4-[2-(5,5,8,8-Tetramethyl-6,7-dihydronaphthalen-2-yl)propyl]benzoic acid

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: 4-[2-(5,5,8,8-Tetramethyl-6,7-dihydronaphthalen-2-yl)propyl]benzoic acid
• 化学式: C₂₄H₃₀O₂
• 分子量: 350.5
• InChiKey: UVXNWPAOMNLHJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Methods of treatment with compounds having RAR alpha receptor specific or selective activity
  申请人：Allergan Sales, Inc.

  公开号：US20020077360A1

  公开（公告）日：2002-06-20

  Retinoid compounds which act specifically or selectively on RAR &agr; receptor subtypes in preference over RAR &bgr; and RAR &Ggr; receptor subtypes, posses desirable pharmaceutical properties associated with retinoids, and are particularly suitable for treatment of tumors, such as acute monocytic leukemia, cervical carcinoma, myeloma, ovarian carcinomas and head and neck carcinomas, without having one or more undesirable side effects of retinoids, such as inducement of weight loss, mucocutaneous toxicity, skin irritation and teratogenecity.

  作用于RARα亚型的视黄酸类化合物，具有优于RARβ和RARγ亚型的选择性或特异性，具有与视黄酸相关的理想药物特性，特别适用于治疗肿瘤，如急性单核细胞白血病、宫颈癌、骨髓瘤、卵巢癌和头颈癌，而不具有视黄酸的一个或多个不良副作用，如诱导体重减轻、粘膜皮肤毒性、皮肤刺激和致畸性。
• Methods of treating diseases associated with high-fat diet and vitamin A deficiency using retinoic acid receptor agonists
  申请人：Cornell University

  公开号：US10010512B2

  公开（公告）日：2018-07-03

  This invention relates to pharmaceutical composition and methods of using vitamin A and/or RARβ agonist for the treatment or prevention of diseases or conditions associated with high fat diet and/or vitamin deficiency.

  本发明涉及使用维生素 A 和/或 RARβ 激动剂治疗或预防与高脂肪饮食和/或维生素缺乏有关的疾病或病症的药物组合物和方法。
• METHODS OF TREATING DISEASES ASSOCIATED WITH HIGH-FAT DIET AND VITAMIN A DEFICIENCY USING RETINOIC ACID RECEPTOR AGONISTS
  申请人：Cornell University

  公开号：US20170135964A1

  公开（公告）日：2017-05-18

  This invention relates to pharmaceutical composition and methods of using vitamin A and/or RARβ agonist for the treatment or prevention of diseases or conditions associated with high fat diet and/or vitamin deficiency.
• US6534544B1
  申请人：——

  公开号：US6534544B1

  公开（公告）日：2003-03-18
• US6610744B2
  申请人：——

  公开号：US6610744B2

  公开（公告）日：2003-08-26