9-O-acetylneuraminic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 9-O-acetylneuraminic acid
• 英文别名: (4S,5R,6R)-6-[(1R,2R)-3-acetyloxy-1,2-dihydroxypropyl]-5-amino-2,4-dihydroxyoxane-2-carboxylic acid
• 化学式: C₁₁H₁₉NO₉
• 分子量: 309.27
• InChiKey: BJOZNDRNJJZHPZ-LUWBGTNYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.4
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  180
• 氢给体数：
  6
• 氢受体数：
  10

文献信息

• MEDICINAL COMPOSITION CONTAINING SIALIC ACID DERIVATIVE
  申请人：TAIYO KAGAKU Co., LTD.

  公开号：EP0727216A1

  公开（公告）日：1996-08-21

  A medicinal composition containing a sialic acid derivative as the active ingredient and usable as an antiviral agent, diarrhea remedy, antiulcer agent, antiinflammatory agent, antiallergic agent and bifidus growth accelerator. A process for producing the derivative comprises adding almond or apricot seeds to an avian egg yolk, and can provide the target substance readily in a high yield.

  一种药物组合物，含有一种作为活性成分的序列酸衍生物，可用作抗病毒剂、止泻剂、抗溃疡剂、消炎剂、抗过敏剂和双歧杆菌生长促进剂。生产该衍生物的工艺包括在禽蛋卵黄中加入杏仁或杏籽，可以高产率提供目标物质。
• Method of using lectins for prevention and treatment of oral and alimentary tract disorders
  申请人：——

  公开号：US20030045455A1

  公开（公告）日：2003-03-06

  Infectious diseases caused by pathogenic microorganisms resident in the alimentary tract of humans and animals can be prevented and treated by administering to the alimentary tract of the human or animal an effective amount of a composition containing at least one lectin capable of binding to an infective microorganism and diminishing its infective capability of the microorganism. The lectin is administered dispersed in a pharmaceutically acceptable non-toxic vehicle. Peptic ulcer disease caused by infection with H. pylori can be treated by oral administration of lectins that bind to the pathogen. A beneficial ecology of H. pylori can be maintained in infected patients by chronic oral administration of lectins that bind to the pathogen.

  通过向人或动物的消化道中施用有效量的含有至少一种凝集素的组合物，这种凝集素能够与感染性微生物结合并降低微生物的感染能力，从而预防和治疗人和动物消化道中的病原微生物引起的传染病。凝集素分散在药学上可接受的无毒载体中。幽门螺杆菌感染引起的消化性溃疡病 幽门螺杆菌 可通过口服与病原体结合的凝集素来治疗。幽门螺杆菌的有益生态 幽门螺杆菌 通过长期口服与病原体结合的凝集素，可维持受感染病人体内幽门螺杆菌的有益生态。
• METHOD OF USING LECTINS FOR PREVENTION AND TREATMENT OF ORAL AND ALIMENTARY TRACT DISORDERS
  申请人：KRIVAN HOWARD C.

  公开号：US20100331242A1

  公开（公告）日：2010-12-30

  Infectious diseases caused by pathogenic microorganisms resident in the alimentary tract of humans and animals can be prevented and treated by administering to the alimentary tract of the human or animal an effective amount of a composition containing at least one lectin capable of binding to an infective microorganism and diminishing its infective capability of the microorganism. The lectin is administered dispensed in a pharmaceutically acceptable non-toxic vehicle. Peptic ulcer disease caused by infection with H. pylori can be treated by oral administration of lectins that bind to the pathogen. A beneficial ecology of H. pylori can be maintained in infected patients by chronic oral administration of lectins that bind to the pathogen.
• US5766887A
  申请人：——

  公开号：US5766887A

  公开（公告）日：1998-06-16
• US5834423A
  申请人：——

  公开号：US5834423A

  公开（公告）日：1998-11-10