trans-2-<2-Propyloxy-phenyl>-aethylen-1-carbonsaeure | 60491-05-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: trans-2-<2-Propyloxy-phenyl>-aethylen-1-carbonsaeure
• 英文别名: trans-2-<2-Propyloxy-phenyl>-aethylen-1-carbonsaeure(trans-o-Propyloxy-zimtsaeure)；trans-o-Propyloxy-zimtsaeure；2-propoxy-trans-cinnamic acid；2-Propoxy-trans-zimtsaeure；(2E)-3-(2-propoxyphenyl)prop-2-enoic acid；(E)-3-(2-propoxyphenyl)prop-2-enoic acid
• CAS: 60491-05-6
• 化学式: C₁₂H₁₄O₃
• 分子量: 206.241
• InChiKey: AVGAJRVCSFECRC-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  甲醇 、 trans-2-<2-Propyloxy-phenyl>-aethylen-1-carbonsaeure 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Stoermer, Chemische Berichte, 1911, vol. 44, p. 644

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 乙醚 、 溴 作用下， 生成 trans-2-<2-Propyloxy-phenyl>-aethylen-1-carbonsaeure
  参考文献：
  名称：

  Stoermer, Chemische Berichte, 1911, vol. 44, p. 644

  摘要：

  DOI：

文献信息

• [EN] [1,3]DIOXOLO[4,5-G]QUINOLINE-6(5H)THIONE AND [1,3]DIOXOLO[4,5-G][1,2,4]TRIAZOLO[1,5-A]QUINOLINE DERIVATIVES AS INHIBITORS OF THE LATE SV40 FACTOR (LSF) FOR USE IN TREATING CANCER<br/>[FR] DÉRIVÉS DE [1,3]DIOXOLO[4,5-G]QUINOLINE-6(5H)THIONE ET DE [1,3]DIOXOLO[4,5-G][1,2,4]TRIAZOLO[1,5-A]QUINOLINE COMME INHIBITEURS DU FACTEUR TARDIF DE TRANSCRIPTION DE SV40 (LSF) POUR L'UTILISATION DANS LE TRAITEMENT DU CANCER
  申请人：UNIV BOSTON

  公开号：WO2013052465A1

  公开（公告）日：2013-04-11

  The present invention relates generally to [l,3]dioxolo[4,5-g]quinoline-6(5H)thione and [1,3]dioxolo[4,5-g][1,2,4]triazolo[1,5-a]quinoline derivatives and/or compositions for use in inhibiting, preventing and/or treating cancer, e.g. hepatocellular carcionoma (HCC). In some embodiments, the invention relates to the use of small-molecule compounds to inhibit, prevent and/or treat expression of the transcription factor Late SV40 Factor (LSF) for treatment of HCC or other cancer types.

  本发明涉及一般性地 [l,3]二噁英并[4,5-g]喹啉-6(5H)硫醇和[l,3]二噁英并[4,5-g][1,2,4]三唑并[1,5-a]喹啉衍生物和/或组合物的使用，用于抑制、预防和/或治疗癌症，例如肝细胞癌（HCC）。在某些实施例中，本发明涉及使用小分子化合物抑制、预防和/或治疗转录因子晚期SV40因子（LSF）的表达，用于治疗HCC或其他癌症类型。
• [1,3]DIOXOLO[4,5-G]QUINOLINE-6(5H)THIONE AND [1,3]DIOXOLO[4,5-G][1,2,4]TRIAZOLO[1,5-A]QUINOLINE DERIVATIVES AS INHIBITORS OF THE LATE SV40 FACTOR (LSF) FOR USE IN TREATING CANCER
  申请人：TRUSTEES OF BOSTON UNIVERSITY

  公开号：US20140249312A1

  公开（公告）日：2014-09-04

  The present invention relates generally to [1,3]dioxolo[4,5-g]quinoline-6(5H)thione and [1,3]dioxolo[4,5-g][1,2,4]triazolo[1,5-a]quinoline derivatives and/or compositions for use in inhibiting, preventing and/or treating cancer, e.g. hepatocellular carcionoma (HCC). In some embodiments, the invention relates to the use of small-molecule compounds to inhibit, prevent and/or treat expression of the transcription factor Late SV40 Factor (LSF) for treatment of HCC or other cancer types.

  本发明涉及[1,3]二氧杂苯并[4,5-g]喹啉-6(5H)硫醇和[1,3]二氧杂苯并[4,5-g][1,2,4]三唑[1,5-a]喹啉衍生物和/或组合物，用于抑制、预防和/或治疗癌症，例如肝细胞癌（HCC）。在某些实施例中，本发明涉及使用小分子化合物抑制、预防和/或治疗转录因子晚期SV40因子（LSF）的表达，以治疗HCC或其他癌症类型。
• [1,3] DIOXOLO [4,5-G] QUINOLINE-6(5H)THIONE DERIVATIVES AS INHIBITORS OF THE LATE SV40 FACTOR (LSF) FOR USE IN TREATING CANCER
  申请人：TRUSTEES OF BOSTON UNIVERSITY

  公开号：US20150344491A1

  公开（公告）日：2015-12-03

  The present invention relates generally to methods, compounds and/or compositions suitable for inhibiting, preventing and/or treating cancer, e.g. hepatocellular carcionoma (HCC). In some embodiments, the invention relates to the use of small-molecule compounds to inhibit, prevent and/or treat expression of the transcription factor Late SV40 Factor (LSF) for treatment of HCC or other cancer types.

  本发明涉及一般用于抑制、预防和/或治疗癌症，例如肝细胞癌（HCC）的方法、化合物和/或组合物。在某些实施例中，本发明涉及使用小分子化合物抑制、预防和/或治疗转录因子后期SV40因子（LSF）的表达，以治疗HCC或其他癌症类型。
• Hair styling composition
  申请人：KPSS-Kao Professional Salon Services GmbH

  公开号：EP2022479A1

  公开（公告）日：2009-02-11

  The present invention is related to a hair styling composition for keratin fibres especially for hair comprising at least one film forming polymer and at least one arylated silicone, preferably trimethyl pentaphenyl trisiloxane.

  本发明涉及一种用于角蛋白纤维的头发定型组合物，尤其是用于头发的组合物，其中包含至少一种成膜聚合物和至少一种芳基化硅氧烷，最好是三甲基戊苯基三硅氧烷。
• Use of pterostilbene (pter) as medicament for prevention and/or treatment of skin diseases, damages or injures or as cosmetic
  申请人：Green Molecular, S.L.

  公开号：EP2322159A1

  公开（公告）日：2011-05-18

  The present invention refers to the use of PTER, or any acceptable salt thereof, optionally in combination with QUER, or any acceptable salt thereof, for the manufacture of pharmaceutical compositions for preventing and/or treating skin diseases, damages or injuries. Those methods of prevention and/or treatment comprise the administration of an effective amount of a composition comprising PTER as active compound, or any acceptable salt thereof, optionally in combination with QUER, or any acceptable salt thereof, to the subject. PTER, or any acceptable salt thereof, optionally in combination with QUER, or any acceptable salt thereof, can be also used for manufacturing cosmetic compositions, preferably sunscreen cosmetics. The present invention also refers to the topical compositions (pharmaceuticals or cosmetics), per se, comprising PTER as active compound, or any acceptable salt thereof, optionally in combination with QUER, or any acceptable slat thereof, characterized by being formulated in the form of liposomes, and to the method for preparing said liposome formulations.

  本发明是指使用 PTER 或其任何可接受的盐，任选与 QUER 或其任何可接受的盐结合，制 造用于预防和/或治疗皮肤疾病、损伤或伤害的药物组合物。这些预防和/或治疗方法包括向受试者施用有效量的组合物，该组合物包含作为活性化合物的 PTER 或其任何可接受的盐，可选择与 QUER 或其任何可接受的盐结合使用。PTER 或其任何可接受的盐，可选择与 QUER 或其任何可接受的盐结合使用，也可用于制造化妆品组合物，最好是防晒化妆品。本发明还涉及外用组合物（药物或化妆品）本身，包括作为活性化合物的 PTER 或其任何可接受的盐，可选择与 QUER 或其任何可接受的螯合物结合使用，其特征是以脂质体的形式配制，以及制备所述脂质体制剂的方法。