3-hydroxymethylphenyl β-D-glucopyranoside | 117685-24-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-hydroxymethylphenyl β-D-glucopyranoside
• 英文别名: (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[3-(hydroxymethyl)phenoxy]oxane-3,4,5-triol
• CAS: 117685-24-2
• 化学式: C₁₃H₁₈O₇
• 分子量: 286.282
• InChiKey: XYUHQWZOBKBXMT-UJPOAAIJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  120
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  D-葡萄糖 、 3-羟基苯甲醇 在 almond β-D-glucosidase 作用下， 以 水 、 乙腈 为溶剂， 反应 48.0h， 以5%的产率得到3-hydroxybenzyl β-D-glucopyranoside
  参考文献：
  名称：

  Enzymatic resolution of (RS)-1-phenylalkyl β-d-glucosides to (R)-1-phenylalkyl β-primeverosides and (S)-1-phenylalkyl β-d-glucosides via plant xylosyltransferase

  摘要：

  The stereoselective xylosylation of (RS)-1-phenylalkyl beta-D-glucosides was investigated using plant xylosyltransferase isolated from cultured Catharanthus roseus cells. Enzymatic xylosylation of (RS)-1-phenylethyl beta-D-glucoside afforded (R)-1-phenylethyl beta-primeveroside and (S)-1-phenylethyl beta-D-glucoside. The (R)-selective xylosylation of (RS)-1-phenylbutyl beta-D-glucoside also occurred to give (R)-1-phenylbutyl p-primeveroside and recovered (S)-1-phenylbutyl beta-D-glucoside. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.07.023

文献信息

• COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY
  申请人：BROWN Joe Ernest

  公开号：US20160008388A1

  公开（公告）日：2016-01-14

  The present invention provides novel immunotherapeutic compositions and methods useful for treating or preventing microbial infections, weakened immune systems, diseases in which cells have become obligately anerobic and cellular proliferative disorders including cancer. The immunotherapeutics herein use benzaldehyde derivatives, precursors and intermediaries alone or in combination with additional therapeutic agents to stimulate the immune system and inhibit cellular proliferation. The immunotherapeutics of the present invention are particularly useful in the treatment of microbial infections and cellular proliferative disorders which are resistant to traditional methods of treatment such as antibiotics and chemotherapy

  本发明提供了新型免疫治疗组合物和方法，可用于治疗或预防微生物感染、免疫系统衰弱、细胞成为厌氧菌和细胞增殖性疾病，包括癌症。本发明所述的免疫治疗剂使用苯甲醛衍生物、前体和中间体单独或与其他治疗剂联合使用，以刺激免疫系统并抑制细胞增殖。本发明的免疫治疗剂在治疗微生物感染和细胞增殖性疾病方面特别有用，这些疾病对传统的治疗方法如抗生素和化疗具有抵抗力。
• Compositions And Methods For Immunotherapy
  申请人：BROWN Joe Ernest

  公开号：US20090281047A1

  公开（公告）日：2009-11-12

  The present invention provides novel immunotherapeutic compositions and methods useful for treating or preventing microbial infections, weakened immune systems, diseases in which cells have become obligately anerobic and cellular proliferative disorders including cancer. The immunotherapeutics herein use benzaldehyde derivatives, precursors and intermediaries alone or in combination with additional therapeutic agents to stimulate the immune system and inhibit cellular proliferation. The immunotherapeutics of the present invention are particularly useful in the treatment of microbial infections and cellular proliferative disorders which are resistant to traditional methods of treatment such as antibiotics and chemotherapy
• Infusion Treatment Methods And Compositions Using Salicinium For Treating Cellular Proliferative Disorders And Immune Deficiencies
  申请人：Brown Joe Ernest

  公开号：US20110311477A1

  公开（公告）日：2011-12-22

  The present invention provides novel immunotherapeutic compositions and methods useful for treating or preventing microbial infections, weakened immune systems, diseases in which cells have become obligately anaerobic and cellular proliferative disorders including cancer. The immunotherapeutics herein use benzaldehyde derivatives, precursors and intermediaries alone or in combination with additional therapeutic agents to stimulate the immune system and inhibit cellular proliferation. The immunotherapeutics of the present invention are particularly useful in the treatment of microbial infections and cellular proliferative disorders which are resistant to traditional methods of treatment such as antibiotics and chemotherapy
• Methods For Treating An Immune Deficiency Or Enhancing Immune Function Using Salicinium, Non-Limited In Terms Of Treatment Indication, But Encompassing Methods For Treating Cancer And Microbial, Bacterial, Viral, Fungal; Non-Limited In Terms of Delivery Mode, Formulation
  申请人：BROWN Joe Ernest

  公开号：US20110311476A1

  公开（公告）日：2011-12-22

  The present invention provides novel immunotherapeutic compositions and methods useful for treating or preventing microbial infections, weakened immune systems, diseases in which cells have become obligately anaerobic and cellular proliferative disorders including cancer. The immunotherapeutics herein use benzaldehyde derivatives, precursors and intermediaries alone or in combination with additional therapeutic agents to stimulate the immune system and inhibit cellular proliferation. The immunotherapeutics of the present invention are particularly useful in the treatment of microbial infections and cellular proliferative disorders which are resistant to traditional methods of treatment such as antibiotics and chemotherapy
• Combinatorial Methods For Treating Cellular Proliferative Disorders And Immune Deficiencies Using Salicinium
  申请人：BROWN Joe Ernest

  公开号：US20110311478A1

  公开（公告）日：2011-12-22

  The present invention provides novel immunotherapeutic compositions and methods useful for treating or preventing microbial infections, weakened immune systems, diseases in which cells have become obligately anerobic and cellular proliferative disorders including cancer. The immunotherapeutics herein use benzaldehyde derivatives, precursors and intermediaries alone or in combination with additional therapeutic agents to stimulate the immune system and inhibit cellular proliferation. The immunotherapeutics of the present invention are particularly useful in the treatment of microbial infections and cellular proliferative disorders which are resistant to traditional methods of treatment such as antibiotics and chemotherapy