N-(4-Chlorobenzyl)-2-{[(2,3-dihydroxypropyl)sulfanyl]methyl}-9-(morpholin-4-ylmethyl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(4-Chlorobenzyl)-2-{[(2,3-dihydroxypropyl)sulfanyl]methyl}-9-(morpholin-4-ylmethyl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamide
• 英文别名: N-(4-Chlorobenzyl)-2-{[(2,3-dihydroxypropyl)sulfanyl]methyl]-9-(4-morpholinylmethyl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino-2,3,4-ij]quinoline-6-carboxamide；N-[(4-chlorophenyl)methyl]-3-(2,3-dihydroxypropylsulfanylmethyl)-7-(morpholin-4-ylmethyl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5,7,9(13),11-tetraene-11-carboxamide
• 化学式: C₂₈H₃₂ClN₃O₆S
• 分子量: 574.098
• InChiKey: OWIMMPWRWNSINN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  39
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  137
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Oxazinoquinolones useful for the treatment of viral infections
  申请人：——

  公开号：US20020103170A1

  公开（公告）日：2002-08-01

  The present invention provides a compound of formula I 1 which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.

  本发明提供了一种化合物I1的公式，该化合物可用作抗病毒剂，特别是用作抗疱疹病毒家族的药剂。
• Method of preventing or treating atherosclerosis or restenosis
  申请人：——

  公开号：US20040186131A1

  公开（公告）日：2004-09-23

  The present invention provides a method of preventing or treating atherosclerosis or restenosis in mammals, which comprises administering an effective amount of a compound selected from the group consisting of structures of Formulas I to XV: 1 wherein the various groups in the Formulae are defined herein.

  本发明提供了一种预防或治疗哺乳动物动脉粥样硬化或再狭窄的方法，该方法包括施用有效量的选自由式I至XV的结构组成的组的化合物： 1 其中式中各基团的定义见本文。
• OXAZINOQUINOLONES USEFUL FOR THE TREATMENT OF VIRAL INFECTIONS
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1299395B1

  公开（公告）日：2004-09-15
• US6673793B2
  申请人：——

  公开号：US6673793B2

  公开（公告）日：2004-01-06
• [EN] OXAZINOQUINOLONES USEFUL FOR THE TREATMENT OF VIRAL INFECTIONS<br/>[FR] OXAZINOQUINOLONES UTILES DANS LE TRAITEMENT DES INFECTIONS VIRALES
  申请人：UPJOHN CO

  公开号：WO2002004462A1

  公开（公告）日：2002-01-17

  The present invention provides a compounds of formula (I) which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.