N1,N7-bis(2-diethylaminoethyl)-3,9-dimethyl-quinolino[8,7-h]quinoline-1,7-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N1,N7-bis(2-diethylaminoethyl)-3,9-dimethyl-quinolino[8,7-h]quinoline-1,7-diamine
• 英文别名: 1-N,7-N-bis[2-(diethylamino)ethyl]-3,9-dimethylquinolino[8,7-h]quinoline-1,7-diamine
• 化学式: C₃₀H₄₂N₆
• 分子量: 486.7
• InChiKey: YDXDIPBVWWLCOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  36
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  56.3
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• METHODS OF INHIBITING VIRAL INFECTION
  申请人：Functional Genetics, Inc.

  公开号：EP2207801B1

  公开（公告）日：2013-04-17
• METHOHDS OF INHIBITING VIRAL INFECTION
  申请人：Kinch Michael

  公开号：US20090170890A1

  公开（公告）日：2009-07-02

  A method of inhibiting viral infection in a mammal in need of same, includes administering an effective amount of at least one of the compounds of FGI-103 which are represented by 273, 365 and 510 either prophylactically to prevent viral infection, or therapeutically following viral infection. These compounds appear to selectively inhibit Caspase 8 as a method of preventing infective viral particle release. They can be administered IV, IP, orally or via other conventional administration routes. The compounds are highly effective, requiring relatively low dosages on the order of 1 ng/kg-200 mg/kg of body weight.
• US8207209B2
  申请人：——

  公开号：US8207209B2

  公开（公告）日：2012-06-26
• [EN] METHODS OF INHIBITING VIRAL INFECTION<br/>[FR] PROCÉDÉS VISANT À INHIBER UNE INFECTION VIRALE
  申请人：FUNCTIONAL GENETICS INC

  公开号：WO2009055524A1

  公开（公告）日：2009-04-30

  A method of inhibiting viral infection in a mammal in need of same, includes administering an effective amount of at least one of the compounds of FGI- 103 which are represented by 273, 365 and 510 either prophylactically to prevent viral infection, or therapeutically following viral infection. These compounds appear to selectively inhibit Caspase 8 as a method of preventing infective viral particle release. They can be administered IV, IP, orally or via other conventional administration routes. The compounds are highly effective, requiring relatively low dosages on the order of 1 ng/kg - 200 mg/kg of body weight.