1-(4-chlorobenzoyl)-6-nitro-1,2-dihydroquinoline-2-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(4-chlorobenzoyl)-6-nitro-1,2-dihydroquinoline-2-carbonitrile
• 英文别名: 1-(4-chlorobenzoyl)-6-nitro-2H-quinoline-2-carbonitrile
• 化学式: C₁₇H₁₀ClN₃O₃
• 分子量: 339.738
• InChiKey: YIDSPCFILARTAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  89.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] Substituted urea-octatydroindols as antagonists of melanin concentrating hormone receptor 1 (MCH1R)<br/>[FR] UREE-OCTAHYDROINDOLES SUBSTITUES UTILISES EN TANT QU'ANTAGONISTES DU RECEPTEUR 1 DE L'HORMONE CONCENTRANT LA MELANINE (MCH1R)
  申请人：BIOVITRUM AB

  公开号：WO2005051381A1

  公开（公告）日：2005-06-09

  The invention relates to compounds of the general formula (I) wherein R0, R1, R2, R3, R4, R5, R6, R7, R8, R9, Ar, and X are as defined in the description, or a pharmaceutically acceptable salt, hydrates, geometrical isomers, racemates, tautomers, optical isomers, N-oxides and prodrug forms thereof. The compounds may be used for the treatment or prophylaxis of disorders related to the MCH1R receptor and for modulation of appetite. The invention also relates to such use as well as to pharmaceutical formulations comprising a compound of formula (I).

  该发明涉及通式（I）的化合物，其中R0、R1、R2、R3、R4、R5、R6、R7、R8、R9、Ar和X如描述中所定义，或其药学上可接受的盐、水合物、几何异构体、消旋体、互变异构体、光学异构体、N-氧化物及其前药形式。这些化合物可用于治疗或预防与MCH1R受体相关的疾病，并用于调节食欲。该发明还涉及该用途以及包含通式（I）化合物的药物配方。
• 1, 2-Dihydroquinoline derivatives and method for using the same to treat HIV infections
  申请人：Olson Matthew

  公开号：US20050203129A1

  公开（公告）日：2005-09-15

  The present invention is directed to compound of formula (A): wherein R 1 is selected from (a) alkyl, alkenyl, alkynyl, cycloalkyl, aryl, and heteroaryl, or (b) CN and —C(NR 10 R 11 )═N—R 12 , R 2 is selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, aryl and heteroaryl, R 3 -R 12 are as described within the specification, and A is O, NR 9 or S, or a prodrug, a pharmaceutically acceptable salt or a pharmaceutically active metabolite thereof, provided that R 1 is not alkyl when R 2 is pyridine, provided that at least one of R 3 -R 8 is not H or F when A is O, R 1 is (b) and R 2 is a phenyl ring, a phenyl ring substituted at the para position with halo, —CN, —OCH 3 , —CF 3 or —CO 2 CH 3 , a quinoline or an ethylene substituted with a phenyl ring or a 3,4-methylenedioxyphenyl moiety, provided that R 4 is not methyl when R 3 and R 5 -R 8 are H, A is O, R 1 is (b) and R 2 is 4-chlorophenyl, and provided that R 6 is not Cl when R 3 -R 5 and R 7 -R 8 are H, R 1 is CN and R 2 is phenyl. This invention is also directed to methods of using the same for treating HIV infections, or AIDS, or preventing replication.

  本发明涉及以下化合物（A）的公式： 其中R1从（a）烷基、烯基、炔基、环烷基、芳基和杂环芳基中选择，或者从（b）CN和—C（NR10R11）═N—R12中选择，R2从烷基、烯基、炔基、环烷基、芳基和杂环芳基中选择，R3-R12如规范中所述，A为O、NR9或S，或其前药、药学上可接受的盐或药学活性代谢物，条件是当R2为吡啶时，R1不是烷基，当A为O时，R1为（b）且R2为苯环时，R3-R8中至少有一个不是H或F，R1为（b）且R2为苯环时，R4不是甲基，R3和R5-R8为H，A为O时，R1为（b）且R2为4-氯苯基时，R6不是Cl，R3-R5和R7-R8为H，R1为CN且R2为苯环。本发明还涉及使用该化合物用于治疗HIV感染或艾滋病，或预防复制的方法。
• US7553967B2
  申请人：——

  公开号：US7553967B2

  公开（公告）日：2009-06-30
• [EN] 1,2-DIHYDROQUINOLINE DERIVATIVES AND METHOD FOR USING THE SAME TO TREAT HIV INFECTION<br/>[FR] DERIVES DE LA 1,2-DIHYDROQUINOLINE ET LEUR METHODE D'UTILISATION POUR TRAITER LES INFECTIONS PAR LE VIH
  申请人：WYETH CORP

  公开号：WO2005090309A1

  公开（公告）日：2005-09-29

  The present invention is directed to compound of formula (A): wherein R1 is selected from (a) alkyl, alkenyl, alkynyl, cycloalkyl, aryl, and heteroaryl, or (b) CN and -C(NR10R11)=N-R12 is selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, aryl and heteroaryl, R3-R12 are as described within the specification, and A is O, NR9 or S, or a prodrug, a pharmaceutically acceptable salt or a pharmaceutically active metabolite thereof, provided that R1 is not alkyl when R2 is pyridine, provided that at least one of R3-R8 is not H or F when A is O, R1 is (b) and R2 is a phenyl ring, a phenyl ring substituted at the para position with halo, -CN, -OCH3 or -CO2CH3, a quinoline or an ethylene substituted with a phenyl ring or a 3,4-methylenedioxyphenyl moiety, provided that R4 is not methyl when R3 and R5-R8 are H, A is O, R1 is (b) and R2 is 4-chlorophenyl, and provided that R6 is not C1 when R3-R5 and R7-R8 are H, R1 is CN and R2 is phenyl. This invention is also directed to methods of using the same for treating HIV infections or AIDS, or preventing replication.