-DIHYDRO-INDAZOLES<br/>[FR] THIAZOLYLDIHYDROINDAZOLES
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2009112565A1

  公开（公告）日：2009-09-17

  The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

  本发明涵盖了一般式（1）中R1至R3的化合物，其中R1至R3的定义如权利要求书中所述，适用于治疗以细胞过度或异常增殖为特征的疾病，并用于制备具有上述特性的药物。
• Thiazolyl-dihydro-indazole
  申请人：Betzemeier Bodo

  公开号：US20060100254A1

  公开（公告）日：2006-05-11

  The present invention encompasses compounds of the general formula (1) in which R 1 to R 3 are defined as in Claim 1, which are suitable for treating diseases which are characterized by excessive or anomalous cell proliferation, and their use for producing a pharmaceutical having the abovementioned properties.

  本发明涵盖一般式（1）中定义如权利要求1中的R1至R3的化合物，这些化合物适用于治疗由过度或异常细胞增殖特征的疾病，并且它们用于制造具有上述特性的药物。
• THIAZOLYL-DIHYDRO-INDAZOLES
  申请人：BETZEMEIER Bodo

  公开号：US20100113414A1

  公开（公告）日：2010-05-06

  The present invention encompasses compounds of the general formula (1) in which R 1 to R 3 are defined as in claim 1 , which are suitable for treating diseases which are characterized by excessive or anomalous cell proliferation, and their use for producing a pharmaceutical having the abovementioned properties.

  本发明涵盖了通式（1）中定义如权利要求1中的R1至R3的化合物，适用于治疗以过度或异常细胞增殖为特征的疾病，并且它们的用途用于制备具有上述特性的药物。
• Thiazolyl-Dihydro-Indazoles
  申请人：McCONNELL Darryl

  公开号：US20120108567A1

  公开（公告）日：2012-05-03

  The present invention encompasses compounds of general formula (1) wherein R 1 to R 3 are defined as in claim 1 , which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

  本发明涵盖了一般式（1）的化合物，其中R1到R3的定义如权利要求书中所述，适用于治疗由过度或异常细胞增殖所表征的疾病，并且其用于制备具有上述特性的药物。
• Thiazolyl-dihydro-indazoles
  申请人：Boehringer Ingelheim International GmbH

  公开号：US08207349B2

  公开（公告）日：2012-06-26

  The present invention encompasses compounds of the general formula (1) in which R1 to R3 are defined as in claim 1, which are suitable for treating diseases which are characterized by excessive or anomalous cell proliferation, and their use for producing a pharmaceutical having the abovementioned properties.

  本发明涵盖了一般式（1）中定义如权利要求1中的R1至R3的化合物，适用于治疗由于细胞过度或异常增殖而表现出的疾病，并且它们的用途是生产具有上述特性的制药产品。