1-cyclopropyl-6-fluoro-1,4-dihydro-7-(2-methyl-2,8-diazabicyclo[4.3.0]non-8-yl)-4-oxo-3-quinolinecarboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-cyclopropyl-6-fluoro-1,4-dihydro-7-(2-methyl-2,8-diazabicyclo[4.3.0]non-8-yl)-4-oxo-3-quinolinecarboxylic acid
• 英文别名: 1-cyclopropyl-6-fluoro-7-(1-methyl-3,4,4a,5,7,7a-hexahydro-2H-pyrrolo[3,4-b]pyridin-6-yl)-4-oxoquinoline-3-carboxylic acid
• 化学式: C₂₁H₂₄FN₃O₃
• 分子量: 385.438
• InChiKey: QKYHBFXUZAFUEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  64.1
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• FLUOROQUINOLONE DERIVATIVES FOR OPHTHALMIC APPLICATIONS
  申请人：Owen Geoffrey Robert

  公开号：US20090209574A1

  公开（公告）日：2009-08-20

  The present invention relates to fluoroquinolone derivatives having enhanced ocular penetration characteristics and/or antimicrobial activity, and to compositions comprising such derivatives. The derivatives and compositions are particularly well suited for treating ophthalmic bacterial infections. The present invention more particularly relates to the discovery that a 2-methyl substitution on a diazabicyclo group attached to a fluoroquinolone ring system produces improved permeability characteristics, and that a 5-amino substitution on a fluoroquinolone ring system results in improved anti-microbial activity.

  本发明涉及具有增强眼部渗透特性和/或抗微生物活性的氟喹诺酮衍生物，以及包含这些衍生物的组合物。这些衍生物和组合物特别适用于治疗眼部细菌感染。本发明更具体地涉及发现，在连接到氟喹诺酮环系统上的二氮杂双环基团上进行2-甲基取代会产生改善的渗透特性，并且在氟喹诺酮环系统上进行5-氨基取代会导致改善的抗微生物活性。
• [EN] FLUOROQUINOLONE DERIVATIVES FOR OPHTHALMIC APPLICATIONS<br/>[FR] DÉRIVÉS DE FLUOROQUINOLONE POUR APPLICATIONS OPHTALMIQUES
  申请人：ALCON RES LTD

  公开号：WO2009103053A1

  公开（公告）日：2009-08-20

  The present invention relates to fluoroquinolone derivatives having enhanced ocular penetration characteristics and/or antimicrobial activity, and to compositions comprising such derivatives. The derivatives and compositions are particularly well suited for treating ophthalmic bacterial infections. The present invention more particularly relates to the discovery that a 2-methyl substitution on a diazabicyclo group attached to a fluoroquinolone ring system produces improved permeability characteristics, and that a 5-amino substitution on a fluoroquinolone ring system results in improved anti-microbial activity.